Colorectal cancer trials in Netherlands

In Netherlands 86 Also abroad 1930

86 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Where
Breda, Groningen, Maastricht
Age
18 years and over
People
1,020 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07549412 · EU 2025-524648-37-00
Phase 3Taking people
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Where
Amsterdam, Breda, Nijmegen, Rotterdam
Age
18 years and over
People
477 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06997497 · EU 2024-517232-22-00
Phase 1Taking people
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
Where
Amsterdam, Maastricht, Nijmegen, Utrecht
Age
18 years and over
People
340 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07213791 · EU 2025-521887-37-00
Phase 3Taking people
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Where
Amersfoort, Amsterdam, Nijmegen, Rotterdam, Tilburg, Utrecht
Age
18 years and over
People
1,000 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06662786 · EU 2024-513852-13-00
Phase 3Taking people
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Where
Amersfoort, Amsterdam, Nijmegen, Rotterdam, Tilburg
Age
18 years and over
People
700 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06750094 · EU 2024-513853-66-00
Phase 1/2Taking people
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Where
Amsterdam, Nijmegen, Utrecht
Age
18 years and over
People
560 worldwide
Run by
Genmab
See details and how to joinNCT03526835 · EU 2024-513627-16-01
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Where
Amersfoort, Groningen, Maastricht, Rotterdam
Age
18 years and over
People
700 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07284849 · EU 2025-523735-19-00
Phase 2Taking people
Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer
Where
Amsterdam
Age
18 years and over
People
100 worldwide
Run by
Solstice Oncology, Inc.
See details and how to joinNCT07808151 · EU 2026-527233-58-00
Phase 3Not yet taking people in Netherlands
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer.
Where
Arnhem, Rotterdam, Tilburg
Age
18 years and over
People
450 worldwide
Run by
Genmab A/S
See details and how to join2026-525883-17-00 · EU 2026-525883-17-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Amsterdam, Groningen, Nijmegen, Rotterdam, Utrecht
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Where
Amsterdam, Groningen, Tilburg, Utrecht
Age
18 years and over
People
990 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221357 · EU 2025-523224-45-00
Phase 2Taking people
Pan-tumor neoadjuvant basket study of immune check-point inhibition and novel IO combinations (NEOASIS)
Where
Amsterdam
Age
18 years and over
People
153
Run by
Netherlands Cancer Institute
See details and how to joinNCT06279130 · EU 2023-505756-21-00
Phase 2Taking people
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Where
The Hague
Age
18 years and over
People
140 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT07811193 · EU 2026-525507-26-00
Phase 2Taking people
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
Where
Leiden
Age
18 years and over
People
90 worldwide
Run by
Delcath Systems Inc.
See details and how to joinNCT06607458
Phase 1/2Taking people
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Where
Amsterdam, Maastricht, Rotterdam, Utrecht
Age
18 years and over
People
346 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06885034
No phaseTaking people
DETECT: Target Volume for Rectal Endoluminal Radiation Boosting
Where
Eindhoven, Maastricht
Age
18 years and over
People
50
Run by
Maastricht Radiation Oncology
See details and how to joinNCT04927897
No phaseTaking people
Registry Maastro Applicator
Where
Maastricht
Age
18 years and over
People
999
Run by
Maastricht Radiation Oncology
See details and how to joinNCT07501845
Phase 2Taking people
Can we Save the rectum by watchful waiting or transanal surgery following short- or long-course radioTherapy and Additional local oR systemic Treatment for early-stage REctal Cancer?
Where
Amsterdam, Arnhem, Breda, Capelle aan den IJssel, Deventer, Eindhoven, Groningen, Hoofddorp, Leeuwarden, Leiden, Maastricht, Nijmegen, Rotterdam, Tilburg, Utrecht, Zwolle
Age
18 years and over
People
280
Run by
Radboud universitair medisch centrum Stichting
See details and how to join2024-514620-17-00 · EU 2024-514620-17-00
Phase 3Taking people
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Where
Amsterdam
Age
18 years and over
People
800 worldwide
Run by
Pfizer
See details and how to joinNCT07222800 · EU 2025-523521-18-00
Phase 1Taking people
A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation
Where
Amsterdam
Age
18 years and over
People
130 worldwide
Run by
Bayer
See details and how to joinNCT07535112 · EU 2025-523648-11-00
Phase 3Taking people
ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer
Where
Almelo, Amersfoort, Amsterdam, Breda, Delft, Dordrecht, Eindhoven, Goes, Groningen, Hoorn Nh, Leeuwarden, Leiden, Nijmegen, Roosendaal, Rotterdam, 'S-Gravenhage, 'S-Hertogenbosch, Sneek, Terneuzen, Tilburg, Uden, Erasmus MC
Age
18 years and over
People
103
Run by
Erasmus Medical Center
See details and how to joinNCT07188025 · EU 2024-517700-12-00
Phase 3Taking people
A clinical trial of belzutifan and other treatments in people with solid tumors or von Hippel-Lindau (VHL)-related tumors (MK-6482-043)
Where
Amsterdam, Maastricht, Zwolle
Age
18 years and over
People
134 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to join2025-524160-38-00 · EU 2025-524160-38-00
Phase 2Taking people
Neoadjuvant Immune Checkpoint Inhibition and Novel IO Combinations in Early-stage Colon Cancer
Where
Amsterdam, Eindhoven, Haarlem, Hilversum, The Hague
Age
18 years and over
People
353
Run by
The Netherlands Cancer Institute
See details and how to joinNCT03026140 · EU 2024-513314-35-00
No phaseNot yet taking people in Netherlands
Endoscopic (EID) Versus Surgical (TAMIS) Local Excision for Early Stage Rectal Cancer
Where
Alkmaar, Almere Stad, Amersfoort, Amsterdam, Capelle aan den IJssel, Deventer, Eindhoven, Groningen, Haarlem, Hoorn, Leiden, Nieuwegein, Roermond, Rotterdam, The Hague, Utrecht, Zwolle
Age
18 years and over
People
246
Run by
Amsterdam UMC, location VUmc
See details and how to joinNCT07846046
Phase 3Taking people
Neoadjuvant FOLFOXIRI and Chemoradiotherapy versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy, followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer
Where
Amsterdam, Arnhem, Deventer, Eindhoven, Geldrop, Goes, Heerlen, Helmond, Leeuwarden, Maastricht, Nijmegen, Rotterdam, 'S-Gravenhage, 'S-Hertogenbosch, Utrecht, Veldhoven, Vlissingen, Weert, Zwolle
Age
18 years and over
People
394
Run by
Catharina Ziekenhuis Stichting
See details and how to joinNCT07472868 · EU 2025-523692-39-00