Eye imaging and computer models to predict corneal treatment response in keratoconus
Uses eye imaging and computer simulations to predict cornea changes in keratoconus or refractive error.
Key facts
- Who runs it
- The Cleveland Clinic
- Where
- Cleveland, United StatesSee the site
- Trial code
- Registry title
- Corneal Elastography and Patient Specific Modeling
- Status
- Recruiting
- People taking part
- 60 people, planned
- Started
- May 2016
- Expected to end
- May 2027
- Type of study
- Observational
- Treatments tested
- Optical coherence tomography
- Record updated
- 3 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people with keratoconus, a thinning and bulging of the clear front of the eye, or people planned for LASIK eye surgery. Their eyes will be imaged to study how the cornea responds to treatment.
- Age
- 16 Years to 80 Years
- Sex
- All sexes can join
- Disease stage
- Keratoconus diagnosed by standard criteria, such as a steep corneal shape and irregular astigmatism typical of keratoconus. Or a vision error where the person is a candidate for LASIK and scheduled for surgery.
Main reasons for not taking part
- Unable to give informed consent
- Non-English speaking, if no interpreter is available
- Cognitive or mental impairment, if no legal guardian is available
The registry criteria, word for word
Show all 3 criteriaShow less
Who can take part
- Any patient with keratoconus diagnosed by standard criteria, including topographic steepness, irregular astigmatism with a pattern consistent with keratoconus
- Any patient deemed a candidate for LASIK (laser vision correction) and scheduled for surgery
Who cannot take part
- Inability to provide informed consent, including non-English speaking (if interpreter not available) and cognitively/mentally impaired (if legal guardian not available)
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 16 and 80 years old?
Where in United States
- Cleveland Clinic Foundation-Cole Eye InstituteCleveland, United StatesContact: Pamela Hoffman, MSTaking people
About the trial
What the trial wants to find out
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. Patients who either 1) have keratoconus and are being evaluated for corneal crosslinking or 2) have refractive error and are being evaluated for refractive surgery procedures such as LASIK will have their eyes imaged to assess their mechanical properties and will have computational simulations performed to predict the response to treatment. One aim of the study is to test the hypothesis that computational models can predict the cornea's shape changes within clinically acceptable limits of error.
Treatments tested
- Optical coherence tomography
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Corneal Elastography and Patient Specific Modeling
- Plain-language title
- Eye imaging and computer models to predict corneal treatment response in keratoconusGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 15 November 2026.
- Fit questions
- Built from NCT03030755, who can take part
- Record updated
- 3 June 2026