Taking people in United StatesNo phase
Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis
Key facts
- Who runs it
- The Cleveland Clinic
- Where
- Cleveland, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 20 people, planned
- Started
- 3 Aug 2017
- Expected to end
- 30 Sept 2028
- Type of study
- Observational, 2 groups
- Treatments tested
- blood draw and muscle biopsy
- Record updated
- 24 September 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- The diagnosis of cirrhosis based on liver biopsy and/or clinical, biochemical, and imaging criteria
- Patients with Child Pugh score from A5- to B7
- Control group: Subject in control group should have serum ALT and AST within normal range
Who cannot take part
- recent surgery (bowel resection or Gastric bypass operation)
- diabetes
- cancer
- kidney failure
- Advanced cardiac or pulmonary disease
- patient with thyroid disease \& Coagulopathy ( INR >1.4 and platelet count <80,000/ml)
- pregnancy
Where in United States
- Cleveland Clinic FoundationCleveland, United StatesContact: Annette Bellar, MSLATaking people
About the trial
What the trial wants to find out
To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.
The 2 groups in the trial
- Patients with Cirrhosis
Patients with a diagnosis of cirrhosis will have a blood draw and muscle biopsy will be performed.
Treatment: blood draw and muscle biopsy
- controls
control group should have serum ALT and AST within normal range and a blood draw and muscle biopsy will be performed
Treatment: blood draw and muscle biopsy
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Multiple Tracer Using Single Muscle Biopsy Technique in Evaluating Protein Synthesis and Break Down in Muscles of Cirrhotic Patients
- Record updated
- 24 September 2026