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Taking people in NetherlandsNo phase

Following colorectal cancer patients to collect data over time

Observes people with colorectal cancer to learn what affects their outcomes.

Plain-language title generated from the registry record
Registry title: Prospective Data Collection Initiative on Colorectal Cancer

Key facts

Where
's-Hertogenbosch, Alkmaar, Almere Stad, Amersfoort, Amstelveen, Amsterdam, Apeldoorn, Arnhem, Assen, Beugen, Beverwijk, Breda, Capelle aan den IJssel, Delft, Deventer, Dirksland, Doetinchem, Dordrecht, Drachten, Ede, Eindhoven, Enschede, Geldrop, Goes, Gorinchem, Gouda, Groningen, Haarlem, Hardenberg, Harderwijk, Heerenveen, Helmond, Hengelo, Hilversum, Hoogeveen, Hoorn, Leeuwarden, Leiden, Maastricht, Nieuwegein, Nijmegen, Oss, Roermond, Roosendaal, Rotterdam, Sittard, Sneek, Terneuzen, The Hague, Tiel, Tilburg, Utrecht, Venlo, Weert, Winterswijk, Zaandam, and Zwolle, NetherlandsSee the 70 sites

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with colorectal, small bowel or anal cancer. Doctors will collect health data on them over time.

Age
18 years or older
Sex
Women and men can join
Disease stage
Colorectal, small bowel or anal cancer proven by tissue testing, or strongly suspected after imaging

Main reasons for not taking part

  • Patients who are mentally incompetent

Read by machine on 12 November 2026.

Where in Netherlands

  • Jeroen Bosch Ziekenhuis's-Hertogenbosch, NetherlandsContact: M.L. WumkesTaking people
  • Noordwest ZiekenhuisgroepAlkmaar, NetherlandsContact: M.P. HendriksTaking people
  • FlevoziekenhuisAlmere Stad, NetherlandsContact: D. SommeijerTaking people
  • Meander Medisch CentrumAmersfoort, NetherlandsContact: J.M. van DodewaardTaking people
  • Ziekenhuis AmstellandAmstelveen, NetherlandsContact: T. KuiperTaking people
  • Antoni van LeeuwenhoekAmsterdam, NetherlandsContact: N.F.M. KokTaking people
  • OLVGAmsterdam, NetherlandsContact: A.U.G van LentTaking people
  • VUmcAmsterdam, NetherlandsContact: M.R. MeijerinkTaking people
  • Gelre ZiekenhuizenApeldoorn, NetherlandsContact: P. van DuijvendijkTaking people
  • RijnstateArnhem, NetherlandsContact: T. van VoorthuizenTaking people
  • Wilhelmina Ziekenhuis AssenAssen, NetherlandsContact: P. NieboerTaking people
  • Maasziekenhuis PanteinBeugen, NetherlandsContact: M. BlusséTaking people
  • Rode Kruis ZiekenhuisBeverwijk, NetherlandsContact: A. GoosensTaking people
  • Amphia ZiekenhuisBreda, NetherlandsContact: J. SchreinemakersTaking people
  • IJsselland ZiekenhuisCapelle aan den IJssel, NetherlandsContact: M. VermaasTaking people
  • Reinier de GraafDelft, NetherlandsContact: J.W.T. DekkerTaking people
  • Deventer ZiekenhuizenDeventer, NetherlandsContact: K. TalsmaTaking people
  • Van Weel-Bethesda ZiekenhuisDirksland, NetherlandsContact: A. DietvorstTaking people
  • Slingeland ZiekenhuisDoetinchem, NetherlandsContact: R.A.W. van de WeteringTaking people
  • Albert Schweitzer ZiekenhuisDordrecht, NetherlandsContact: E.J.Th. BeltTaking people
  • Ziekenhuis Nij SmellingheDrachten, NetherlandsContact: Miriam Koopman, MD, PhDTaking people
  • Ziekenhuis Gelderse ValleiEde, NetherlandsContact: A.W. HaringhuizenTaking people
  • Catharina ZiekenhuisEindhoven, NetherlandsContact: I.H.J.T. de HinghTaking people
  • Máxima Medisch CentrumEindhoven, NetherlandsContact: L. SimkensTaking people
  • Medisch Spectrum TwenteEnschede, NetherlandsContact: L. MekenkampTaking people
  • Anna ZiekenhuisGeldrop, NetherlandsContact: J.M.W.E. WillemsTaking people
  • Admiraal de Ruyter ZiekenhuisGoes, NetherlandsContact: J. JansenTaking people
  • Rivas Beaterix ZiekenhuisGorinchem, NetherlandsContact: M.A. DavidisTaking people
  • Groene Hart ZiekenhuisGouda, NetherlandsContact: M. Cloos-van BalenTaking people
  • Martini ZiekenhuisGroningen, NetherlandsContact: R.P. VeenstraTaking people
  • Ommelander ZiekenhuisGroningen, NetherlandsContact: S.H.E.M. ClermontsTaking people
  • UMC GroningenGroningen, NetherlandsContact: G. HospersTaking people
  • Spaarne GasthuisHaarlem, NetherlandsContact: H.B.A.C. StockmannTaking people
  • Saxenburgh GroepHardenberg, NetherlandsContact: R. BlankenburghTaking people
  • St.JansdalHarderwijk, NetherlandsContact: A.P. Schouten van der VeldenTaking people
  • Frisius MC HeerenveenHeerenveen, NetherlandsContact: J. de BoerTaking people
  • Elkerliek ziekenhuisHelmond, NetherlandsContact: J.A. WegdamTaking people
  • Ziekenhuisgroep TwenteHengelo, NetherlandsContact: R. HoekstraTaking people
  • TergooiHilversum, NetherlandsContact: A. van der VeldenTaking people
  • Treant ZorggroepHoogeveen, NetherlandsContact: M. TentTaking people
  • Dijklander ZiekenhuisHoorn, NetherlandsContact: D.J.A. SonneveldTaking people
  • Frisius MC LeeuwardenLeeuwarden, NetherlandsContact: M.B. PoléeTaking people
  • AlrijneLeiden, NetherlandsContact: L.E.A.M.M. SpieringsTaking people
  • Leids Universitair Medisch CentrumLeiden, NetherlandsContact: K.C.M. PeetersTaking people
  • Maastricht UMCMaastricht, NetherlandsContact: L.B.J. ValkenburgTaking people
  • MaastroMaastricht, NetherlandsContact: M. BerbéeTaking people
  • St. Antonius ZiekenhuisNieuwegein, NetherlandsContact: M. LosTaking people
  • Canisius Wilhelmina ZiekenhuisNijmegen, NetherlandsContact: J.J.B. JanssenTaking people
  • Radboud UMCNijmegen, NetherlandsContact: J.H.W. de WiltTaking people
  • BernhovenOss, NetherlandsContact: R.W.M. SchrauwenTaking people
  • Laurentius ZiekenhuisRoermond, NetherlandsContact: G.H.E.J. VijgenTaking people
  • Bravis ZiekenhuisRoosendaal, NetherlandsContact: F. TerheggenTaking people
  • Erasmus MCRotterdam, NetherlandsContact: P.J. TanisTaking people
  • Franciscus Gasthuis & VlietlandRotterdam, NetherlandsContact: M. VerseveldTaking people
  • Ikazia ZiekenhuisRotterdam, NetherlandsContact: W.J. VlesTaking people
  • Maasstad ZiekenhuisRotterdam, NetherlandsContact: P.P.L.O CoeneTaking people
  • Zuyderland Medisch CentrumSittard, NetherlandsContact: B. ScholtesTaking people
  • Antonius ZiekenhuisSneek, NetherlandsContact: H. van CruijsenTaking people
  • ZorgSaamTerneuzen, NetherlandsContact: M.P.S. SieTaking people
  • Haaglanden MCThe Hague, NetherlandsContact: F.J.F. JeurissenTaking people
  • HagaZiekenhuisThe Hague, NetherlandsContact: D. HoutsmaTaking people
  • Ziekenhuis RivierenlandTiel, NetherlandsContact: M. Tjin-A-TonTaking people
  • Elisabeth-Tweesteden ZiekenhuisTilburg, NetherlandsContact: D.D.E ZimmermanTaking people
  • DiakonessenhuisUtrecht, NetherlandsContact: A. SchiphorstTaking people
  • UMC UtrechtUtrecht, NetherlandsContact: Miriam KoopmanTaking people
  • VieCuri Medisch CentrumVenlo, NetherlandsContact: J. KonstenTaking people
  • St. Jans GasthuisWeert, NetherlandsContact: N.A.J.B. PetersTaking people
  • Streekziekenhuis Koningin BeatrixWinterswijk, NetherlandsContact: L. van SteenselTaking people
  • Zaans Medisch CentrumZaandam, NetherlandsContact: G. MustersTaking people
  • IsalaZwolle, NetherlandsContact: J.W. de GrootTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Dutch Colorectal Cancer Group
Trial code
NCT02070146
Record updated
4 June 2026
Original description
Survival after colorectal cancer (CRC) diagnosis strongly depends on local tumor extent, lymph node involvement and the presence of distant metastases. However, there remains great inter-patient variability regarding treatment outcome. A combination of biochemical factors, histopathological features, genomic profile, environmental factors and other clinical factors are likely to influence prognosis and treatment effect, independent from tumor stage, but it is still unclear which, how, and to what extent these factors can influence tumor recurrence and mortality in both early stage (I-III) and late stage (IV) CRC, small bowel cancer and anal cancer.Read full original descriptionShow less

Prospective Data Collection Initiative on Colorectal Cancer - a Prospective Observational Cohort Study -

Survival after colorectal cancer (CRC) diagnosis strongly depends on local tumor extent, lymph node involvement and the presence of distant metastases. However, there remains great inter-patient variability regarding treatment outcome. A combination of biochemical factors, histopathological features, genomic profile, environmental factors and other clinical factors are likely to influence prognosis and treatment effect, independent from tumor stage, but it is still unclear which, how, and to what extent these factors can influence tumor recurrence and mortality in both early stage (I-III) and late stage (IV) CRC, small bowel cancer and anal cancer.

Although the results from prospective clinical trials will remain the backbone of evidence based medicine, this concerns a highly selected patient population since the large majority (85%-95%) of cancer patients do not participate in clinical trials for various reasons. It is unlikely that trial participation will significantly improve in the near future. This fact has the following implications: 1) It is highly desirable to validate the results from trials in the general patient population. However, this is complicated by the fact that the documentation of patients treated in general practice (i.e. outside the scope of clinical trials) is largely insufficient to provide comparable patient cohorts in terms of prognostic characteristics and treatment parameters. 2) There is an increased availability of novel technologies that provide molecular markers with potential prognostic and/or predictive value. To test the clinical value of these markers large numbers of patients are required which greatly exceeds the number of patients who consent to participate in prospective clinical trials. 3) as a result of rapid technical developments, a range of new minimally invasive treatment options are entering the market. These interventions have the potential to be of great benefit for patients in terms of improved local control, higher probability of complete tumor removal, less damage to surrounding tissue, faster recovery and less short and long term side effects. Still, the interventions will have to prove their effectiveness, safety and superiority (or non-inferiority) to standard cancer treatments on a patient level. A prospective observational cohort study has the great opportunity to fill this gap.

Inclusion: Age ≥ 18 years; Histological proof of colorectal, small bowel and anal cancer, or a strong suspicion after imaging; Informed consent for longitudinal observational data collection.

Exclusion: Mentally incompetent patients; Participation of patients to the PLCRC project does not exclude participation in any other ongoing or future study.

ClinicalTrials.gov NCT02070146