TerminatedNo phase
Reliability of Pupil Response to Acute Pain
Key facts
- Who runs it
- Wake Forest University Health Sciences
- Where
- Winston-Salem, United StatesSee the site
- Trial code
- Status
- Terminated
- People taking part
- 20 people enrolled
- Started
- 4 Aug 2015
- Ended
- 16 Jun 2025
- Type of study
- Observational
- Record updated
- 31 July 2026
Who can take part
- Age
- 18 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Adult (18-70)
- Pain from hip or knee arthritis of moderate intensity
- American Society of Anesthesiologists physical status 1-3
Who cannot take part
- History of Raynaud's disease of the feet
- Psychotic disorder or a recent psychiatric hospitalization
- History of eye surgery or topical eye medications that would would directly affect pupil diameter
- Inability to complete study questionnaires
- Pregnancy
- Litigation or workers compensation related to hip or knee pain
- Taking > 50 mg morphine equivalents/day
Where in United States
- Wake Forest Baptist Medical CenterWinston-Salem, United StatesNo longer taking part
About the trial
What the trial wants to find out
The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.
The group in the trial
- Osteoarthritis
Study population to include adult men and women with osteoarthritis.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 31 July 2026