COPD trials in United States

In United States 122 Also abroad 557

122 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Study Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis
Where
Boerne, Charlotte, Columbus, DuBois, Encino, McKinney, Medford, Miami, North Charleston, Rincon, Rock Hill, Seattle, Spartanburg, Tomball, Union, Westminster
Age
40 years to 80 years
People
402 worldwide
Run by
UCB Biopharma SRL
See details and how to joinNCT07725939 · EU 2026-525523-25-00
Phase 3Taking people
Ensifentrine (MK-5884) Study for the Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations in Adults With a History of Moderate or Severe Exacerbations While Receiving Standard of Care (SOC) (MK-5884-031/RPL554/ENHANCE-3)
Where
Charleston, Chattanooga, Hialeah Gardens, Loxahatchee Groves, The Bronx, Valparaiso, Victoria
Age
40 years to 80 years
People
2,136
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07874815 · EU 2026-526255-61-00
Phase 2/3Not yet taking people in United States
An Open-Label Extension Study to Evaluate Inhaled Treprostinil SMI in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD)
Where
Boston, Chapel Hill, Charleston, Chicago, Dallas, Detroit, Falls Church, Lexington, Palo Alto, Philadelphia, Phoenix, Pittsburgh, San Francisco, Tucson
Age
18 years and over
People
400
Run by
United Therapeutics
See details and how to joinNCT07923526
Phase 2Not yet taking people in United States
Study of Treprostinil Administered Via Soft Mist Inhaler (SMI) in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD)
Where
Birmingham, Boston, Chapel Hill, Charleston, Chicago, Dallas, Detroit, Falls Church, Lexington, Palo Alto, Philadelphia, Phoenix, Pittsburgh, San Francisco, Tucson
Age
18 years and over
People
40
Run by
United Therapeutics
See details and how to joinNCT07923591
No phaseTaking people
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
Where
Birmingham, Columbus, Detroit, DuBois, Jacksonville, Milwaukee, Philadelphia, Pittsburgh, Richmond, Salem
Age
40 years to 80 years
People
200
Run by
Nuvaira, Inc.
See details and how to joinNCT07051707
No phaseTaking people
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
Where
Ann Arbor, Columbus, Murray, New Haven, Philadelphia, Seattle, Tucson, Winston-Salem
Age
18 years and over
People
500
Run by
Ohio State University
See details and how to joinNCT07558265
Phase 2Taking people
A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
Where
Birmingham, Boston, Denison, Denver, DuBois, Houston, Indianapolis, Kirkland, Lewisville, Maplewood, Miami, Miami Lakes, Muncie, Newport Beach, Orlando, San Diego, Southfield, Westchester
Age
40 years to 75 years
People
606 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07759245 · EU 2026-525480-41-00
Phase 3Taking people
A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Moderate to Very Severe COPD (PERSIST COPD-2)
Where
Cape Coral, Greenacres City, Miami, New York, Rapid City, Spokane, Tampa, West Point
Age
40 years to 80 years
People
624
Run by
GlaxoSmithKline
See details and how to joinNCT07780656
Phase 3Taking people
A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Moderate to Very Severe COPD (PERSIST COPD-1)
Where
Doral, Humble, Huntsville, Lake Charles, West Jordan
Age
40 years to 80 years
People
624 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07780669
No phaseNot yet taking people in United States
Reducing Exposure With Air Cleaners and Technology
Where
Berkeley, San Francisco
Age
13 years and over
People
100
Run by
University of California, Berkeley
See details and how to joinNCT07914010
Phase 2Taking people
Rademikibart IV for Acute Asthma and COPD Exacerbation
Where
Miami, St Louis
Age
18 years to 85 years
People
40
Run by
Connect Biopharm LLC
See details and how to joinNCT07705737
Phase 1Not yet taking people in United States
Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations
Where
Durham
Age
65 years and over
People
45
Run by
Duke University
See details and how to joinNCT07275359
No phaseEnrolling by invitation
Firefighter's Longitudinal Airway and Respiratory Exposome/Multiome Study (FLARES)
Where
Bethesda
Age
18 years to 65 years
People
350
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT07867184
Phase 2Taking people
To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment
Where
Altamonte Springs, Aurora, Bradenton, Burke, Clermont, Columbus, Crystal River, Cypress, DuBois, Encino, Hannibal, Indianapolis, Kansas City, Leesburg, Maplewood, McKinney, Miami, Northridge, Orange City, Philadelphia, Phoenix, Raleigh, Rincon, Rock Hill, Shelby, Shreveport, Tomball, Topeka, Virginia Beach
Age
40 years to 85 years
People
600 worldwide
Run by
Expedition Therapeutics, Inc
See details and how to joinNCT07684820
No phaseTaking people
Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD
Where
San Francisco
Age
40 years to 90 years
People
387
Run by
University of California, San Francisco
See details and how to joinNCT05572632
Phase 4Taking people
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
Where
Birmingham
Age
19 years and over
People
30
Run by
University of Alabama at Birmingham
See details and how to joinNCT07135427
Phase 3Taking people
A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)
Where
Birmingham, Charleston, Cleveland, Dallas, Gainesville, Los Angelas, Miami, Phoenix, Rochester, Scottsdale
Age
18 years to 80 years
People
40 worldwide
Run by
Grifols Therapeutics LLC
See details and how to joinNCT07555483 · EU 2025-522792-29-00
No phaseTaking people
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Where
New York
Age
18 years and over
People
2,000
Run by
Weill Medical College of Cornell University
See details and how to joinNCT01776398
Phase 2Taking people
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Where
Baltimore, Birmingham, Boerne, Brandon, Burlington, Camp Hill, Canoga Park, Cape Coral, Chattanooga, Chesterfield, Clearwater, Cleveland, Colchester, Dallas, Denison, DuBois, El Paso, Farmington Hills, Franklin, Garden City, Glendale, Grand Rapids, Hannibal, Houston, Jacksonville, Johnson City, Kingwood, Lake City, Lakewood, La Mesa, Lancaster, Lewisville, Lexington, Los Angeles, Madison, Mansfield, Marion, McKinney, Medford, Miami, Miami Lakes, Missoula, Morgantown, Mount Kisco, Naples, New Bern, Newport Beach, Norco, Norfolk, Ocala, Oklahoma City, Ormond Beach, Pearland, Philadelphia, Phoenix, Pittsburgh, Plantation, Portland, Rapid City, Sarasota, Scottdale, Smithfield, Spartanburg, St Louis, Suwanee, Tamarac, Tampa, Tulsa, Tustin, West Des Moines, Williamsburg, Winter Park, Zachary
Age
40 years and over
People
987 worldwide
Run by
AstraZeneca
See details and how to joinNCT07082738
Phase 3Taking people
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
Where
Adairsville, Allen Park, Austin, Baltimore, Beckley, Birmingham, Boulder, Brandon, Brighton, Buffalo, Champaign, Chattanooga, Columbia, Dallas, DeLand, Denison, Detroit, El Paso, Farmington Hills, Greenacres City, Greenville, Hamilton, Hammond, Hannibal, Hendersonville, Hialeah, Houston, Jacksonville, Lakewood, Las Vegas, Lehigh Acres, Long Beach, Los Angeles, Loxahatchee Groves, Media, Miami, Missouri City, Mobile, Newark, New Bedford, New Windsor, Normal, Northridge, Orlando, Pensacola, Peoria, Plantation, Portland, San Diego, Sarasota, Shreveport, Statesville, St Louis, St. Petersburg, Sugar Land, Tampa, Toledo, Tucson, Tulsa, Washington D.C., Winston-Salem, Wylie
Age
40 years to 80 years
People
942 worldwide
Run by
Sanofi
See details and how to joinNCT07190222 · EU 2024-518213-25-00
Phase 2Taking people
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
Where
Charlotte, DuBois, Jacksonville, Los Angeles, McKinney, Medford, Miami Lakes, North Dartmouth, Waxahachie
Age
40 years to 80 years
People
105 worldwide
Run by
Windward Bio
See details and how to joinNCT07646587
Phase 2/3Taking people
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Where
Bangor, Birmingham, Boerne, Carrollton, Chappaqua, Columbia, Cypress, Dallas, Dearborn, Dothan, DuBois, East Point, Fall River, Flint, Flushing, Franklin, Gaffney, Greenacres City, Hammond, Henderson, Hendersonville, Houston, Kansas City, Kissimmee, La Palma, Loxahatchee Groves, Merrillville, Miami, Mobile, Mount Kisco, Newport Beach, North Dartmouth, Northridge, Ocala, Philadelphia, Phoenix, Phoenixville, Rapid City, Rincon, Rock Hill, San Diego, Sherman, Southfield, Spartanburg, St Louis, St. Petersburg, Tampa, Toledo, Troy, Tulsa, Winston-Salem, Winter Park, Zachary
Age
35 years to 80 years
People
1,156 worldwide
Run by
Pfizer
See details and how to joinNCT07363694 · EU 2024-518587-12-00
Phase 2Taking people
Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
Where
Anderson, Binghamton, Bradenton, Brooklyn, Columbus, Dallas, Dearborn, DuBois, East Point, Edmond, Hamilton, Inglewood, Kings Mountain, Kingwood, Las Vegas, Lewisville, Lexington, Lutherville, Medford, Miami Lakes, Milford, Mobile, Naperville, Newport Beach, Pittsburgh, Rock Hill, San Diego, Sayre, Snellville, Spartanburg, Tamarac, Tempe, Tomball, Troy, Union, Valparaiso
Age
40 years to 85 years
People
180 worldwide
Run by
Altesa Biosciences, Inc.
See details and how to joinNCT07610395
Phase 3Enrolling by invitation
A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants With Chronic Obstructive Pulmonary Disease (COPD)
Where
Boynton Beach, Miami Lakes, Newport Beach, Tampa
Age
40 years to 80 years
People
1,508 worldwide
Run by
Sanofi
See details and how to joinNCT07793409
Phase 4Taking people
A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.
Where
Baltimore, Beaumont, Birmingham, Boston, Charlotte, Cordele, DuBois, Kansas City, Miami, Winston-Salem
Age
40 years to 85 years
People
218 worldwide
Run by
Sanofi
See details and how to joinNCT07053423