Thyroid cancer trials in United States

In United States 76 Also abroad 226

76 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Studies on Tumors of the Thyroid
Where
Bethesda
Age
6 months to 98 years
People
2,500
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT00001160
No phaseTaking people
Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer
Where
Bethesda
Age
7 years to 90 years
People
500
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT01109420
No phaseTaking people
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study
Where
Bethesda, Rockville
Age
1 month to 99 years
People
1,500
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01247597
Phase 2Taking people
The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer
Where
Bethesda
Age
18 years to 98 years
People
54
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT04927416
Phase 1/2Not yet taking people in United States
177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer
Where
Bethesda
Age
18 years to 100 years
People
18
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT06991738
No phaseTaking people
Nanosecond Pulsed Field Ablation in the Management of T1N0M0 Papillary Thyroid Carcinoma
Where
Houston, Sarasota
Age
18 years and over
People
15
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07218315
No phaseTaking people
Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms
Where
Bethesda
Age
4 years and over
People
2,415
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01005654
No phaseTaking people
Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions
Where
San Antonio
People
2,000
Run by
The University of Texas Health Science Center at San Antonio
See details and how to joinNCT03160274
No phaseTaking people
Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules
Where
Duarte
Age
18 years and over
People
1,450
Run by
City of Hope Medical Center
See details and how to joinNCT05229341
Phase 2Taking people
Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery
Where
Ann Arbor, Boston, Charlottesville, Cleveland, Houston
Age
18 years and over
People
45
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06959511
No phaseTaking people
Active Surveillance of Papillary Thyroid Microcarcinoma
Where
Los Angeles
Age
18 years and over
People
216
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT02609685
No phaseTaking people
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Where
Austin, Charleston, Cleveland, Corbin, Duarte, Elizabethtown, Florence, Gainesville, Lexington, Memphis, Miami, Minneapolis, Nashville, New Albany, Paducah, Portland, Rochester
Age
40 years and over
People
7,000
Run by
Adela, Inc
See details and how to joinNCT05366881
Phase 3Taking people
Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer
Where
Nashville
Age
18 years and over
People
100
Run by
Vanderbilt University Medical Center
See details and how to joinNCT05999630
Phase 2Taking people
The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer
Where
Bethesda
Age
18 years to 90 years
People
30
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT03841617
Phase 3Enrolling by invitation
Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored Study
Where
Bay Shore, Houston, Kettering, Memphis
People
5,000
Run by
Exelixis
See details and how to joinNCT07620574 · EU 2026-525795-26-00
No phaseTaking people
International PPB/DICER1 Registry
Where
Minneapolis
Age
0 Minutes to 100 years
People
3,400
Run by
Children's Hospitals and Clinics of Minnesota
See details and how to joinNCT03382158
Phase 2Taking people
Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer
Where
Boston, Houston, Memphis, Philadelphia, San Francisco, Seattle
Age
2 years to 99 years
People
13
Run by
Children's Hospital of Philadelphia
See details and how to joinNCT05783323
Phase 2Not yet taking people in United States
Pulsed Stereotactic Ablative Radiotherapy (PULSAR) With Systematic Therapy for Thyroid Cancer
Where
St Louis
Age
18 years and over
People
12
Run by
Washington University School of Medicine
See details and how to joinNCT07886905
No phaseNot yet taking people in United States
STAGE-MTC Trial Thyroid Lobectomy With Ipsilateral Central Neck Dissection
Where
Los Angeles
Age
18 years and over
People
100
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT07612293
Phase 2Taking people
A Study of Avutometinib and Defactinib in People With Thyroid Cancer
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
30
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06007924
Phase 1/2Taking people
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
Where
Boston, Denver, Houston, Miami, Nashville, San Antonio
Age
18 years and over
People
330
Run by
ModeX Therapeutics, An OPKO Health Company
See details and how to joinNCT06239194
No phaseNot yet taking people in United States
Personalized Cancer Support (Thrive Track) to Manage the Emotional Needs of Young Adults With Thyroid, Melanoma and Testicular Cancer, PerCS-YA Trial
Where
Ann Arbor
Age
20 years to 39 years
People
142
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT07529080
Phase 2Not yet taking people in United States
Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer
Where
Houston
Age
18 years and over
People
12
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07470489
Phase 1/2Taking people
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Where
Aurora, Boston, Cleveland, Durham, Fairfax, Gilbert, Grand Rapids, Houston, Los Angeles, Minneapolis, Nashville, New Haven, New York, San Antonio, San Francisco, Seattle, St Louis, Washington D.C.
Age
18 years and over
People
554 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT05786924 · EU 2025-523474-16-00
Phase 1Not yet taking people in United States
211At-MABG in Adults With Advanced Neuroendocrine Cancers
Where
Philadelphia
Age
18 years and over
People
16
Run by
University of Pennsylvania
See details and how to joinNCT07661420