Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis
Key facts
- Who runs it
- Johns Hopkins University
- Where
- Baltimore, United StatesSee the site
- Trial code
- Status
- Completed
- Phase
- Phase 2
- People taking part
- 58 people enrolled
- Started
- 1 Nov 2017
- Ended
- 27 Nov 2023
- Type of study
- Interventional, 4 groups
- Treatments tested
- Blinded study medication
- Record updated
- 11 December 2024
Who can take part
- Age
- 45 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Diagnosis of knee osteoarthritis
- Urine sample tests negative for common illicit substances of abuse (e.g., cannabis)
- Medically cleared to take study medications
- Are not pregnant or breast feeding
- Willing to comply with the study protocol
Who cannot take part
- Presence of any clinically significant medical/psychiatric illness judged by the investigators to put subject at elevated risk for experiencing an adverse event
- Known allergy to the blinded study medications
- Pain other than Knee Osteoarthritis
- Taking opioids for pain
- Prescribed and taking gabapentinoid, Tricyclic Antidepressants (TCA), venlafaxine, duloxetine, stimulants or benzodiazepines
Where in United States
- Johns HopkinsBaltimore, United StatesNo longer taking part
About the trial
What the trial wants to find out
This research is being done to evaluate whether combining medications that are FDA approved, but have not yet been approved for combination treatment, can be effective in reducing pain.
The 4 groups in the trial
- Arm 1Treatment being tested
Blinded study medication. This is a within-subject study so all session procedures will be identical. The specific medications administered that study day will be the only change each session. Study days will last approximately 8 hours and will be conducted on an outpatient basis. Participants will be asked to complete standardized pain testing procedures, do brief physical functioning testing, undergo blood draws and complete questionnaires and cognitive testing at multiple points over the course of each study visit.
Treatment: Blinded study medication
- Arm 2Treatment being tested
Blinded study medication. Participants will be asked to complete standardized pain testing procedures, do brief physical functioning testing, undergo blood draws and complete questionnaires and cognitive testing at multiple points over the course of each study visit.
Treatment: Blinded study medication
- Arm 3Treatment being tested
Blinded study medication. Participants will be asked to complete standardized pain testing procedures, do brief physical functioning testing, undergo blood draws and complete questionnaires and cognitive testing at multiple points over the course of each study visit.
Treatment: Blinded study medication
- Arm 4Treatment being tested
Blinded study medication. Participants will be asked to complete standardized pain testing procedures, do brief physical functioning testing, undergo blood draws and complete questionnaires and cognitive testing at multiple points over the course of each study visit.
Treatment: Blinded study medication
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Maximizing Analgesia to Reduce Pain Sensitivity in Chronic Knee Osteoarthritis Pain Patients
- Publications
- Record updated
- 11 December 2024