Osteoarthritis trials in United States

In United States 226 Also abroad 826

226 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
BioPoly® Partial Resurfacing Knee Implant IDE
Where
Chesterfield, Fort Wayne, Indianapolis, Louisville, Redwood City, Rochester
Age
30 years to 65 years
People
152
Run by
BioPoly LLC
See details and how to joinNCT06915363
No phaseTaking people
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success
Where
Los Angeles
Age
40 years and over
People
25
Run by
Lucas R. Cusumano, MD
See details and how to joinNCT07494838
Phase 2Not yet taking people in United States
LDRT Retreatment for Knee Osteoarthritis
Where
Madison
Age
40 years and over
People
112
Run by
University of Wisconsin, Madison
See details and how to joinNCT07933523
No phaseNot yet taking people in United States
Osteoarthritis Care Tools for Primary Care Providers in Family Medicine and Geriatrics Clinics
Where
Chapel Hill
Age
18 years to 99 years
People
205
Run by
University of North Carolina, Chapel Hill
See details and how to joinNCT07925710
No phaseTaking people
Effect of Anti-inflammatory Diet in Osteoarthritis
Where
San Diego
Age
18 years and over
People
72
Run by
University of California, San Diego
See details and how to joinNCT06080347
No phaseNot yet taking people in United States
The Feasibility of a Virtual/Home-based OA Treatment Program in Older Adults With OA and Multimorbidity
Where
Lebanon
Age
65 years and over
People
50
Run by
Dartmouth-Hitchcock Medical Center
See details and how to joinNCT07921563
No phaseTaking people
Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
Where
La Jolla
Age
18 years and over
People
30
Run by
University of California, San Diego
See details and how to joinNCT05559463
Phase 2Taking people
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Where
Austin, Aventura, Bay City, Bellevue, Birmingham, Boston, Bradenton, Chicago, Cincinnati, City of Saint Peters, Columbus, Coral Gables, Dallas, Dayton, DeLand, Duncansville, Fargo, Fort Worth, Glendale, Greensboro, Hamden, Idaho Falls, Irvine, Lady Lake, Maitland, Merritt Island, Methuen, Miami, Murray, New Bedford, New Orleans, New Port Richey, North Charleston, Ocala, Omaha, Orlando, Palm Springs, Phoenix, Pinellas Park, Plantation, Renton, Riverside, Rochester, San Antonio, San Diego, Springfield, Sunrise, Tempe, The Villages, Topeka, Tulsa, Waltham, Winter Park, Woodstock, Wyomissing
Age
18 years and over
People
10,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT05986292
Phase 3Taking people
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
Where
Ann Arbor, Birmingham, Charlotte, Chicago, Cincinnati, Columbus, Dallas, Deerfield Beach, El Cajon, Encinitas, Flushing, Houston, Jackson, Kenner, La Jolla, La Mesa, Lexington, McAllen, Morehead City, New York, Omaha, Parker, Redwood City, Rochester, Rochester Hills, Salt Lake City, San Antonio, San Francisco, Santa Monica, Scottsdale, Steamboat Springs, Tempe, Westwood
Age
18 years to 75 years
People
300
Run by
Medipost, Inc.
See details and how to joinNCT07339111
Phase 3Taking people
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
Where
Albuquerque, Charlottesville, Chicago, Clearwater, Colorado Springs, Dallas, Doral, Duncansville, Escondido, Farmington Hills, Fort Worth, Granite Quarry, Gretna, Houston, Jacksonville, Kingwood, Lady Lake, Monroe, Norman, Ocala, Rancho Cucamonga, Salisbury, Shavano Park, Sterling Heights, Stockbridge, Tampa, Tempe, Tomball, Tustin, Waco, Wichita, Wilmington, Woodstock
Age
18 years and over
People
656 worldwide
Run by
Pfizer
See details and how to joinNCT07919678 · EU 2026-526328-34-00
No phaseTaking people
EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
Where
Gainesville, Gastonia
Age
21 years and over
People
118
Run by
DePuy Orthopaedics
See details and how to joinNCT06631638
Phase 3Taking people
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Where
Ammon, Bellaire, Brooklyn, Buffalo, Burlington, Charlottesville, Chicago, Colorado Springs, Decatur, DeSoto, Evansville, Fort Worth, Fountain Valley, Houston, Jacksonville, Kirkland, Long Island City, Louisville, Mesa, Mobile, Newton, Phoenix, Plymouth Meeting, Quincy, Rochester, San Antonio, Santa Ana, Shavano Park, South Jordan, Spring Valley, St. Petersburg, Tucson, Tulsa, Walnut Creek, Weslaco, Winter Park, Woodstock
Age
18 years and over
People
900 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07353931 · EU 2025-523768-19-00
Phase 2Taking people
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
Where
Austin, Bay City, Bellevue, Birmingham, Bradenton, Chicago, City of Saint Peters, Dayton, DeLand, Duncansville, Fargo, Hamden, Lady Lake, Maitland, Merritt Island, Miami, New Bedford, New Orleans, New Port Richey, Ocala, Palm Springs, Phoenix, Renton, Riverside, Rochester, San Diego, Springfield, Sunrise, The Villages, Tulsa, Waltham, Winter Park, Woodstock
Age
40 years and over
People
150 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07641517
No phaseTaking people
Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty
Where
New York
Age
18 years and over
People
52
Run by
Columbia University
See details and how to joinNCT07845695
Phase 3Taking people
A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoarthritis and Overweight or Obesity With or Without Type 2 Diabetes (VESPER-OA 2)
Where
Birmingham, Miami, Shelby, Tucson
Age
18 years and over
People
756
Run by
Pfizer
See details and how to joinNCT07915609 · EU 2026-527180-15-00
No phaseTaking people
Study NRPT Feasibility in Knee Osteoarthritis
Where
San Diego
Age
18 years to 80 years
People
30
Run by
University of California, San Diego
See details and how to joinNCT07917403
No phaseNot yet taking people in United States
Boosting Exercise Adherence in Knee Osteoarthritis
Where
Durham
Age
18 years and over
People
360
Run by
VA Office of Research and Development
See details and how to joinNCT07219732
No phaseTaking people
Oral Nutritional Optimization in Total Joint Arthroplasty
Where
New York, Philadelphia
Age
55 years and over
People
72
Run by
NYU Langone Health
See details and how to joinNCT04210284
Phase 2Taking people
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
Where
Salt Lake City
Age
40 years to 80 years
People
40
Run by
University of Utah
See details and how to joinNCT06859164
No phaseTaking people
Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy
Where
Manhasset
Age
18 years to 85 years
People
40
Run by
Northwell Health
See details and how to joinNCT06965452
No phaseTaking people
SMR Stemless Reverse vs SMR Reverse Shoulder System
Where
Boca Raton, Chicago, Denver, Durham, East Syracuse, Fishers, Los Angeles, Orlando, Philadelphia, San Antonio, Sayre, Tampa
Age
22 years and over
People
200
Run by
Limacorporate S.p.a
See details and how to joinNCT04697004
Phase 4Taking people
Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA
Where
Cranberry Township
Age
18 years to 89 years
People
150
Run by
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
See details and how to joinNCT07430085
No phaseTaking people
Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain
Where
Springfield
Age
50 years to 64 years
People
235
Run by
Margaret L Gourlay, MD, MPH
See details and how to joinNCT07674901
No phaseNot yet taking people in United States
Study Comparing Osteoarthritis Programs
Where
Seattle
Age
50 years and over
People
200
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07896473
No phaseTaking people
Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
Where
Rochester
Age
50 years to 100 years
People
128
Run by
Mayo Clinic
See details and how to joinNCT06887829