Comparing two lung imaging scans in people with chronic obstructive pulmonary disease
Compares a new xenon-129 lung MRI with xenon-133 scans in people with COPD.
Plain-language title generated from the registry record
Registry title: Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Key facts
- Where
- Charlottesville, United StatesSee the site
- Phase
- Phase 1/2
Where in United States
- University of Virginia Health SystemCharlottesville, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Virginia
- Trial code
- NCT03331302
- Record updated
- 4 November 2020
- Original description
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.Read full original descriptionShow less
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.
Inclusion: Subjects must have a diagnosis of COPD; at their clinical baseline on the day of imaging; must be clinically stable in order to participate in the study; COPD subjects will be categorized according to the GOLD; Current/Former SmokerSubjects; must have a smoking history ≥ 10 pack years.
Exclusion: Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning; History of respiratory infection within 2 weeks prior to the MR scan; History of congenital cardiac disease, chronic renal failure, or cirrhosis; History of MI, stroke and/or poorly controlled hypertension; Dx of asthma; Continuous oxygen use at home; Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging; FEV1 percent predicted less than 25%; Pregnancy or lactation; Subjects with any implanted device that cannot be verified as MRI compliant will be excluded; Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches; Inability to understand simple instructions or to hold still for approximately 10 seconds.