Testing whether gut hormones explain benefits of gastric bypass surgery
Tests gut hormones in adults with obesity and diabetes after gastric bypass.
Plain-language title generated from the registry record
Registry title: Gut Hormones and Roux en Y Gastric Bypass
Key facts
- Where
- London, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT01945840, who can take part
Where in United Kingdom
- NIHR/Wellcome Trust Imperial CRF, Hammersmith HospitalLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Imperial College London
- Trial code
- NCT01945840
- Record updated
- 20 April 2021
- Original description
The purpose of this study is to assess whether the changes in gut hormones seen following Roux en Y Gastric Bypass surgery are responsible for some of the beneficial effects seen post-operatively.Read full original descriptionShow less
Do Gut Hormones Mediate the Beneficial Effects of Roux-en-Y Bypass?
The purpose of this study is to assess whether the changes in gut hormones seen following Roux en Y Gastric Bypass surgery are responsible for some of the beneficial effects seen post-operatively.
Inclusion: Aged 18 - 70 years; Male or female; Eligible for bariatric surgery under the NHS; Diagnosed with impaired glucose regulation or type 2 diabetes, according to WHO 2011 criteria; Those with diabetes should be stable and well controlled with either diet or one oral hypoglycaemic agent; HbA1c ≤9.0% or 74.9 mmol/mol.
Exclusion: Volunteers on anti-coagulants such as warfarin and factor Xa inhibitors will not undergo adipose tissue biopsy; Previous bariatric surgery; Unable to undergo fMRI due to:; Claustrophobia; Pacemaker, metal implant, clips, implanted device, shrapnel or bullet, metal in eyes that precludes magnetic resonance imaging; Significant structural abnormality on magnetic resonance brain scan; History of any medical, psychological or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study or potentially cause harm to the volunteer; History of hypersensitivity to any of the components of the subcutaneous infusions; Uncontrolled hypertension; Any other co-morbidity that would compromise the validity of the study or the safety of the participant such as heart failure, clinically apparent cardiovascular disease; Without access at home to a telephone or other factor likely to interfere with ability to participate reliably in the study; Pregnancy or breastfeeding; Smokers; Unable to maintain adequate contraception for the duration of the study and for one month afterwards; Donated blood during the preceding 3 months or intention to do so before the end of the study; Insulin treatment; Unable to give informed consent.