Watching Small Papillary Thyroid Cancers Instead of Immediate Surgery
Tests watching small thyroid cancers closely rather than operating right away, in adults.
Plain-language title generated from the registry record
Registry title: Active Surveillance of Papillary Thyroid Microcarcinoma
Key facts
- Where
- Los Angeles, United StatesSee the site
Where in United States
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Cedars-Sinai Medical Center
- Trial code
- NCT02609685
- Record updated
- 4 November 2026
- Original description
The purpose of this study is to better understand the outcomes of active surveillance (observation) instead of immediate surgery, which is the current standard of care for papillary thyroid microcarcinoma (PTMC). Patients with a 1.5 cm or smaller thyroid nodule(s) with papillary thyroid carcinoma will be eligible for the study.Read full original descriptionShow less
Active Surveillance of Papillary Thyroid Microcarcinoma
The purpose of this study is to better understand the outcomes of active surveillance (observation) instead of immediate surgery, which is the current standard of care for papillary thyroid microcarcinoma (PTMC). Patients with a 1.5 cm or smaller thyroid nodule(s) with papillary thyroid carcinoma will be eligible for the study.
Inclusion: Pathologically confirmed Bethesda V or VI thyroid nodules with papillary thyroid carcinoma or high clinical suspicion, or pathologically confirmed Bethesda III or IV nodules with BRAF mutation; 2.0 cm or smaller nodules by ultrasonographic criteria; Ability to understand and the willingness to sign a written informed consent and HIPAA Authorization form; Must be able to read and write English fluently to participate in the questionnaire portion of the study.
Exclusion: History of radiation to neck; High-grade or poorly differentiated PTC variants; Central or lateral neck lymphadenopathy suspicious for PTC; Unfavorable nodule location (e.g. Near dorsal surface (by recurrent laryngeal nerve); Adjacent to trachea (risk of cartilage invasion).