Heart Failure and Aortic Stenosis Transcriptome
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 75 years old?
Where in Italy
- Milan · Ospedale San RaffaeleTaking people
- San Donato Milanese · IRCCS Policlinico San DonatoTaking people
The registry text, word for word
Study of the Transcriptomic Alterations in Heart Failure and Aortic Stenosis
This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.
Inclusion: Non end-stage heart failure; left ventricle restoration surgery (SVR); End Systolic Volume Index (ESVI) >35 ml/m2; Ejection Fraction (EF)<40%; previous transmural anterior myocardial infarction (MI); age: 40-75; End-stage heart failure; left ventricle assisted device (LVAD) surgery; age: 40-75; Ejection Fraction (EF) <25%; End Systolic Volume Index (ESVI)≥60 ml/m2; Aortic Stenosis; aortic valve replacement; intracardial pressure difference >40 mmHg; septal diameter ≥1.3 cm.
Exclusion: End-stage heart failure; EF>25%; Time from MI unknown; Pregnancy; Other genetic diseases; Neoplasms; Collagenopathies; Chemo/radiotherapy; Prolonged use of corticosteroids; Infections; Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive; Aortic Stenosis; coronaropathies; Pregnancy; Other genetic diseases; Neoplasms; Collagenopathies; Chemo/radiotherapy; Prolonged use of corticosteroids; Infections; Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive; Non end-stage heart failure; End Systolic Volume Index (ESVI)<35 ml/m2; Ejection Fraction (EF)>40%; Time from MI unknown; Pregnancy; Other genetic diseases; Neoplasms; Collagenopathies; Chemo/radiotherapy; Prolonged use of corticosteroids; Infections; Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive.