Epilepsy trials in France

In France 80 Also abroad 451

80 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Not yet taking people in France
AAV9-ASAH1 intracisterna magna Gene Therapy (GNT0009) in Patients with Spinal Muscular Atrophy with Progressive Myoclonic Epilepsy (SMA - PME)
Where
Le Kremlin Bicetre Cedex, Paris
Age
Up to 17 years
People
3
Run by
Genethon
See details and how to join2026-527323-10-00 · EU 2026-527323-10-00
Phase 3Taking people
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Where
Bron, Lille Cedex, Paris, Rennes, Strasbourg Cedex 2
Age
12 years and over
People
160 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05667142 · EU 2022-502286-16-00
Phase 3Taking people
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
Where
Bron, Lille Cedex, Paris, Rennes, Strasbourg Cedex 2
Age
18 years and over
People
360 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05716100 · EU 2022-502281-25-00
Phase 3Enrolling by invitation
An Open-label Study of XEN1101 in Epilepsy
Where
Bron, Lille Cedex, Paris, Rennes, Strasbourg Cedex 2
Age
12 years and over
People
880 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05718817 · EU 2022-502282-24-00
No phaseTaking people
Multi-biomarkers in DEE
Where
Marseille
Age
0 years to 55 years
People
200 worldwide
Run by
Istituto Giannina Gaslini
See details and how to joinNCT07909382
No phaseTaking people
Long-Term Epilepsy Outcomes in Children With a History of Perinatal Stroke
Where
Strasbourg
Age
5 years to 25 years
People
120
Run by
University Hospital, Strasbourg, France
See details and how to joinNCT07898397
No phaseTaking people
Study of the Link Between Structural Alterations in the Hypothalamus and Cardiac Dysautonomia in Drug-resistant Epilepsy
Where
Amiens
Age
18 years and over
People
20
Run by
Centre Hospitalier Universitaire, Amiens
See details and how to joinNCT07888543
No phaseTaking people
Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
Where
Amiens, Bordeaux, La Tronche, Le Kremlin-Bicêtre, Lille, Lyon, Nancy, Paris, Rennes, Strasbourg, Toulouse
Age
18 years to 65 years
People
440
Run by
University Hospital, Toulouse
See details and how to joinNCT06105645
Phase 3Enrolling by invitation
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
Where
Bron, Lille, Marseille, Paris, Strasbourg, Toulouse
Age
2 years to 66 years
People
324 worldwide
Run by
Longboard Pharmaceuticals
See details and how to joinNCT06908226 · EU 2024-514974-39-00
Phase 1/2Taking people
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
Where
Marseille, Paris
Age
2 years to 12 years
People
20 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT07227857 · EU 2024-513332-17-00
No phaseTaking people
Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity
Where
Bron
Age
18 years to 55 years
People
50
Run by
Hospices Civils de Lyon
See details and how to joinNCT07249034
No phaseTaking people
Impact of Canine Mediation Practice in Psychomotor Therapy on Improving the Quality of Life in Adult Epileptic Patients.
Where
Saint-Étienne-de-Saint-Geoirs, Tain-l'Hermitage
Age
18 years and over
People
76
Run by
Fondation Ophtalmologique Adolphe de Rothschild
See details and how to joinNCT06898749
No phaseTaking people
Epilepsy and Driving
Where
Tain-l'Hermitage
Age
18 years to 65 years
People
40
Run by
Fondation Ophtalmologique Adolphe de Rothschild
See details and how to joinNCT07026591
No phaseTaking people
National Survey on Physical and Sports Activity of Adults With Epilepsy
Where
Tain-l'Hermitage
People
400
Run by
Fondation Ophtalmologique Adolphe de Rothschild
See details and how to joinNCT07075380
Phase 2Taking people
Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epilepsy Video-EEG Monitoring
Where
Paris
Age
6 years to 50 years
People
600
Run by
Fondation Ophtalmologique Adolphe de Rothschild
See details and how to joinNCT07318870
Phase 2Taking people
Efficacy of probenecid on cluster seizures during dosage reduction of Anti Seizure Medication (ASM) in presurgical focal epilepsy video-EEG monitoring
Where
Bron, Grenoble Cedex 9, Lille Cedex, Marseille, Paris, Rennes, Rouen Cedex, Toulouse
Age
Up to 64 years
People
192
Run by
Fondation A De Rothschild
See details and how to join2024-519133-29-00 · EU 2024-519133-29-00
No phaseTaking people
Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients
Where
Paris
Age
18 years and over
People
80
Run by
Institut National de la Santé Et de la Recherche Médicale, France
See details and how to joinNCT04653012
No phaseTaking people
Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy
Where
Bron
Age
18 years to 55 years
People
20
Run by
Hospices Civils de Lyon
See details and how to joinNCT07599150
Phase 3Not yet taking people in France
Efficacy of FLUOXETINE in children with drug-resistant, complex and rare epilepsy (FLUOXEPIL)
Where
Bordeaux, Lyon Cedex 04, Marseille, Montpellier Cedex 5, Paris, Toulouse Cedex 9
Age
Up to 17 years
People
100
Run by
Centre Hospitalier Regional De Marseille
See details and how to join2024-519897-38-01 · EU 2024-519897-38-01
No phaseNot yet taking people in France
Study of the Intracerebral Electrophysiological Signature in the Epileptic Patient
Where
Toulouse
Age
18 years to 65 years
People
75
Run by
University Hospital, Toulouse
See details and how to joinNCT07796984
Phase 3Not yet taking people in France
COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"
Where
Paris
Age
2 years and over
People
438 worldwide
Run by
Yale University
See details and how to joinNCT07281027
Phase 2Not yet taking people in France
A Multicenter, Open-Label, Long-Term, Safety and Tolerability Extension Study of PTI5803 as adjunctive therapy in patients ≥ 14 years of age with drug-resistant seizures associated to focal cortical dysplasia.
Where
Bron, Marseille, Paris, Tain-L'hermitage
Age
Up to 64 years
People
15
Run by
PannTheraPi
See details and how to join2026-525161-40-00 · EU 2026-525161-40-00
No phaseTaking people
SLC6A1-NDD Prospective Longitudinal Natural History Study
Where
Strasbourg
Age
Up to 17 years
People
60 worldwide
Run by
UCB Biopharma SRL
See details and how to joinNCT07531511
Phase 3Taking people
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
Where
Loos
Age
1 month and over
People
70 worldwide
Run by
UCB Biopharma SRL
See details and how to joinNCT04715646
Phase 2Not yet taking people in France
A Phase 2a, multi centric, open label clinical study to explore the safety and tolerability, the pharmacokinetics and pharmacodynamics profile and first signs of efficacy of PTI5803 administered as adjunctive therapy with a 3-dose escalation regimen in patients >= 14 years of age with drug-resistant seizures associated to focal cortical dysplasia, followed by an optional open-label extension study.
Where
Bron, Marseille, Paris, Tain-L'hermitage
Age
Up to 64 years
People
15
Run by
PannTheraPi
See details and how to join2026-525162-21-00 · EU 2026-525162-21-00