Liver cirrhosis trials in United States

In United States 79 Also abroad 358

79 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting
Where
Cleveland
Age
18 years to 70 years
People
40
Run by
The Cleveland Clinic
See details and how to joinNCT03121404
Phase 3Taking people
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
Where
Akron, Amarillo, Arlington, Atlanta, Aurora, Austin, Baltimore, Bastrop, Bellaire, Bethesda, Birmingham, Bradenton, Brandon, Brooklyn, Brownsville, Buffalo, Chandler, Chapel Hill, Charleston, Charlotte, Chicago, Clarksville, Clinton Township, Colorado Springs, Columbia, Conway, Coral Gables, Coronado, Corpus Christi, Covington, Cutler Bay, Dallas, Daytona Beach, Denison, Doral, Dothan, Durham, Edinburg, Englewood, Escondido, Fayetteville, Flagstaff, Flowood, Folsom, Fort Myers, Fort Sam Houston, Fort Worth, Fountain Valley, Gainesville, Garland, Hammond, Henderson, Hermitage, Hershey, Hialeah Gardens, Houma, Houston, Indianapolis, Inverness, Jackson, Jonesboro, Kansas City, Kingwood, Lady Lake, Lafayette, Lakewood Rch, Lancaster, Largo, Las Vegas, Lehigh Acres, Little Rock, Long Beach, Los Angeles, Louisville, Madison, Manhasset, Margate, Marietta, Marrero, Metairie, Miami, Miami Gardens, Morehead City, Naples, Nashville, New Haven, Newport Beach, New Port Richey, New York, Norfolk, North Little Rock, Novi, Ocala, Oklahoma City, Orange, Orlando, Pasadena, Pembroke Pines, Peoria, Pharr, Philadelphia, Pittsburgh, Raleigh, Redwood City, Richmond, Riverview, Roanoke, Rochester, Sacramento, San Antonio, San Francisco, San Jose, Sarasota, Scottsdale, Seattle, Shreveport, Snellville, Somers Point, South Bend, South Dartmouth, Southfield, Sparta, Springboro, Statesville, St Louis, Sugar Land, Summerville, Tarzana, Temple Terrace, Topeka, Tucson, Vancouver, Venice, Viera, Waco, Washington D.C., Webster, West Des Moines, Westlake, West Monroe, Weston, Wichita Falls, Zephyrhills
Age
18 years to 80 years
People
2,150 worldwide
Run by
Akero Therapeutics, Inc
See details and how to joinNCT06528314
Phase 3Taking people
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Where
Arlington, Atlanta, Austin, Bastrop, Bellaire, Bradenton, Brandon, Bristol, Brooklyn, Brooksville, Brownsville, Canoga Park, Chandler, Chattanooga, Chula Vista, Clarksville, Clinton Township, Colorado Springs, Columbia, Columbus, Coral Gables, Coronado, Cutler Bay, Dallas, Denison, Englewood, Fayetteville, Flourtown, Fort Myers, Fountain Valley, Garden City, Garland, Georgetown, Greenville, Hammond, Hershey, Hialeah, Hialeah Gardens, Homestead, Houston, Huntington Park, Inglewood, Kansas City, Lady Lake, La Mesa, Lancaster, Las Vegas, Laurelton, Lewisville, Macon, Mansfield, Marrero, McAllen, Mentor, Miami, Miami Lakes, Minneapolis, Montclair, Nashville, New Port Richey, New York, Omaha, Orange, Orlando, Oxnard, Palmetto Bay, Pembroke Pines, Peoria, Poway, Raleigh, Rialto, Richmond, Riverdale, Riverview, Rochester, San Antonio, San Bernardino, San Diego, Scottsdale, Seattle, Shreveport, South Bend, Spokane, Springboro, St. Petersburg, Summerville, Tampa, The Villages, Tucson, Tulsa, University Park, Waco, Warren Township, West Des Moines, Westlake, Wichita Falls, Winter Park, Wyoming, Wyomissing, Zephyrhills
Age
18 years and over
People
1,590 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06632457 · EU 2024-513741-36-00
Phase 2Taking people
A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)
Where
Arlington, Baltimore, Carrollton, Chandler, Charleston, Colorado Springs, Columbus, Coronado, Dallas, Fort Worth, Houston, Iowa City, Jacksonville, Kansas City, La Mesa, Los Angeles, Miami, Miami Lakes, Montclair, Morehead City, Nashville, New York, Rochester, San Antonio, University Park
Age
18 years to 75 years
People
30 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07325526
No phaseTaking people
VIATORR® TIPS Study Evaluating 6-10mm Diameters (VIATIPS)
Where
Atlanta, Cleveland, Dallas, Minneapolis
Age
18 years and over
People
152 worldwide
Run by
W.L.Gore & Associates
See details and how to joinNCT07390344
Phase 2Taking people
Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Where
Arlington, Austin, Dallas, Danville, Doral, Fort Myers, Georgetown, Houston, Indianapolis, Marrero, Metairie, Miami, Nashville, Pasadena, Rialto, San Antonio, Sugar Land, Topeka, Tucson
Age
18 years to 75 years
People
360 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07631637 · EU 2026-525916-33-00
No phaseTaking people
CirrhosisRx CDS System
Where
San Francisco
Age
18 years and over
People
2,106
Run by
University of California, San Francisco
See details and how to joinNCT05967273
Phase 2Taking people
A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH
Where
Austin, Baltimore, Chandler, Dallas, Fayetteville, Fresno, Georgetown, Houston, Kansas City, Lancaster, Marietta, Mesa, Miami, New York, Pasadena, Pearland, Rialto, Richmond, San Antonio, Santa Maria, Tucson, Viera, Waco, Wilson
Age
18 years to 75 years
People
42
Run by
GlaxoSmithKline
See details and how to joinNCT06920043
Phase 3Taking people
A Pivotal Clinical Study to Investigate the Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH)
Where
Arlington, Austin, Bellaire, Cape Coral, Dallas, Folsom, Fort Myers, Hialeah, Homestead, Humble, Kissimmee, Lakeland, Little Rock, Manassas, Miami, Morehead City, New York, Ocala, San Antonio, Santa Maria, St Louis, University Park, Waco, West Jordan, Westlake
Age
18 years to 75 years
People
1,740 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07701993
Phase 3Taking people
A Study to Investigate Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH)
Where
Arcadia, Arlington, Arroyo Grande, Austin, Bellaire, Cape Coral, Dallas, East Syracuse, Folsom, Fort Myers, Hialeah, Homestead, Houston, Humble, Kissimmee, Lakeland, Little Rock, Manassas, Miami, Morehead City, New York, Ocala, San Antonio, Springboro, St Louis, University Park, Van Nuys, Waco, West Jordan, Westlake
Age
18 years to 75 years
People
380 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07704892
Phase 2Taking people
High Dose Albumin in Refractory Ascites
Where
Houston
Age
18 years and over
People
100
Run by
Baylor College of Medicine
See details and how to joinNCT05867602
Phase 2Taking people
Study of AZD2389 Safety, Tolerability, and Pharmacodynamics in Adults With Steatotic Liver Disease and Advanced Fibrosis
Where
Austin, Chandler, Clarksville, Denison, Fresno, Georgetown, Houston, Jupiter, Kansas City, Las Vegas, Miami, Morehead City, Port Orange, Raleigh, San Antonio, St Louis, Tucson, Westlake, Yukon
Age
18 years and over
People
104 worldwide
Run by
AstraZeneca
See details and how to joinNCT07610837
No phaseTaking people
Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias
Where
Rochester
Age
19 years and over
People
30
Run by
Mayo Clinic
See details and how to joinNCT06306963
No phaseTaking people
Evaluation of Non-Invasive Tests for Metabolic Liver Disease
Where
Bellaire, Columbus, Miami, San Antonio
Age
18 years to 75 years
People
400
Run by
Foundation for the National Institutes of Health
See details and how to joinNCT07122700
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH
Where
Akron, Albany, Albuquerque, Amarillo, Ann Arbor, Asheville, Athens, Atlanta, Austin, Baltimore, Bellevue, Birmingham, Brownsville, Burlington, Camarillo, Canoga Park, Chandler, Charleston, Charlotte, Chicago, Cincinnati, Clermont, Cleveland, Clinton Township, Columbia, Columbus, Cordova, Coronado, Dayton, DeSoto, Detroit, Durham, East Greenwich, Edinburg, Farmers Branch, Fayetteville, Flagstaff, Florham Park, Flowood, Fort Myers, Fort Worth, Fountain Valley, Framingham, Fresno, Gainesville, Georgetown, Glen Burnie, Glenview, Greenbelt, Greenville, Hammond, Harlingen, Hermitage, Hialeah Gardens, Homestead, Homewood, Houston, Huntington Park, Iowa City, Jacksonville, Kansas City, Lady Lake, Lafayette, La Jolla, Lake Charles, Lakewood Rch, Las Vegas, Lehigh Acres, Lewisville, Liberty Township, Little Rock, Littleton, Los Angeles, Louisville, Lubbock, Maitland, Mansfield, Marietta, Miami, Minneapolis, Nashville, New Albany, New Port Richey, New York, North Little Rock, Ocala, Ocoee, Orlando, Pasadena, Pearland, Peoria, Philadelphia, Phoenix, Pittsburgh, Poway, Rapid City, Redwood City, Rialto, Richmond, Rochester, Sacramento, San Antonio, Sandy City, San Marcos, Santa Ana, Seattle, Somers Point, South Bend, Southlake, St Louis, Sun City, Tacoma, Topeka, Tucson, Tupelo, Tyler, University Park, Viera, Waco, West Jordan, Westlake, West Monroe, Winston-Salem, Winter Park, Wyoming, Ypsilanti
Age
18 years to 75 years
People
1,800 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06419374 · EU 2023-510395-31-00
Phase 1/2Taking people
Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer
Where
Chicago
Age
18 years and over
People
59
Run by
Devalingam Mahalingam
See details and how to joinNCT07042919
Phase 4Taking people
Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease
Where
Cleveland
Age
18 years to 70 years
People
70
Run by
The Cleveland Clinic
See details and how to joinNCT07058155
No phaseTaking people
Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
Where
Charlestown
Age
18 years to 99 years
People
45
Run by
Massachusetts General Hospital
See details and how to joinNCT06265272
No phaseNot yet taking people in United States
AGED Diagnostics Clinical Validation Study
Where
Bethesda
Age
18 years to 75 years
People
500
Run by
Active Genomes Expressed Diagnostics, Corp
See details and how to joinNCT07867574
No phaseTaking people
Blood Collection Biorepository for Liver Disease Research
Where
Buffalo
Age
7 years and over
People
1,000
Run by
State University of New York at Buffalo
See details and how to joinNCT03025074
Phase 2Taking people
Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk
Where
Boston, Dallas
Age
18 years and over
People
60
Run by
Raymond Chung
See details and how to joinNCT05028829
No phaseTaking people
HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease
Where
Boston
Age
18 years and over
People
30
Run by
Massachusetts General Hospital
See details and how to joinNCT05205954
No phaseTaking people
EUS-Guided Coil and Glue vs Glue Injection for Bleeding Gastric Varices in Cirrhosis
Where
Orlando
Age
19 years and over
People
110 worldwide
Run by
Medanta, The Medicity, India
See details and how to joinNCT07855913
No phaseNot yet taking people in United States
The Application of Lifestyle Enhancing Validated Integrative Therapies for Everyday Pain in Cirrhosis
Where
Ann Arbor, Baltimore, Miami, Nashville, New York, Philadelphia, Rochester, San Francisco
Age
18 years and over
People
625
Run by
University of Pennsylvania
See details and how to joinNCT07792850
No phaseTaking people
HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis
Where
Cleveland
Age
21 years to 65 years
People
24
Run by
The Cleveland Clinic
See details and how to joinNCT05166499