Studies memory and thinking changes in people with dementia and related conditions
Follows adults aged 50 to 90 with dementia, memory problems or Parkinson's disease over time.
Plain-language title generated from the registry record
Registry title: Comprehensive Assessment of Neurodegeneration and Dementia
Key facts
- Where
- Calgary, Edmonton, Halifax, Hamilton, London, Montreal, Ottawa, Peterborough, Québec, Sherbrooke, Toronto, Vancouver, Victoria, and Waterloo, CanadaSee the 19 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50 to 90 with memory or thinking problems, or with Parkinson's disease, and for people with no thinking problems as a comparison group.
- Age
- 50 to 90 years
- Sex
- All sexes
- Disease stage
- People with subjective or mild cognitive impairment, vascular mild cognitive impairment, Parkinson's disease (with or without mild cognitive impairment), or no cognitive impairment.
Main reasons for not taking part
- Other significant chronic brain disease, such as multiple sclerosis or malignant tumors
- Ongoing alcohol or drug abuse that may interfere with the study
- Symptomatic stroke within the previous year
- Cannot have an MRI scan
- No study partner to give extra information
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 90 years old?
Source: NCT03402919, who can take part
Where in Canada
- University Of CalgaryCalgary, CanadaContact: Eric E Smith, MDTaking people
- University of Alberta HospitalEdmonton, CanadaContact: Richard Camicioli, MDTaking people
- Veteran's Memorial BuildingHalifax, CanadaContact: Maia von Maltzahn, MDTaking people
- Hamilton General HospitalHamilton, CanadaContact: Demetrios Sahlas, MDTaking people
- Gait and Brain LabLondon, CanadaContact: Manuel Montero-Odasso, MDTaking people
- St. Joseph's Health Care LondonLondon, CanadaContact: Michael Borrie, MDTaking people
- Clinique de cognition Institut universitaire de gériatrie de MontréalMontreal, CanadaContact: Marie-Jeanne Kergoat, MDTaking people
- Jewish General Hospital/McGill Memory ClinicMontreal, CanadaContact: Susan Vaitekunas, MDTaking people
- Research Institute of the McGill University Health CentreMontreal, CanadaContact: Howard Chertkow, MDNo longer taking part
- Bruyère Research InstituteOttawa, CanadaContact: Howard Chertkow, MDNo longer taking part
- Kawartha CentrePeterborough, CanadaContact: Howard Chertkow, MDNo longer taking part
- Hôpital Enfant-JésusQuébec, CanadaContact: Louis Verret, MDTaking people
- Centre de recherche sur le vieillissement CIUSSS de l'Estrie-CHUSSherbrooke, CanadaContact: Howard Chertkow, MDNo longer taking part
- Baycrest Clinical UnitToronto, CanadaContact: Howard Chertkow, PhDTaking people
- Sunnybrook Health Sciences CentreToronto, CanadaContact: Howard Chertkow, MDNo longer taking part
- University Health Network Memory ClinicToronto, CanadaContact: Howard Chertkow, MDNo longer taking part
- Djavad Mowafaghian Centre for Brain HealthVancouver, CanadaContact: Robin Hsiung, MDTaking people
- Island HealthVictoria, CanadaContact: Alexandre Henri-Bhargava, MDNot yet recruiting
- University of WaterlooWaterloo, CanadaContact: Howard Chertkow, MDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- McGill University
- Trial code
- NCT03402919
- Record updated
- 20 January 2026
- Original description
This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits. Participants are/will be recruited at sites across Canada and will undergo assessments, neuroimaging, and biological sample collection.Read full original descriptionShow less
The Comprehensive Assessment of Neurodegeneration and Dementia Study
This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits. Participants are/will be recruited at sites across Canada and will undergo assessments, neuroimaging, and biological sample collection.
Inclusion: Has subjective or objective cognitive impairment; Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member); Sufficient proficiency in English or French to undertake self report and neuropsychological testing; Geographic accessibility to the study site; Must have a study partner who can participate as required in the protocol (provide corroborative information); Up to 12 years of education; Fits into one of the following groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment.
Exclusion: The presence of other significant known chronic brain disease such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, malignant tumors, Parkinson's disease (other than for the Parkinson's cohort), and other rarer brain illnesses; Ongoing alcohol or drug abuse which in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures; Symptomatic stroke within the previous year; Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure.