Studies brain connections and function in schizophrenia using brain scans
Collects brain scans and data from adults with schizophrenia or schizoaffective disorder and others.
Key facts
- Who runs it
- University of Texas Southwestern Medical Center
- Where
- Dallas, United StatesSee the site
- Trial code
- Registry title
- Database Registry for Neural Network Biomarkers in Psychosis
- Status
- Recruiting
- People taking part
- 1,000 people, planned
- Started
- Mar 2010
- Expected to end
- Apr 2029
- Type of study
- Observational, 2 groups
- Record updated
- 23 April 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with schizophrenia or schizoaffective disorder, and also healthy volunteers without severe mental illness. It collects brain scans, blood and interview data for a registry.
- Age
- 18 to 60 years
- Sex
- All sexes
- Disease stage
- People with a DSM-IV-TR diagnosis of schizophrenia or schizoaffective disorder; or healthy volunteers with no past or current severe mental illness.
Main reasons for not taking part
- Organic brain disease
- Alcohol or substance abuse within the last month, or dependence within the last three months
- Serious, unstable medical illness
- History of serious head injury
- Pregnant women
The registry criteria, word for word
Show all 22 criteriaShow less
Who can take part
- Volunteers with Schizophrenia or other mental illness
- Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnosis of Schizophrenia or Schizoaffective disorder
- Competent to give informed consent
- All races and ethnicities
- Eyesight corrected to 20-40 or better
- Able to read, speak, and understand English; Healthy volunteers
- No past or current severe mental illness
- All races and ethnicities
- Eyesight corrected to 20-40 or better
- Able to read, speak, and understand English
Who cannot take part
- Current use of psychoactive drugs excluding nicotine and caffeine
- Volunteers with schizophrenia or other mental illness
- Diagnosis of an organic brain disease
- Serious, unstable medical illness
- History of serious head injury
- History of psychiatric illness
- Diagnosis of an organic brain disease
- Serious, unstable medical illness
- History of serious head injury
- Diagnosis of DSM-IV-TR alcohol or substance abuse within the last month or DSM-IV-TR alcohol or substance dependence within the last three months
- Pregnant women; Healthy volunteers
- Pregnant women
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Where in United States
- University of Texas Southwestern Medical CenterDallas, United StatesContact: Elena Ivleva, M.D., Ph.D.Taking people
About the trial
What the trial wants to find out
Several observations have been made with magnetic resonance imaging (MRI) that characterize brain connections and brain function in individuals with schizophrenia and other mental disorders. For example, research investigating schizophrenia focuses on the dysfunction of connections within and between the medial temporal lobe and the prefrontal cortex as well as other pertinent brain regions. This database registry will allow for the collection of clinical interview data, behavioral data, blood, magnetic resonance imaging (MRI) data, and functional magnetic resonance imaging (fMRI) data on individuals with and without mental disorders to better understand how connections in the brain and various brain regions function differently while volunteers perform various cognitive tasks. This is an observational study that is being conducted to collect data and place it in a registry for current and future investigational questions related to imaging in mental disorders.
The 2 groups in the trial
- Patient volunteers
This group is comprised of persons with Schizophrenia and Schizoaffective.
- Healthy volunteers
This group is comprised of individuals who have no current or past psychiatric diagnosis.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Database Registry to Examine Brain Connections and Brain Function in Mental Disorders and Neural Network Biomarkers for Relational Memory and Psychosis in Schizophrenia
- Plain-language title
- Studies brain connections and function in schizophrenia using brain scansGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT01409109, who can take part
- Record updated
- 23 April 2026