Tests how leg vein stretching affects blood pressure when standing
Tests whether stretching leg veins raises blood pressure in adults.
Plain-language title generated from the registry record
Registry title: The Venous Distension Reflex and Orthostatic Hypertension
Key facts
- Where
- Hershey, United StatesSee the site
Where in United States
- Penn State Milton S. Hershey Medical CenterHershey, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Milton S. Hershey Medical Center
- Trial code
- NCT03496792
- Record updated
- 9 July 2026
- Original description
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).Read full original descriptionShow less
The Venous Distension Reflex and Orthostatic Hypertension
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
Inclusion: Are capable of giving informed consent; Are of any race or ethnicity; Are fluent in written and spoken English; Whose history and physical exam did not uncover any exclusion criteria; Are 18 years of age; For subjects with elevated standing BP; Systolic BP (SBP) during standing is at least 10 mmHg > the supine SBP; Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED; For normal subjects without elevated standing BP; The change in SBP by standing is within ± 5 mmHg from the supine SBP; Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP; Free of acute or chronic medical conditions.
Exclusion: Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension; Have orthostatic hypotension or a history of syncope; History of blood clots; Age < 18 years of age; Are a pregnant or nursing woman; Are a prisoner or institutionalized individual or unable to consent; Current smoker.