Studies brain wiring in children with drug-resistant focal epilepsy
Looks at how seizure activity relates to brain wiring in children with focal epilepsy.
Plain-language title generated from the registry record
Registry title: Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Fondation Ophtalmologique A. de RothschildParis, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondation Ophtalmologique Adolphe de Rothschild
- Trial code
- NCT03268824
- Record updated
- 5 January 2026
- Original description
Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities. Whether ongoing seizure activity contributes to network pathology is a matter of debate. This study intends to measure the impact of seizures on structural connectivity on a local and on a global level. In children examined with intracerebral electrodes to evaluate whether a surgical cure can be proposed, we combine intracerebral stereotactic electroencephalography (EEG) recordings with diffusion weighted imaging of white matter fibers. On the local level, the study will quantify the number of deficient connections in the seizure onset zone. On a global level, the study will compare the white matter fibers of the left and right hemisphere to probe whether physiological language lateralization is preserved.Read full original descriptionShow less
Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain: Combination of Intracerebral Stereotactic Electroencephalography Recording and Diffusion Tensor Imaging in Children With Drug-resistant Focal Epilepsy
Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities. Whether ongoing seizure activity contributes to network pathology is a matter of debate. This study intends to measure the impact of seizures on structural connectivity on a local and on a global level. In children examined with intracerebral electrodes to evaluate whether a surgical cure can be proposed, we combine intracerebral stereotactic electroencephalography (EEG) recordings with diffusion weighted imaging of white matter fibers. On the local level, the study will quantify the number of deficient connections in the seizure onset zone. On a global level, the study will compare the white matter fibers of the left and right hemisphere to probe whether physiological language lateralization is preserved.
Inclusion: Drug resistant focal epilepsy; without drug resistant focal epilepsy.
Exclusion: Bi-hemispherical epilepsy or affecting multiple lobes; Autistic disorders; Severe mental retardation (IQ < 50); Lack of French-language skills; Contraindications to MRI; Severe mental retardation (IQ < 50); Lack of French-language skills; Contraindications to MRI; Congenital pathology altering cerebral connectivity; Parenchymal brain lesions; Unilateral or bilateral blindness; Unilateral or bilateral deafness.