Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI
Key facts
- Where
- Edmonton, Halifax, Hamilton, London, Montreal, Ottawa, Saint John, and Sherbrooke, CanadaSee the 9 sites
Where in Canada
- Mazankowski Alberta Heart InstituteEdmonton, CanadaContact: Kenneth Quadros, MD (principal investigator)Taking people
- QEII Health Sciences CenterHalifax, CanadaContact: Ratika Parkash, MD (principal investigator)Taking people
- Hamilton Health Sciences CorporationHamilton, CanadaContact: Madhu Natarajan, MD (principal investigator)Taking people
- London Health Sciences Center (LHSC)London, CanadaContact: Jaimie Manlucu, MD (principal investigator)Taking people
- CIUSSS du Nord de l'Île de MtlMontreal, CanadaContact: Rémi Kouz, MD (principal investigator)Taking people
- Montreal Heart InstituteMontreal, CanadaContact: lena Rivard, MD, MScTaking people
- University of Ottawa Heart Institute (UOHI)Ottawa, CanadaContact: Mehrdad Golian, MD (principal investigator)Taking people
- New Brunswick Heart CenterSaint John, CanadaContact: Satish Toal, MD (principal investigator)Not yet recruiting
- Centre Hospitalier Universitaire de SherbrookeSherbrooke, CanadaContact: Benoît Daneault, MD (principal investigator)Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Montreal Heart Institute
- Trial code
- NCT03303612
- Record updated
- 14 October 2026
- Original description
The primary hypothesis of the proposed study is that an electrophysiology-based algorithmic approach is superior to standard clinical follow-up with 30-day monitoring in reducing the combined endpoint of syncope, hospitalization, and death in patients in patients with new of left bundle branch block following transcatheter aortic valve implantation (TAVI).Read full original descriptionShow less
Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI)
The primary hypothesis of the proposed study is that an electrophysiology-based algorithmic approach is superior to standard clinical follow-up with 30-day monitoring in reducing the combined endpoint of syncope, hospitalization, and death in patients in patients with new of left bundle branch block following transcatheter aortic valve implantation (TAVI).
Inclusion: Age ≥18 years; Informed consent to participate; Persistent new-onset LBBB after TAVI implantation (i.e. present at day 2).
Exclusion: Prior pacemaker or implantable cardioverter-defibrillator; Pre-existing right bundle branch block (RBBB) or LBBB (i.e., prior to TAVI); Class I or IIA indication for PPM implantation according to management guidelines.