Tests CPAP breathing device for high blood pressure lying flat in autonomic failure
Tests whether a breathing device lowers lying-down blood pressure in adults with autonomic failure.
Key facts
- Who runs it
- Vanderbilt University Medical Center
- Where
- Nashville, United StatesSee the site
- Trial code
- Registry title
- Treatment of Supine Hypertension in Autonomic Failure (CPAP)
- Status
- Recruiting
- People taking part
- 12 people, planned
- Started
- 21 Sept 2017
- Expected to end
- 21 Jan 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- continuous positive airway pressure (CPAP)
- Placebo
- Record updated
- 9 November 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with autonomic failure who also have high blood pressure when lying down (supine hypertension). It tests whether CPAP lowers their blood pressure.
- Age
- 18 to 85 years
- Sex
- Women and men can join.
- Disease stage
- Autonomic failure with high blood pressure when lying down (supine hypertension).
Main reasons for not taking part
- Medical students
- Pregnant women
- High-risk patients, for example heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction
- History of serious allergies or asthma
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- Patients with autonomic failure and with supine hypertension from all races
Who cannot take part
- High-risk patients (e.g. heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)
- History of serious allergies or asthma
- All medical students
- Pregnant women
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Where in United States
- Autonomic Dysfunction Center/ Vanderbilt University Medical CenterNashville, United StatesContact: Emily C Smith, RNTaking people
About the trial
What the trial wants to find out
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. The purpose of this study is to assess whether continuous positive airway pressure (CPAP) decreases blood pressure in autonomic failure patients with supine hypertension.
The 2 groups in the trial
- Placebo pill or patch or sham CPAPPlacebo, for comparison
Treatment: Placebo
- CPAP (continuous positive airway pressure)Existing treatment, for comparison
Continuous positive airway pressure during the night
Treatment: continuous positive airway pressure (CPAP)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Treatment of Supine Hypertension in Autonomic Failure With Continuous Positive Airway Pressure
- Plain-language title
- Tests CPAP breathing device for high blood pressure lying flat in autonomic failureGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT03312556, who can take part
- Record updated
- 9 November 2026