Obesity trials in United Kingdom

In United Kingdom 84 Also abroad 1939

84 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Probiotics, Cognition and Metabolic Health in Young Adults With Overweight or Obesity
Where
Leeds
Age
18 years to 40 years
People
70
Run by
Leeds Beckett University
See details and how to joinNCT07073781
Phase 3Taking people
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
Where
Airdrie, Birmingham, Chippenham, Glasgow, Leicester, London, Newcastle upon Tyne, Soham, Swansea
Age
18 years and over
People
2,000 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07351045 · EU 2025-523104-71-00
Phase 3Taking people
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
Where
Aberdeen, Antrim, Blackpool, Bristol, Dundee, Hounslow, Hull, Nuneaton, Plymouth, Taunton
Age
18 years and over
People
1,600 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07351058 · EU 2025-523106-32-00
Phase 1Taking people
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
Where
Harrow
Age
18 years to 65 years
People
104 worldwide
Run by
AstraZeneca
See details and how to joinNCT07511205
Phase 3Taking people
A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus
Where
Airdrie, Chippenham, Hull, Llandough, Rotherham
Age
18 years and over
People
500 worldwide
Run by
AstraZeneca
See details and how to joinNCT07776509 · EU 2025-523295-23-00
Phase 3Not yet taking people in United Kingdom
A Research Study to Investigate How Well the Medicine CagriSema Lowers High Blood Pressure in People Living With High Blood Pressure and Obesity
Where
Bristol, Bushey, Cambridge, Chippenham, Harrow, Hounslow, London, Newquay, Wisbech
Age
18 years and over
People
1,408 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07919405
Phase 3Taking people
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
Where
Barnsley, Bristol, Cambridge, Dundee, Harrow, Hull, Liverpool
Age
6 years to 17 years
People
125 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06672549
Phase 3Taking people
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Where
Barnsley, Dundee, Hull
Age
12 years to 17 years
People
150 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06672939 · EU 2024-514081-40-00
Phase 2Taking people
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
Where
Birmingham, Blackpool, Bristol, Bromborough, Newcastle, Newquay, Nuneaton, Poole, Rotherham, Torpoint
Age
18 years to 75 years
People
200 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06897475 · EU 2024-520328-27-00
Phase 3Taking people
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
Where
Bristol, Dundee, Exeter, London
Age
18 years to 70 years
People
350 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06937086 · EU 2024-520209-38-00
No phaseTaking people
Safety and Effectiveness of Orbera365™ Intragastric Balloon System
Where
Coventry
Age
18 years and over
People
200 worldwide
Run by
Boston Scientific Corporation
See details and how to joinNCT07062094
Phase 3Taking people
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Where
Bristol, Glasgow, London, Newcastle, Penzance, Rotherham, Sheffield, York
Age
18 years and over
People
900 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07353931 · EU 2025-523768-19-00
Phase 3Not yet taking people in United Kingdom
A Study of EloraTZP in Adult Participants With Obesity Without Type 2 Diabetes
Where
Blackpool, Lancashire, London, Penzance, Romsey, West Kirby
Age
18 years and over
People
2,115 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07881432 · EU 2026-526047-34-00
Phase 1Not yet taking people in United Kingdom
A Trial to Assess the Relative Bioavailability of Different Subcutaneous Formulations of AZD9550 and AZD6234
Where
Ruddington
Age
18 years to 55 years
People
60
Run by
AstraZeneca
See details and how to joinNCT07911514
Phase 3Not yet taking people in United Kingdom
SYNCHRONIZE®-HERA: A Study to Test Whether Survodutide Helps Women Who Are Living With Overweight or Obesity and Are Going Through or Have Finished Menopause, to Lose Weight
Where
Glasgow, Leicester
Age
45 years to 65 years
People
600 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07850050 · EU 2026-527092-29-00
Phase 3Not yet taking people in United Kingdom
ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
Where
Bradford, Leeds, Leicester, London, Plymouth
Age
18 years and over
People
600 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07850063 · EU 2026-527091-88-00
Phase 3Taking people
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Where
Airdrie, Ashington, Belfast, Bournemouth, Bridgend, Bristol, Chichester, Dundee, Exeter, Glasgow, Great Cambourne, High Wycombe, Inverness, Kilmarnock, Leicester, London, Manchester, Newcastle upon Tyne, Portadown, Craigavon, Sandbach, Stockton-on-Tees, Thetford, Wakefield, West Kirby
Age
18 years to 99 years
People
5,056 worldwide
Run by
Amgen
See details and how to joinNCT07037459
Phase 3Taking people
A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight
Where
Chippenham, Corby, Dunfermline, Hull, Northwood
Age
18 years and over
People
1,500 worldwide
Run by
AstraZeneca
See details and how to joinNCT07784270
Phase 1/2Taking people
A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity
Where
Harrow, Merthyr Tydfil
Age
18 years to 75 years
People
400 worldwide
Run by
Wave Life Sciences USA, Inc.
See details and how to joinNCT06842186 · EU 2024-520203-41-00
No phaseEnrolling by invitation
Real-world Exploration of Digital iNnovation in the Management of Excess Weight
Where
London
Age
18 years and over
People
580
Run by
Guy's and St Thomas' NHS Foundation Trust
See details and how to joinNCT07283978
No phaseTaking people
A Study on Ubiquinol on Fatigue and Muscle Strength in Healthy Adults Taking GLP-1 Agonists
Where
Glasgow
Age
30 years to 65 years
People
90
Run by
StudySetGo
See details and how to joinNCT07789106
Phase 3Taking people
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
Where
Ashton-under-Lyne, Blackpool, Chesterfield, Corby, Ely, Glasgow, Hounslow, Leicester, Metropolitan Borough of Wirral, Nantwich, Poole, Rotherham, Stowmarket, Wansford, Witney, Yate
Age
18 years and over
People
4,500 worldwide
Run by
AstraZeneca
See details and how to joinNCT07667803
Phase 3Not yet taking people in United Kingdom
A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
Where
Aberdeen, Ashton-under-Lyne, Bradford on Avon, Brighton, Bristol, Chichester, Coventry, Dundee, Glasgow, Harrow, Leicester, Liverpool, London, Newcastle upon Tyne, Newquay, Penicuik, Poole, Soham, Southampton, Thetford, West Bromwich, West Kirby
Age
45 years to 64 years
People
8,500 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07861100 · EU 2026-525182-53-00
Phase 3Taking people
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
Where
Birmingham
Age
18 years to 99 years
People
950 worldwide
Run by
Amgen
See details and how to joinNCT07684144 · EU 2025-524788-19-00
Phase 3Taking people
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
Where
Birmingham, Liverpool, London
Age
8 years to 18 years
People
460 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07253285 · EU 2023-509176-42-00