Alzheimer disease trials in Canada

In Canada 57 Also abroad 815

57 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseNot yet taking people in Canada
Veech Ketone Ester to Support Brain Energy in Mild Cognitive Impairment and Early Alzheimer's Disease
Where
London
Age
21 years and over
People
17
Run by
University of Pennsylvania
See details and how to joinNCT06767124
Phase 1/2Taking people
Trial of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's Disease or Primary Tauopathies
Where
East York, Montreal, Toronto
Age
18 years and over
People
160 worldwide
Run by
Arrowhead Pharmaceuticals
See details and how to joinNCT07221344
Phase 3Taking people
Nabilone for Agitation Blinded Intervention Trial
Where
Calgary, Hamilton, London, Ottawa, Toronto, Whitby
Age
55 years and over
People
112
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT04516057
Phase 3Taking people
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
Where
Hamilton, London, Montreal, Toronto, Whitby
Age
55 years to 90 years
People
426 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07011732 · EU 2025-520613-31-00
Phase 2/3Taking people
Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia
Where
North York, Peterborough, Whitby
Age
55 years to 90 years
People
300 worldwide
Run by
Exciva GmbH
See details and how to joinNCT07284472 · EU 2024-517388-22-00
Phase 2Taking people
A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease
Where
Montreal, Ottawa, Toronto
Age
55 years to 85 years
People
160 worldwide
Run by
Sanofi
See details and how to joinNCT07688213 · EU 2025-524581-14-00
Phase 3Taking people
A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease
Where
Kelowna, Montreal, Peterborough, Québec, Toronto
Age
55 years to 80 years
People
1,600 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07717411
No phaseTaking people
A Post Authorization Registry Study of Participants Treated With LEQEMBI
Where
Calgary, Edmonton, Gatineau, Greenfield Park, Kingston, London, Mississauga, Montreal, Ottawa, Peterborough, Québec, Toronto, Vancouver, Victoria
People
400
Run by
Eisai Limited
See details and how to joinNCT07762092
No phaseEnrolling by invitation
BioMIND Biospecimen Repository
Where
London
Age
18 years and over
People
1,000
Run by
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
See details and how to joinNCT07912736
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
Where
Greenfield Park, Halifax, Kelowna, Ottawa, Québec, Richmond, Toronto, Victoriaville
Age
60 years to 85 years
People
586 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06976216 · EU 2025-520746-30-00
No phaseNot yet taking people in Canada
Virtual Reality to Advance Dementia Care and Quality of Life
Where
London
Age
55 years and over
People
10
Run by
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
See details and how to joinNCT07893678
Phase 1Taking people
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
Where
Montreal, Toronto
Age
18 years and over
People
60 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT05231785 · EU 2023-508363-79-00
Phase 2Taking people
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Where
Montreal, Ottawa, Toronto
Age
50 years to 85 years
People
340 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07033494 · EU 2024-519190-19-00
No phaseNot yet taking people in Canada
Remote Digital Assessments for Cognitive Disorders
Where
Toronto
Age
50 years and over
People
60
Run by
Centre for Addiction and Mental Health
See details and how to joinNCT07883746
Phase 3Taking people
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
Where
Halifax, Kelowna, London, Montreal, Ottawa, Peterborough, Québec, Richmond, Toronto
Age
50 years to 90 years
People
80,000 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07177352
Phase 3Taking people
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
Where
Calgary, Hamilton, Montreal, Verdun, Whitby
Age
55 years to 90 years
People
1,000 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT05980949 · EU 2023-504151-27-00
Phase 3Taking people
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)
Where
Calgary, Hamilton, Montreal, Toronto, Verdun, Whitby
Age
55 years to 90 years
People
500 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT06126224 · EU 2023-504416-16-00
Phase 3Taking people
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
Where
Hamilton, London, Toronto, Whitby
Age
55 years to 90 years
People
650 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06937229 · EU 2024-519994-20-00
No phaseTaking people
Development of Eye-movement Based Biomarkers in Alzheimer's Disease
Where
Montreal, Ville-Marie
Age
18 years and over
People
250
Run by
McGill University
See details and how to joinNCT05176704
Phase 1Taking people
A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease
Where
Montreal, Ottawa, Toronto
Age
40 years to 80 years
People
50 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT07214727 · EU 2025-522582-30-00
No phaseTaking people
Dominantly Inherited Alzheimer Network (DIAN)
Where
Verdun
Age
18 years and over
People
700 worldwide
Run by
Washington University School of Medicine
See details and how to joinNCT00869817
Phase 1/2Taking people
Clinical Study of SNK01 in Participants With Moderate Alzheimer's Disease
Where
Ottawa
Age
40 years to 85 years
People
36 worldwide
Run by
NKGen Biotech, Inc.
See details and how to joinNCT06189963
Phase 2Taking people
A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis
Where
Brampton, Lévis, London, Toronto
Age
55 years to 90 years
People
300 worldwide
Run by
MapLight Therapeutics
See details and how to joinNCT06887192 · EU 2024-519820-26-00
No phaseEnrolling by invitation
Alzheimer's Disease Neuroimaging Initiative 4
Where
London, Toronto, Vancouver
Age
55 years to 90 years
People
1,500 worldwide
Run by
University of Southern California
See details and how to joinNCT05617014
No phaseTaking people
ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
Where
Toronto
People
200
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT04335994