Studying why some headaches become chronic over time
Looks at brain scans, fluid and blood samples in people with chronic headaches.
Key facts
- Who runs it
- Stanford University
- Where
- Stanford, United StatesSee the site
- Trial code
- Registry title
- Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
- Status
- Recruiting
- People taking part
- 700 people, planned
- Started
- 12 Dec 2014
- Planned end
- 1 Sept 2026
- Type of study
- Observational, 3 groups
- Record updated
- 23 July 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults willing to complete online questionnaires in English. It studies why some people with episodic headache develop chronic daily headache.
- Age
- 18 Years and older
- Sex
- All sexes can join.
Main reasons for not taking part
- Any neurological condition, at the discretion of the Principal Investigator
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- Subjects must agree to sign informed consent
- Subject must be able to or at least with some help willing to complete online questionnaires in English
- Willing to comply with study instructions
- must speak and understand English
Who cannot take part
- *Any neurological condition, at the discretion of the Principal Investigator (PI)
Where in United States
- Stanford University School of MedicineStanford, United StatesContact: Bharati Sanjanwala, M.Sc.Taking people
About the trial
What the trial wants to find out
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal fluid, blood products, genetics, and patient phenotypes that might help explain this process.
The 3 groups in the trial
- Episodic Headache
Participants experiencing headache of any type more than twice per year but less than 15 days per month. No interventions
- Chronic Headache
Participants experiencing headache more than 15 days per month for at least three consecutive months. No interventions
- Control
Participants reporting fewer than two headaches per year. No interventions
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- SunStar Project to Explore the Chronification Process in Headache Through Functional Imaging, Deep Phenotyping, and Analysis of CSF of Blood Products
- Plain-language title
- Studying why some headaches become chronic over timeGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 23 July 2025