Tests intensive versus liberal phosphate targets in adults on dialysis for kidney failure
Compares two blood phosphate targets in adults with kidney failure receiving dialysis.
Plain-language title generated from the registry record
Registry title: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
Key facts
- Where
- Airdrie, Birkenhead, Birmingham, Bradford, Brighton, Bury St Edmunds, Cambridge, Canterbury, Cardiff, Carlisle, Carshalton, Cheltenham, Cosham, Coventry, Derby, Doncaster, Dorchester, Dudley, Exeter, Glasgow, Great Yarmouth, Hull, Inverness, Ipswich, Kilmarnock, Leicester, Liverpool, London, Manchester, Middlesbrough, Newcastle upon Tyne, Nottingham, Plymouth, Reading, Salford, Sheffield, Shrewsbury, Southend-on-Sea, Stevenage, Stoke-on-Trent, Sunderland, Wolverhampton, and York, United KingdomSee the 46 sites
Where in United Kingdom
- NHS LanarkshireAirdrie, United KingdomTaking people
- Wirral University Teaching Hospital NHS Foundation TrustBirkenhead, United KingdomTaking people
- University Hospital Birmingham NHS Foundation TrustBirmingham, United KingdomTaking people
- Bradford Teaching Hospital NHS Foundation TrustBradford, United KingdomTaking people
- University Hospitals Sussex NHS Foundation TrustBrighton, United KingdomTaking people
- West Suffolk HospitalBury St Edmunds, United KingdomTaking people
- Cambridge University Hospitals NHS Foundation TrustCambridge, United KingdomTaking people
- East Kent Hospitals University NHS Foundation TrustCanterbury, United KingdomTaking people
- Cardiff and Wales University Local Health BoardCardiff, United KingdomTaking people
- North Cumbria Integrated Care NHS Foundation TrustCarlisle, United KingdomTaking people
- Epsom and St Helier University Hospitals NHS TrustCarshalton, United KingdomTaking people
- Gloucestershire Hospital NHS Foundation TrustCheltenham, United KingdomTaking people
- Portsmouth Hospitals University NHS TrustCosham, United KingdomTaking people
- University Hospitals Coventry & WarwickshireCoventry, United KingdomTaking people
- University Hospitals of Derby and BurtonDerby, United KingdomTaking people
- Doncaster and Bassetlaw Teaching Hospitals NHS Foundation TrustDoncaster, United KingdomTaking people
- Dorset County Hospital NHS Foundation TrustDorchester, United KingdomTaking people
- The Dudley Group Nhs Foundation TrustDudley, United KingdomTaking people
- Royal Devon and Exeter NHS Foundation TrustExeter, United KingdomTaking people
- NHS Greater Glasgow and ClydeGlasgow, United KingdomTaking people
- James Paget University Hospitals NHS Foundation TrustGreat Yarmouth, United KingdomTaking people
- Hull University Teaching Hospital NHS TrustHull, United KingdomTaking people
- Nhs HighlandInverness, United KingdomTaking people
- Ipswich Hospital (East Suffolk & North Essex Foundation Trust)Ipswich, United KingdomTaking people
- NHS Ayrshire and ArranKilmarnock, United KingdomTaking people
- University Hospitals of Leicester NHS TrustLeicester, United KingdomTaking people
- Royal Liverpool University HospitalsLiverpool, United KingdomTaking people
- University Hospital AintreeLiverpool, United KingdomTaking people
- Guy's and St Thomas' NHS Foundation TrustLondon, United KingdomTaking people
- King's College Hospital NHS Foundation TrustLondon, United KingdomTaking people
- St. George's University Hospitals NHS Foundation TrustLondon, United KingdomTaking people
- Manchester University NHS Foundation TrustManchester, United KingdomTaking people
- South Tees Hospitals NHS Foundation TrustMiddlesbrough, United KingdomTaking people
- The Newcastle Upon Tyne Hospitals NHS Foundation TrustNewcastle upon Tyne, United KingdomTaking people
- Nottingham University Hospitals NHS TrustNottingham, United KingdomTaking people
- University Hospitals Plymouth NHS TrustPlymouth, United KingdomTaking people
- Royal Berkshire NHS Foundation TrustReading, United KingdomTaking people
- Salford Royal NHS Foundation TrustSalford, United KingdomTaking people
- Sheffield Teaching Hospitals NHS Foundation TrustSheffield, United KingdomTaking people
- Shrewsbury and Telford Hospital NHS TrustShrewsbury, United KingdomTaking people
- Mid and South Essex NHS Foundation TrustSouthend-on-Sea, United KingdomTaking people
- East and North Hertfordshire NHS TrustStevenage, United KingdomTaking people
- University Hospital of North Midlands NHS TrustStoke-on-Trent, United KingdomTaking people
- South Tyneside and Sunderland NHS Foundation TrustSunderland, United KingdomTaking people
- The Royal Wolverhampton NHS TrustWolverhampton, United KingdomTaking people
- York and Scarborough Teaching Hospitals NHS Foundation TrustYork, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The University of Queensland
- Trial code
- NCT03573089
- Record updated
- 26 August 2026
- Original description
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.Read full original descriptionShow less
An Investigator-initiated, International, Multi-centre, Prospective, Randomized, Open-label, Parallel-group, Superiority, and Pragmatic Large Simple Trial (LST) to Determine Whether the Currently Recommended Strategy of Intensive Reduction of Serum Phosphate Concentration Towards the Normal Level Results in Significant Patient-centred Benefits in End-stage Kidney Disease (ESKD) Patients Receiving Dialysis.
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.
Inclusion: Age ≥45 years, or Age ≥18 years with diabetes,; ESKD on haemodialysis or peritoneal dialysis, for at least 3 months,; Currently prescribed at least one phosphate-lowering medication at any dose; Able to provide informed consent.
Exclusion: Elective kidney transplantation scheduled,; Concomitant major illness / comorbidity that may result in death in the next 6 months in the view of the treating physician,; Participation in an interventional study that is likely to affect serum phosphate concentration.