Compares two dialysis salt levels in people with kidney failure
Tests two dialysis sodium levels in adults receiving maintenance haemodialysis for kidney failure.
Plain-language title generated from the registry record
Registry title: Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
Key facts
- Where
- Altrincham, Ashton-under-Lyne, Barnet, Barnsley, Bath, Bedford, Bexhill-on-Sea, Blackley, Bolton, Bradford, Bridgwater, Brighton, Bristol, Bromley, Broomfield, Cannock, Chesterfield, Clacton-on-Sea, Colchester, Coventry, Crawley, Crewe, Cromer, Darlington, Dartford, Dover, Edgware, Epsom, Exeter, Farnborough, Gloucester, Great Yarmouth, Grimsby, Harlow, Hayes, Honiton, Houghton Regis, Hull, Isleworth, Kingston, London, Ludlow, Macclesfield, Manchester, Margate, Middlesbrough, North Yorks, Northallerton, Nuneaton, Oldham, Plaistow, Polegate, Rochdale, Romford, Rotherham, Rugby, Salford, Scarborough, Scunthorpe, Sheffield, Shrewsbury, Smethwick, St Albans, Stafford, Stevenage, Stockport, Stockton-on-Tees, Stoke-on-Trent, Stratford-upon-Avon, Sutton, Taunton, Telford, Thornton Heath, Torquay, Tottenham, Wigan, Willesborough, Wolverhampton, Woolwich, Worthing, and York, United KingdomSee the 95 sites
- Phase
- Phase 4
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for dialysis units that treat adults on long-term haemodialysis. Each unit is randomly given one of two default dialysate sodium levels.
- Age
- 18 years or older (patients treated at the site).
- Sex
- All sexes.
- Disease stage
- Adults receiving maintenance haemodialysis (end-stage kidney disease).
- Earlier treatment
- The unit must use a default dialysate sodium concentration for most sessions. Fewer than 15% of patients withdrew for social reasons in the first two years of dialysis.
Main reasons for not taking part
- Unit with fewer than 10 dialysis recipients at the time of randomisation
- Unit that is not self-contained
- Home dialysis training or support unit
- Unit not willing to accept randomisation to either option
- Unit not able to comply with data collection methods
This trial only enrols participants on dialysis. The registry sentence this rests on: Predominantly dialyses adults (≥18 years old) receiving maintenance haemodialysis
Read by machine on 9 November 2026.
Where in United Kingdom
- Altrincham General Hospital Dialysis UnitAltrincham, United KingdomTaking people
- Tameside Renal Dialysis UnitAshton-under-Lyne, United KingdomTaking people
- Barnet Satellite UnitBarnet, United KingdomTaking people
- Barnsley Dialysis UnitBarnsley, United KingdomTaking people
- Bath Dialysis UnitBath, United KingdomTaking people
- Bedford Renal UnitBedford, United KingdomTaking people
- Bexhill Dialysis UnitBexhill-on-Sea, United KingdomTaking people
- Hexagon Towers Dialysis UnitBlackley, United KingdomTaking people
- Bolton Kidney Care CentreBolton, United KingdomTaking people
- St Luke's Hospital Renal WardBradford, United KingdomTaking people
- Bridgwater Dialysis UnitBridgwater, United KingdomTaking people
- Brighton Sussex Kidney UnitBrighton, United KingdomTaking people
- Cossham Dialysis UnitBristol, United KingdomTaking people
- South Bristol Dialysis UnitBristol, United KingdomTaking people
- Bromley Dialysis UnitBromley, United KingdomTaking people
- Broomfield HospitalBroomfield, United KingdomTaking people
- Cannock Haemodialysis UnitCannock, United KingdomTaking people
- Chesterfield Dialysis UnitChesterfield, United KingdomTaking people
- Clacton (Diaverum)Clacton-on-Sea, United KingdomTaking people
- Colchester (Diaverum)Colchester, United KingdomTaking people
- Clay LaneCoventry, United KingdomTaking people
- University Hospitals Coventry & Warwickshire Main UnitCoventry, United KingdomTaking people
- Crawley Dialysis UnitCrawley, United KingdomTaking people
- LeightonCrewe, United KingdomTaking people
- Cromer Hospital Dialysis UnitCromer, United KingdomTaking people
- Darlington Dialysis UnitDarlington, United KingdomTaking people
- Dartford Dialysis UnitDartford, United KingdomTaking people
- Dover Renal UnitDover, United KingdomTaking people
- Edgware Satellite UnitEdgware, United KingdomTaking people
- Epsom Dialysis UnitEpsom, United KingdomTaking people
- HeavitreeExeter, United KingdomTaking people
- Farnborough Dialysis UnitFarnborough, United KingdomTaking people
- Cotswold Dialysis CentreGloucester, United KingdomTaking people
- SevernGloucester, United KingdomTaking people
- James Paget Renal UnitGreat Yarmouth, United KingdomTaking people
- Grimsby Renal UnitGrimsby, United KingdomTaking people
- Harlow Renal UnitHarlow, United KingdomTaking people
- Hayes HospitalHayes, United KingdomTaking people
- HonitonHoniton, United KingdomTaking people
- Chiltern Renal UnitHoughton Regis, United KingdomTaking people
- Fresenius Hull Dialysis UnitHull, United KingdomTaking people
- West MiddlesexIsleworth, United KingdomTaking people
- Kingston Satellite Dialysis UnitKingston, United KingdomTaking people
- Collierswood Dialysis UnitLondon, United KingdomTaking people
- King George HospitalLondon, United KingdomTaking people
- Mary Rankin Satellite UnitLondon, United KingdomTaking people
- North Wandsworth Dialysis UnitLondon, United KingdomTaking people
- Royal London HospitalLondon, United KingdomTaking people
- Whipps Cross HospitalLondon, United KingdomTaking people
- Ludlow Dialysis UnitLudlow, United KingdomTaking people
- Macclesfield District General HospitalMacclesfield, United KingdomTaking people
- Manchester Royal Infirmary Renal Dialysis UnitManchester, United KingdomTaking people
- Octagon Renal SatelliteManchester, United KingdomTaking people
- Margate Renal UnitMargate, United KingdomTaking people
- James CookMiddlesbrough, United KingdomTaking people
- North OrmesbyMiddlesbrough, United KingdomTaking people
- HarrogateNorth Yorks, United KingdomTaking people
- Friarage HospitalNorthallerton, United KingdomTaking people
- Lucy Deane (George Eliot)Nuneaton, United KingdomTaking people
- Oldham Dialysis UnitOldham, United KingdomTaking people
- Newham HospitalPlaistow, United KingdomTaking people
- Eastbourne (Polegate) Dialysis UnitPolegate, United KingdomTaking people
- Rochdale Dialysis UnitRochdale, United KingdomTaking people
- Queen's HospitalRomford, United KingdomTaking people
- Rotherham Dialysis UnitRotherham, United KingdomTaking people
- St Cross (Ash Unit)Rugby, United KingdomTaking people
- Salford Renal UnitSalford, United KingdomTaking people
- ScarboroughScarborough, United KingdomTaking people
- Scunthorpe Dialysis CentreScunthorpe, United KingdomTaking people
- Peter Moorhead UnitSheffield, United KingdomTaking people
- Renal G FloorSheffield, United KingdomTaking people
- Sheffield Dialysis UnitSheffield, United KingdomTaking people
- Shrewsbury Renal UnitShrewsbury, United KingdomTaking people
- Smethwick Dialysis CentreSmethwick, United KingdomTaking people
- St Albans Dialysis UnitSt Albans, United KingdomTaking people
- County HospitalStafford, United KingdomTaking people
- Lister Renal UnitStevenage, United KingdomTaking people
- Stockport NHS Dialysis UnitStockport, United KingdomTaking people
- North TeesStockton-on-Tees, United KingdomTaking people
- Royal StokeStoke-on-Trent, United KingdomTaking people
- Stratford Dialysis CentreStratford-upon-Avon, United KingdomTaking people
- St. Helier Dialysis UnitSutton, United KingdomTaking people
- Sutton Dialysis UnitSutton, United KingdomTaking people
- Taunton Dialysis CentreTaunton, United KingdomTaking people
- Hollinswood House Renal UnitTelford, United KingdomTaking people
- Croydon Dialysis UnitThornton Heath, United KingdomTaking people
- South Devon Satellite Kidney UnitTorquay, United KingdomTaking people
- Tottenham Hale Satellite UnitTottenham, United KingdomTaking people
- Wigan Renal UnitWigan, United KingdomTaking people
- Ashford Renal UnitWillesborough, United KingdomTaking people
- Pond Lane Dialysis UnitWolverhampton, United KingdomTaking people
- Woolwich Dialysis UnitWoolwich, United KingdomTaking people
- Worthing Dialysis UnitWorthing, United KingdomTaking people
- EasingwoldYork, United KingdomTaking people
- York HospitalYork, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sydney
- Trial code
- NCT02823821
- Record updated
- 4 April 2025
- Original description
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.Read full original descriptionShow less
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.
The site inclusion criteria are:; Predominantly dialyses adults (≥18 years old) receiving maintenance haemodialysis; Rates of withdrawal within the first two years of commencing dialysis for social reasons have been less than 15% for the 2 years prior to recruitment and are not expected to increase above 15%; Has a minimum of 10 dialysis recipients at time of randomisation; Utilises a default dialysate sodium concentration at the time of recruitment (a substantial majority of dialysis sessions are conducted with the default dialysate sodium concentration); Is a self-contained unit (i.e. unit patients do not regularly rotate through another unit. Brief trips by patients to a parent or other unit do not exclude a site); Willing to accept randomisation to either intervention (as determined by nominated Director of Unit); Is not a home dialysis training or support unit. [Sites that include both in-center/satellite dialysis patients and home patients may participate but the study procedures and assessments will only be conducted in the incenter/satellite component of the site]; The exclusion criteria are:; Not able to comply with data collection methods.