Genetic study of insulin and gut hormones in people with cystic fibrosis
Studies genes and gut hormones linked to diabetes in people with cystic fibrosis.
Plain-language title generated from the registry record
Registry title: Genetics of Insulin and Incretins in Cystic Fibrosis
Key facts
- Where
- Philadelphia, United StatesSee the 2 sites
Where in United States
- The Children's Hopsital of PhiladelphiaPhiladelphia, United StatesTaking people
- The University of PennsylvaniaPhiladelphia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Children's Hospital of Philadelphia
- Trial code
- NCT01852448
- Record updated
- 16 September 2026
- Original description
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes.Read full original descriptionShow less
Evaluation of the Enteroinsular Axis in Cystic Fibrosis
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes.
The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load).
This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.
Inclusion: Subjects age >2y; Diagnosis of Cystic Fibrosis; For subjects< 18 years, parental/guardian permission (informed consent) and if appropriate, child assent.