Studying adults with hormone gland conditions, including genetic causes
Studies adults with suspected hormone-related conditions, and their relatives, to understand genetic causes.
Key facts
- Who runs it
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Where
- Bethesda, United StatesSee the site
- Trial code
- Registry title
- Evaluation of Adults With Endocrine and Metabolic-Related Conditions
- Status
- Recruiting
- People taking part
- 1,250 people, planned
- Started
- 9 Jul 2016
- Expected to end
- 31 Dec 2029
- Type of study
- Observational
- Record updated
- 28 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a known or suspected endocrine (hormone gland) or metabolic disorder. Adult relatives can also join if needed to diagnose a family member.
- Age
- 18 Years to 100 Years
- Sex
- All sexes can join.
- Disease stage
- A known or suspected endocrine disorder. The study doctors choose who joins.
Main reasons for not taking part
- Anyone under the age of 18 years old
- Medical, physical, mental or social conditions that make joining a poor choice for the person, in the doctors' view
- Being critically ill or unstable
- Severe organ failure that may limit the hormone tests
The registry criteria, word for word
Show all 5 criteriaShow less
Who cannot take part
- Any medical, physical, psychiatric, or social conditions, which, in the opinion of the investigators, would make participation in this protocol not in the best interest of the subject. Subjects who are critically ill, unstable, or with severe organ failure that may affect/limit the endocrine evaluation and place unsustainable demands on Clinical Center or NIDDK resources
- Anyone under the age of 18 years old
Other criteria
- INCLUSION CRITERIA:
- Participants with known or suspected endocrine disorder age 18 years and older are eligible for this protocol. Protocol investigators will make the actual selection of subjects most appropriate for clinical evaluation
- Relatives ages 18 years and older may be enrolled if clinically indicated for the diagnosis of a proband
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Where in United States
- National Institutes of Health Clinical CenterBethesda, United StatesContact: NIDDK DiabetesAndEndocrineClinicTaking people
About the trial
What the trial wants to find out
Background:
Read full original descriptionShow less
There are many endocrine and metabolic-related conditions. Two well-known disorders include diabetes and thyroid disease. Some of these diseases are caused by a change in genes. Researchers want to identify the genes involved in these disorders. They hope this will help them learn more about these diseases.
Objectives:
To learn more about conditions that affect the hormone-secreting glands (endocrine glands) in adults. To train doctors to diagnose and treat people with endocrine or metabolic conditions.
Eligibility:
Adults age 18 years and older with a known or suspected endocrine disorder.
Relatives ages 18 years and older.
Doctors will review all requests and available medical records to determine final eligibility for the protocol.
Design:
Participants will have a medical history and physical exam.
Most participants will have 1 visit, and may have follow up visits if necessary. They may have tests, surgery, or other procedures to help diagnose or treat their condition. These could include:
* Blood, urine, and saliva tests * Imaging tests. These may include X-ray, ultrasound, or scans. * Sleep study * Medical photographs * Visits with other specialists at NIH
Participants will provide blood, urine, saliva, or tissue samples. Some of these samples may be stored in the freezer for future studies.
Participants may be asked to participate in genetic testing. They will give a blood or saliva sample for this.
The group in the trial
- Adults with known or suspected endocrine or metabolic dissorde
Adults with known or suspected endocrine or metabolic dissorders
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of Adults With Endocrine-Related Conditions
- Plain-language title
- Studying adults with hormone gland conditions, including genetic causesGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Fit questions
- Built from NCT02830308, who can take part
- Publications
- Endothelial Dysfunction in Youth-Onset Type 2 Diabetes: A Clinical Translational Study.Circulation research, 2024
- Record updated
- 28 September 2026