Compares two surgical reconnection methods in people with Crohn's disease
Compares two bowel reconnection surgeries in adults with Crohn's disease needing resection.
Plain-language title generated from the registry record
Registry title: Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis
Key facts
- Where
- Florence, Naples, and Rozzano, ItalySee the 3 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Source: NCT03256240, who can take part
Where in Italy
- Azienda Ospedaliero-Universitaria CareggiFlorence, ItalyTaking people
- Policlinico University HospitalNaples, ItalyTaking people
- Humanitas University HospitalRozzano, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Weill Medical College of Cornell University
- Trial code
- NCT03256240
- Record updated
- 14 May 2026
- Original description
This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial. Patients with Crohn's ileitis or Crohn's ileocolitis requiring resection will be randomized to undergo either the Kono-S anastomosis or the side-to-side functional end anastomosis.Read full original descriptionShow less
Prospective Randomized Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis in the Prevention of Post-operative Recurrence of Crohn's Disease
This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial. Patients with Crohn's ileitis or Crohn's ileocolitis requiring resection will be randomized to undergo either the Kono-S anastomosis or the side-to-side functional end anastomosis.
Inclusion: Patients with Crohn's ileitis or ileocolitis requiring initial surgical resection; Age of 18 years and older, male and female; All Phenotypes of Crohn's diisease will be included: nonpenetrating (B1), stricturing (B2), and penetrating (fistulating) (B3), according to the Vienna classification; The patients can be on any medications coming into surgery, including prior anti- tumor necrosis factor(TNF) therapy.
Exclusion: Patients that need change of surgical procedure as per the surgeon at the time of the intraoperative abdominal evaluation; Patients with more than one non-contiguous site of active disease, thus requiring multiple resections or additional bowel sparing procedures at the time of surgery; Patients with Crohn's disease extending to the cecum and ascending colon; Patients under 18 years of age; Patients with recurrent Crohn's; Pregnant patients; Patients who will need preventive postoperative medical treatment.