Schizophrenia trials in United States

In United States 177 Also abroad 470

177 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium (CNTRACS): Study 1
Where
Baltimore, Chicago, Irvine, Minneapolis, St Louis
Age
18 years to 59 years
People
325
Run by
Washington University School of Medicine
See details and how to joinNCT07853807
No phaseNot yet taking people in United States
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2
Where
Baltimore, Chicago, Irvine, Minneapolis, St Louis
Age
18 years to 59 years
People
325
Run by
Washington University School of Medicine
See details and how to joinNCT07875790
No phaseTaking people
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3
Where
Minneapolis, St Louis
Age
18 years to 59 years
People
10,000
Run by
Washington University School of Medicine
See details and how to joinNCT07900893
Phase 1Taking people
A Study to Assess the Safety, Tolerability and Pharmacokinetics of XEP527 in Patients With Stable Schizophrenia
Where
Bentonville
Age
18 years to 65 years
People
36
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07908680
Phase 3Taking people
A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents
Where
Anaheim, Atlanta, Bloomfield Hills, Boca Raton, Boston, Chicago, Chino, Cincinnati, Columbia, Culver City, Dallas, Danville, Decatur, Dothan, Everett, Gainesville, Garland, Glendale, Great Neck, Hollywood, Houston, Las Vegas, Lawrenceville, Lexington, Lincoln, Los Angeles, Louisville, Nashville, Neptune City, New Haven, Orange, Orangeburg, Orem, Orlando, Phoenix, Pittsburgh, Plano, Richmond, Saint Charles, San Antonio, San Diego, San Francisco, San Rafael, Spring, Staten Island, Stone Mountain, The Bronx, Virginia Gardens, West Chester, West Point, Worcester
Age
5 years to 17 years
People
400 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT07424404 · EU 2025-524062-16-00
No phaseNot yet taking people in United States
Deep Brain Stimulation for Treatment-Resistant Schizophrenia
Where
Baltimore
Age
22 years to 65 years
People
15
Run by
Johns Hopkins University
See details and how to joinNCT07592611
No phaseTaking people
MI-CBTech: A Mobile Intervention for Community Integration in Homeless-Experienced Veterans With SMI
Where
West Los Angeles
Age
18 years to 65 years
People
50
Run by
VA Office of Research and Development
See details and how to joinNCT06138054
No phaseTaking people
Tau Biomarkers in Late-onset Psychosis (LOP)
Where
Manhasset
Age
65 years to 85 years
People
16
Run by
Jeremy Koppel
See details and how to joinNCT06336382
No phaseTaking people
REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)
Where
Cleveland
Age
18 years to 50 years
People
30
Run by
Case Western Reserve University
See details and how to joinNCT07006935
Phase 3Taking people
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
Where
Anaheim, Atlanta, Avon Lake, Bellevue, Bloomfield Hills, Cincinnati, Colorado Springs, Coppell, Everett, Fort Myers, Fort Worth, Gainesville, Garden Grove, Garfield Heights, Hialeah, Homestead, Houston, Indianapolis, Jacksonville, Las Vegas, Lawrenceville, Lincoln, Little Rock, Miami, Miami Gardens, Miami Lakes, Naperville, Nashville, New York, Norman, Oceanside, Oklahoma City, Orlando, Phoenix, Plano, Pompano Beach, Redlands, Richmond, Sacramento, Saint Charles, San Diego, Savannah, Staten Island, St. Petersburg, West Covina, West Palm Beach
Age
5 years to 17 years
People
300 worldwide
Run by
Intra-Cellular Therapies, Inc.
See details and how to joinNCT06229210 · EU 2023-507068-38-00
Phase 2Taking people
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease
Where
Anaheim, Bellevue, Bonita Springs, Brandon, Charlotte, Coral Springs, Cypress, Delray Beach, Doral, Homestead, Los Alamitos, Maitland, Matthews, Miami, Newport Beach, Orange, Orlando, San Antonio, Sarasota, Savannah, Tampa, Toms River, Walnut Creek
Age
55 years and over
People
370 worldwide
Run by
Intra-Cellular Therapies, Inc.
See details and how to joinNCT06540833
Phase 1Taking people
A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With Schizophrenia
Where
Atlanta, Austin, Cedarhurst, Chicago, Garden Grove, Kalamazoo, Richardson, Staten Island
Age
18 years to 60 years
People
64
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07615426
No phaseNot yet taking people in United States
NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia
Where
Minneapolis
Age
18 years to 79 years
People
168
Run by
University of Minnesota
See details and how to joinNCT07788755
No phaseTaking people
Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)
Where
Anaheim, Apple Valley, Atlanta, Austell, Austin, Bloomfield Township, Bonita Springs, Bryant, Buffalo, Cary, Charlotte, Chino, Cordova, Crystal Lake, Dallas, Detroit, Duluth, Fort Worth, Franklin, Hagerstown, Hartford, Hialeah, Homestead, Houston, Irving, Kendall, La Palma, Las Vegas, Lincoln, Marietta, Mason, McKinney, Miami, Mission Viejo, Monsey, Nashville, Oceanside, Oklahoma City, Orange City, Orlando, Orland Park, Petersburg, Philadelphia, Redlands, Richmond, Rochester, San Antonio, San Diego, Seal Beach, Stafford, Stanford, State College, Tulsa, Warrenville, White Plains, Wilmington, Worcester, Wyomissing
Age
18 years and over
People
1,500
Run by
Bristol-Myers Squibb
See details and how to joinNCT07379827
Phase 2Taking people
Study to Evaluate the Safety and Efficacy of Ublituximab in Participants With Schizophrenia
Where
Little Rock, Richardson
Age
18 years to 60 years
People
60
Run by
TG Therapeutics, Inc.
See details and how to joinNCT07680946
Phase 3Taking people
Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia
Where
Anaheim, Atlanta, Austin, Bellflower, Bentonville, Boynton Beach, Chicago, Cincinnati, Culver City, Gaithersburg, Garden Grove, Hollywood, La Habra, Lemon Grove, Little Rock, Miami, Miami Lakes, Miami Springs, Montclair, Oakland Park, Oklahoma City, Orange, Pico Rivera, Redlands, Richardson, Riverside, Rogers, Sandy Springs, Savannah, Torrance
Age
18 years to 65 years
People
472 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT07686263 · EU 2025-523664-20-00
No phaseTaking people
Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention
Where
Houston
Age
9 years to 26 years
People
100
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT07743645
No phaseNot yet taking people in United States
Reducing Stigma - A Treatment for Early Psychosis to Prevent Suicide
Where
Providence
Age
15 years to 25 years
People
35
Run by
Butler Hospital
See details and how to joinNCT07898631
No phaseTaking people
Impact of Cerebellar TMS on Brain and Cognitive Functions in Schizophrenia: a Pilot Study
Where
New York
Age
18 years to 60 years
People
40
Run by
Northwell Health
See details and how to joinNCT05389787
Phase 3Taking people
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
Where
Anaheim, Atlanta, Atlantis, Austin, Bellevue, Belmont, Bloomfield Township, Bonita Springs, Boston, Chandler, Chino, Cleveland, Columbia, Columbus, Cutler Bay, Dallas, Dayton, Daytona Beach, Deerfield Beach, DeSoto, Doral, El Paso, Farmington, Flowood, Fort Worth, Gilbert, Greensboro, Gulf Breeze, Hialeah, Homestead, Houston, Independence, Irving, Kirkland, Lady Lake, Long Beach, Los Angeles, Matthews, Miami, Miami Gardens, Miami Lakes, Morehead City, Naples, Nashville, New Windsor, North Dartmouth, Ocoee, Oklahoma City, Orange, Orlando, Ormond Beach, Pasadena, Phoenix, Plano, Port Orange, Providence, Rancho Cucamonga, Salem, San Antonio, Scottsdale, Shelby, South Dartmouth, Springfield, Stafford, St Louis, Sweetwater, Syracuse, Tampa, The Villages, Toms River, Vienna, Wellington, West Palm Beach, Woodmere
Age
55 years to 90 years
People
406 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT06585787 · EU 2024-516363-92-00
No phaseNot yet taking people in United States
Non-Invasive Vagus Nerve Stimulation as a Probe to Map Functional Connectivity in Schizophrenia Using Functional Magnetic Resonance Imaging
Where
Birmingham
Age
19 years to 55 years
People
40
Run by
University of Alabama at Birmingham
See details and how to joinNCT07897266
No phaseEnrolling by invitation
Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization
Where
McKeesport, Pittsburgh
Age
18 years to 65 years
People
1,000
Run by
Stanford University
See details and how to joinNCT07130500
No phaseTaking people
Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis
Where
Los Angeles, San Diego
Age
12 years to 30 years
People
108
Run by
University of California, San Diego
See details and how to joinNCT07756567
No phaseTaking people
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
Where
Charlestown
Age
18 years to 45 years
People
60
Run by
Massachusetts General Hospital
See details and how to joinNCT06386588
Phase 4Taking people
A Study to Evaluate the Effect of KarXT on Urological Safety
Where
Austin, Bellflower, Boynton Beach, Chicago, Chino, DeSoto, Garden Grove, Las Vegas, Lauderhill, Little Rock, Marlton, Orange, Philadelphia, Torrance, West Covina
Age
18 years to 65 years
People
60
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221877