Multiple myeloma trials in United States

In United States 299 Also abroad 704

299 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols
Where
Bethesda
Age
18 years to 120 years
People
500
Run by
National Cancer Institute (NCI)
See details and how to joinNCT02682667
No phaseTaking people
Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma
Where
Buffalo
Age
18 years and over
People
265
Run by
Roswell Park Cancer Institute
See details and how to joinNCT05312255
Phase 3Taking people
A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma
Where
Charlotte, Durham, Gainesville, Houston, Lexington, Los Angeles, Louisville, Portland, Seattle, Stony Brook
Age
18 years and over
People
410 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT05730036 · EU 2022-501396-62-00
Phase 2Taking people
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Where
Grand Forks, Jacksonville
Age
18 years and over
People
220
Run by
Mayo Clinic
See details and how to joinNCT05969860
Phase 2Taking people
Engaging T-cells to Eliminate MRD in Newly Diagnosed Myeloma Optimizing Response With Talquetmab and Teclistamab (ROTATE)
Where
New Haven, Omaha, Rochester
Age
18 years and over
People
50
Run by
Noffar Bar
See details and how to joinNCT06993675
Phase 3Taking people
Belantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple Myeloma
Where
La Crosse
Age
18 years to 79 years
People
500
Run by
PrECOG, LLC.
See details and how to joinNCT07285239
No phaseTaking people
Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants
Where
Bethesda
Age
7 years to 80 years
People
1,000
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT00106925
Phase 1Taking people
A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments
Where
Atlanta, Boston, Chapel Hill, Columbus, Dallas, Detroit, Indianapolis, La Jolla, New York, Rochester, Seattle, Winston-Salem
Age
18 years and over
People
317 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT05137054 · EU 2023-506247-42-00
No phaseNot yet taking people in United States
Wearable Core Body Temperature Monitoring for Early Detection of Cytokine Release Syndrome in Outpatients Receiving CAR T-Cell Therapy
Where
Charlotte, Winston-Salem
Age
18 years and over
People
105
Run by
Wake Forest University Health Sciences
See details and how to joinNCT07911540
No phaseTaking people
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Where
Aberdeen, Aitkin, Akron, Albert Lea, Albuquerque, Allentown, Alma, Alpena, Alton, Amarillo, Ames, Anaconda, Anchorage, Anderson, Ankeny, Ann Arbor, Antigo, Appleton, Arroyo Grande, Asheville, Ashland, Augusta, Aurora, Aventura, Baker City, Bakersfield, Ballwin, Baltimore, Baraboo, Barberton, Bardstown, Barrington, Baton Rouge, Battle Creek, Baxter, Beavercreek, Belfast, Bellingham, Belpre, Bemidji, Bend, Berlin, Bethesda, Bethlehem, Biddeford, Billings, Bismarck, Bloomington, Boardman, Boise, Bolivar, Bonita Springs, Boone, Boulder, Bozeman, Brainerd, Branson, Braselton, Brewer, Brighton, Brownstown, Brunswick, Bryan, Burbank, Burien, Burlington, Burnsville, Caldwell, Cambridge, Canton, Cape Girardeau, Carbondale, Carmichael, Caro, Carson City, Carterville, Carthage, Cary, Cedar Rapids, Centennial, Centerville, Centralia, Chaska, Chelsea, Chesapeake, Chesterfield, Cheyenne, Chicago, Chillicothe, Cincinnati, Clackamas, Clarkston, Clearwater, Clinton, Clinton Township, Clive, Clyde, Cody, Coeur d'Alene, Colorado Springs, Columbia, Columbus, Concord, Coon Rapids, Coos Bay, Corbin, Council Bluffs, Creston, Crosslake, Crystal Lake, Cudahy, Danville, Dayton, Dearborn, Decatur, Deerfield Beach, Deer River, Delaware, Denver, Des Moines, Detroit, Detroit Lakes, Dixon, Downers Grove, Dublin, Duluth, Durango, Durham, East China Township, Easton, East Stroudsburg, Eau Claire, Edgewood, Edina, Edmonds, Effingham, Elgin, Elk Grove, Elmhurst, Elmira, Ely, Emeryville, Emmett, Englewood, Enumclaw, Eureka, Everett, Evergreen Park, Fairbanks, Fargo, Farmington, Farmington Hills, Federal Way, Findlay, Fishersville, Flint, Florence, Fond du Lac, Fort Collins, Fort Dodge, Fort Lauderdale, Fort Myers, Fort Smith, Fort Thomas, Fosston, Franklin, Freehold, Fridley, Fruitland, Gaffney, Gahanna, Gainesville, Galesburg, Garden City, Garner, Georgetown, Germantown, Gladwin, Glen Burnie, Glens Falls, Goldsboro, Grafton, Grand Forks, Grand Island, Grand Rapids, Great Bend, Great Falls, Greeley, Green Bay, Greenville, Greenwood, Greer, Grosse Pointe Woods, Grove City, Hackettstown, Harvey, Havre, Hayward, Hazel Crest, Hazleton, Helena, Henderson, Hendersonville, Hibbing, Hood River, Houma, Houston, Huntington, International Falls, Issaquah, Jackson, Jacksonville, Jamaica, Jamaica Plain, Jamestown, Janesville, Jefferson, Jefferson City, Joplin, Kalamazoo, Kalispell, Kansas City, Kearney, Kennewick, Kenosha, Kettering, Kewanee, Kingman, Lacey, La Crosse, Lakeland, Lakewood, Lancaster, Lansing, Laredo, Las Cruces, Las Vegas, Leavenworth, Lewisburg, Lexington, Libertyville, Lima, Lincoln, Little Rock, Littleton, Livonia, Loma Linda, London, Lone Tree, Long Beach, Longmont, Longview, Loveland, Macomb, Madison, Manchester, Mankato, Mansfield, Maple Grove, Maplewood, Marietta, Marinette, Marion, Marlette, Marrero, Marshalltown, Martinez, Marysville, Mattoon, Meadowbrook, Mechanicsville, Medford, Medina, Merced, Meridian, Metairie, Miami Beach, Midland, Midlothian, Milwaukee, Minneapolis, Minot, Missoula, Moline, Monticello, Moose Lake, Morristown, Mount Pleasant, Mount Sterling, Mount Vernon, Mukwonago, Mullica Hill, Murrells Inlet, Muskegon, Nags Head, Nampa, Napa, Neenah, New Albany, Newark, Newberg, New Brunswick, New London, New Orleans, New Richmond, Newton, New Ulm, New York, Niles, Norfolk, Normal, Norton Shores, Novi, Oakland, Oak Lawn, Ocean Pines, Oconomowoc, Oconto Falls, O'Fallon, Oklahoma City, Olney, Omaha, Ontario, Oregon City, Osage Beach, Oshkosh, Ottawa, Paducah, Pahrump, Papillion, Parker, Park Rapids, Park Ridge, Pekin, Pennington, Peoria, Pequot Lakes, Perrysburg, Peru, Phoenix, Phoenixville, Pine River, Pittsburg, Plant City, Pompton, Pontiac, Portland, Portsmouth, Port Townsend, Post Falls, Pottstown, Princeton, Providence, Pueblo, Racine, Raleigh, Rancho Mirage, Randallstown, Reading, Redmond, Reed City, Reno, Renton, Rhinelander, Richmond, Rio Rancho, Robbinsdale, Rockford, Rocklin, Rockport, Rolla, Royal Oak, Sacramento, Safety Harbor, Saginaw, Saint Cloud, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Salisbury, San Antonio, Sandpoint, Sandstone, Sanford, San Luis Obispo, Santa Cruz, Santa Maria, Santa Rosa, Savannah, Scarborough, Seattle, Sedro-Woolley, Shakopee, Shawano, Sheboygan, Shelton, Sheridan, Silverdale, Sioux Falls, Southfield, South Portland, Spartanburg, Spokane, Spooner, Springfield, Staples, Sterling Heights, Stevens Point, St. Helena, Stillwater, St Louis, Stockton, Stony Brook, St. Petersburg, Sturgeon Bay, Sullivan, Summit, Superior, Tacoma, Tampa, Tawas City, Thief River Falls, Thornton, Tifton, Toledo, Topeka, Towson, Traverse City, Troy, Twin Falls, Two Rivers, Union, Urbana, Vancouver, Vineland, Virginia, Virginia Beach, Waconia, Walla Walla, Walnut Creek, Warren, Warwick, Washington, Washington D.C., Waukee, Waukesha, Waupaca, Wausau, Wauwatosa, Weaverville, West Allis, West Bloomfield, West Branch, West Columbia, West Des Moines, Westerville, West Haven, Westminster, West Reading, Wichita, Wilkes-Barre, Willmar, Wilmington, Winter Haven, Wisconsin Rapids, Woodbury, Woodland, Worthington, Wyandotte, Wyoming, Yakima, Yelm, Yorkville, Youngstown, Ypsilanti, Zanesville
Age
40 years to 75 years
People
2,900
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT05334069
No phaseTaking people
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Where
Austin, Charleston, Cleveland, Corbin, Duarte, Elizabethtown, Florence, Gainesville, Lexington, Memphis, Miami, Minneapolis, Nashville, New Albany, Paducah, Portland, Rochester
Age
40 years and over
People
7,000
Run by
Adela, Inc
See details and how to joinNCT05366881
Phase 2Taking people
Testing the Investigational Medication Combination of Daratumumab and Teclistamab Compared to the Usual Treatment (Daratumumab, Pomalidomide, Dexamethasone or Daratumumab, Carfilzomib, Dexamethasone) for Patients With High-risk Multiple Myeloma Refractory or in First Relapse
Where
Anaconda, Baton Rouge, Billings, Bloomington, Canton, Carthage, Cedar Rapids, Coeur d'Alene, Decatur, Eureka, Galesburg, Great Falls, Kalispell, Kewanee, Macomb, Missoula, O'Fallon, Ottawa, Pekin, Peoria, Peru, Post Falls, Princeton, Sandpoint, Springfield, Washington
Age
18 years and over
People
80
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06948084
Phase 2Taking people
BCMA Bispecific Antibody Therapy for Post-BCMA CAR T-Cell Therapy Relapse (RECLAIM)
Where
Milwaukee
Age
18 years and over
People
34
Run by
Medical College of Wisconsin
See details and how to joinNCT07009899
Phase 1Taking people
FT836 CAR T-cell Therapy in Combination With Daratumumab in Patients With Relapsed and/or Refractory Multiple Myeloma
Where
Milwaukee
Age
18 years to 80 years
People
12
Run by
Medical College of Wisconsin
See details and how to joinNCT07221032
Phase 3Taking people
A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Where
Atlanta, Columbus, Dallas, Houston, New York, Stony Brook
Age
18 years and over
People
915 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07222761 · EU 2024-519504-27-00
Phase 3Taking people
A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)
Where
Atlanta, Boston, Columbus, Detroit, New York, Phoenix, Rochester, St Louis
Age
18 years and over
People
270 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07393282 · EU 2025-523252-31-00
No phaseEnrolling by invitation
Gene Therapy Follow-up Protocol for People Previously Enrolled in CAR-T Cell Studies
Where
Bethesda
Age
18 years and over
People
1,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT02473757
Phase 2Taking people
A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma
Where
Ann Arbor, Atlanta, Birmingham, Chicago, Duarte, Hollywood, Little Rock, Louisville, Nashville, New York, Portland, Rochester, St Louis
Age
18 years and over
People
510 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT04634552 · EU 2023-504581-29-00
Phase 4Taking people
A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel
Where
Atlanta, Boston, Buffalo, Charlotte, Chicago, Detroit, Duarte, Hackensack, Houston, Indianapolis, Milwaukee, Nashville, New Brunswick, New York, Philadelphia, Phoenix, Pittsburgh, Rochester, San Francisco, Stanford, St Louis, Tampa, The Bronx, Westwood
Age
18 years and over
People
295 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT05201781 · EU 2023-505530-10-00
Phase 3Taking people
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
Where
Ann Arbor, Baltimore, Bethesda, Charleston, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Clovis, Columbus, Dallas, Detroit, Duarte, Durham, East Brunswick, East Syracuse, Farmington, Fort Belvoir, Gilbert, Grand Rapids, Hershey, Hollywood, Houston, Irvine, Kansas City, Lake Success, Lebanon, Los Alamitos, Los Angeles, Louisville, Lubbock, Maywood, Mineola, Nashville, Newark, New Haven, Newnan, New York, Norfolk, Novi, Omaha, Orlando, Pittsburgh, Providence, Richmond, Salt Lake City, Santa Fe, Shreveport, Southfield, Tacoma, Tucson, Waukee, Weston, Wilmington, Winston-Salem
Age
18 years and over
People
1,590 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT05552222 · EU 2023-503442-30-00
Phase 1Taking people
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
Where
Charlotte, Denver, Duarte, Houston, Irvine, New York, Philadelphia, San Francisco
Age
18 years and over
People
180 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT05652335 · EU 2023-503679-12-00
No phaseTaking people
Pivotal Study to Validate a Novel System to Non-Invasively Detect Severe Neutropenia
Where
Boston, Hackensack, Honolulu, Houston, Louisville
Age
10 years and over
People
210 worldwide
Run by
Leuko Labs, Inc.
See details and how to joinNCT06323447
Phase 2Taking people
A Study to Evaluate Efficacy and Safety of Ciltacabtagene Autoleucel
Where
Charlotte, Cleveland, Iowa City, New York, San Francisco, Tampa, Winston-Salem
Age
18 years to 80 years
People
60 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07149857 · EU 2025-521975-30-00
Phase 3Taking people
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
Where
Ann Arbor, Atlanta, Austin, Baltimore, Boston, Brooklyn, Chapel Hill, Cleveland, Dallas, Denver, Duarte, Durham, Farmington, Fort Myers, Houston, Iowa City, Irvine, Jacksonville, Kansas City, Little Rock, Los Angeles, Louisville, Miami, Milwaukee, Mineola, Nashville, New Haven, New York, Philadelphia, Phoenix, Portland, Rochester, Salt Lake City, San Antonio, San Francisco, Tampa, Waukee, Zion
Age
18 years and over
People
400 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07258511 · EU 2025-522007-18-00
Phase 2Taking people
A Study Evaluating the Prophylactic Use of Tocilizumab to Prevent Cytokine Release Syndrome With Ramantamig Administration in Participants With Relapsed/Refractory Multiple Myeloma
Where
Beverly Hills, Columbus, Denver, Goodyear, Irvine, Nashville, Palo Alto, Salt Lake City, St Louis
Age
18 years and over
People
230 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07589634