Observational study of two ways of giving furosemide in acute heart failure
Observes continuous and intermittent furosemide infusion in adults admitted with acute heart failure.
Plain-language title generated from the registry record
Registry title: Loop Diuretic Therapy in Acutely Decompensated Heart Failure
Key facts
- Where
- Chioggia, Padova, Roma, and Siena, ItalySee the 4 sites
Where in Italy
- Ospedale Madonna della NavicellaChioggia, ItalyTaking people
- Azienda Ospedaliera di PadovaPadova, ItalyTaking people
- University of Rome La SapienzaRoma, ItalyTaking people
- Department of Internal Medicine, Cardiovascular Diseases UnitSiena, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Siena
- Trial code
- NCT02638142
- Record updated
- 8 August 2025
- Original description
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.Read full original descriptionShow less
Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure: Evaluation of Renal Function, Congestion Signs, BNP and Outcome
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.
Inclusion: Patients over 18 years; Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound); Blood BNP > 100 pg/mL; ADHF: Acute Decompensated Heart Failure; BNP: B-type Natriuretic Peptide; IV: IntraVenous; LVEF: Left Ventricular Ejection Fraction.
Exclusion: End-Stage renal disease or renal replacement therapy; Recent myocardial infarction (within thirty days of screening); Patients affected by sepsis, liver diseases, inflammatory diseases or neoplastic diseases; Creatinine levels > 4 mg/dL; Patients who receive more than 40 mg of IV furosemide; Systolic blood pressure < 80 mmHg.