Compares two surgical reconnection methods in people with Crohn's disease
Compares two bowel reconnection surgeries in adults with Crohn's disease needing resection.
Plain-language title generated from the registry record
Registry title: Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis
Key facts
- Where
- Florence, Naples, and Rozzano, ItalySee the 3 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with Crohn's disease of the last part of the small bowel (ileitis) or of the small bowel and colon (ileocolitis) who need bowel surgery for the first time. It compares two ways of joining the bowel after surgery.
- Age
- 18 to 90 years
- Sex
- Men and women
- Disease stage
- Crohn's ileitis or ileocolitis needing a first surgical resection. All disease types can join: nonpenetrating (B1), stricturing (B2) and penetrating (fistulating) (B3).
- Earlier treatment
- Any medicines before surgery are allowed, including earlier anti-TNF therapy.
Main reasons for not taking part
- Recurrent Crohn's disease
- Pregnant patients
- More than one separate site of active disease needing several resections or other bowel-sparing procedures
- Crohn's disease reaching the cecum and ascending colon
- Need for preventive medical treatment after surgery
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Source: NCT03256240, who can take part
Where in Italy
- Azienda Ospedaliero-Universitaria CareggiFlorence, ItalyContact: Stefano Scaringi, MDTaking people
- Policlinico University HospitalNaples, ItalyContact: Gaetano Luglio, MDTaking people
- Humanitas University HospitalRozzano, ItalyContact: Annalisa Maroli, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Weill Medical College of Cornell University
- Trial code
- NCT03256240
- Record updated
- 14 May 2026
- Original description
This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial. Patients with Crohn's ileitis or Crohn's ileocolitis requiring resection will be randomized to undergo either the Kono-S anastomosis or the side-to-side functional end anastomosis.Read full original descriptionShow less
Prospective Randomized Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis in the Prevention of Post-operative Recurrence of Crohn's Disease
This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial. Patients with Crohn's ileitis or Crohn's ileocolitis requiring resection will be randomized to undergo either the Kono-S anastomosis or the side-to-side functional end anastomosis.
Inclusion: Patients with Crohn's ileitis or ileocolitis requiring initial surgical resection; Age of 18 years and older, male and female; All Phenotypes of Crohn's diisease will be included: nonpenetrating (B1), stricturing (B2), and penetrating (fistulating) (B3), according to the Vienna classification; The patients can be on any medications coming into surgery, including prior anti- tumor necrosis factor(TNF) therapy.
Exclusion: Patients that need change of surgical procedure as per the surgeon at the time of the intraoperative abdominal evaluation; Patients with more than one non-contiguous site of active disease, thus requiring multiple resections or additional bowel sparing procedures at the time of surgery; Patients with Crohn's disease extending to the cecum and ascending colon; Patients under 18 years of age; Patients with recurrent Crohn's; Pregnant patients; Patients who will need preventive postoperative medical treatment.