Collects samples from adults with cancer or pre-cancer to study why treatments work differently
Collects tissue and blood samples from adults with several cancers.
Plain-language title generated from the registry record
Registry title: Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols
Key facts
- Where
- Bethesda, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 120 years old?
Source: NCT02682667, who can take part
Where in United States
- National Institutes of Health Clinical CenterBethesda, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Institute (NCI)
- Trial code
- NCT02682667
- Record updated
- 9 November 2026
- Original description
Background:Read full original descriptionShow less
Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols
Background:
Cancer has a major impact in the United States and across the world. In 2015, over 1.5 million new cases of cancer were diagnosed in the U.S. Researchers want to study samples from people with cancer or a pre-malignant condition. They hope to develop more effective treatments.
Objective:
To better understand the biology of malignancies and why certain cancers respond differently to treatment.
Eligibility:
Adults at least 18 years old with cancer or a pre-cancerous condition.
Design:
Participants will be screened with a medical history, physical exam, and blood tests. Their diagnosis will be confirmed by the NCI Laboratory of Pathology.
Participants will send tissue blocks or slides from their original tumor biopsy.
At least once, participants will have a medical history, physical exam, and blood and urine tests.
Participants may have the following tests. They may have them more than once:
Apheresis. A needle in one arm removes blood. Blood is run through a machine and the sample cells are taken out. The rest of the blood is returned by a needle in the other arm.
Bone marrow aspiration and biopsy. The hipbone will be numbed. A needle will be put into the hipbone. Bone marrow will be taken out through the needle.
Piece of cancer tissue taken by a needle and syringe.
Computed tomography (CT) scan, magnetic resonance imaging (MRI) and/or positron emission tomography (PET) scan or ultrasound to help locate their tumor. For the scans, they lie in a machine that takes pictures.
A small piece of skin removed.
Participants will be contacted by phone once a year to find out how they are doing.
Exclusion: Active concomitant medical or psychological illnesses that may increase the risk to the subject; Inability to provide informed consent; Pregnant or breastfeeding women.
INCLUSION CRITERIA:; Diagnosis of cancer, a premalignant/neoplastic condition or disease (such as an immunodeficiency) that increases the risk of being diagnosed with a cancer or premalignant/neoplastic condition; Age >=18 years of age; ECOG performance status of 0-3; Ability and willingness of subject to provide informed consent; Additional inclusion criteria pertinent only for participants undergoing apheresis; Hemoglobin >= 8 mg/dL and platelet count > 75 K/microL; Weight >= 48 kg; Central line in place or adequate venous access.