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Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders

Key facts

Who runs it
Yale University
Where
New Haven, United StatesSee the site
Trial code
Status
Completed
People taking part
214 people enrolled
Started
24 Aug 2018
Ended
31 Mar 2024
Type of study
Interventional, 3 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Supportive Parenting for Anxious Childhood Emotions
  • Parent Educational Support
  • Cognitive-Behavioral Therapy
Record updated
22 April 2026

Who can take part

Age
6 years to 12 years
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • Prepubertal
  • Clinical diagnosis of primary anxiety disorder
  • Must not have another mental illness more impairing than the most impairing anxiety disorder
  • IQ of at least 80

Who cannot take part

  • Contraindications for MRI scanning (e.g., metal implants, pacemakers, braces, claustrophobia, pregnancy, weight > 250 pounds)
  • Neurological disorders (including seizures)
  • Organic mental disorders, psychotic disorders, or pervasive developmental disorders
  • History of neurological illness or head injury with loss of consciousness > 5 minutes
  • High likelihood of hurting themselves or others
  • Current psychosocial or psychopharmacological treatment
  • Vision or physical disability that interferes with seeing stimuli presented briefly on computer screen and/or clicking a mouse button rapidly and repeatedly

Where in United States

  • Yale University Child Study CenterNew Haven, United States

About the trial

What the trial wants to find out

This study aims to investigate whether a parent-based treatment for childhood anxiety disorders engages child brain circuitry implicated in children's reliance on parents to reduce anxiety (R61), and whether change in child brain circuitry is associated with reduction in child anxiety (R33).

The 3 groups in the trial

  • Supportive Parenting for Anxious Childhood Emotions (SPACE)Treatment being tested

    Parent-based treatment for childhood anxiety disorders, 12 sessions with parents.

    Treatment: Supportive Parenting for Anxious Childhood Emotions

  • Parent Educational Support (PES)Existing treatment, for comparison

    Parent Educational Support: 12 sessions with parents

    Treatment: Parent Educational Support

  • Cognitive Behavioral Therapy (CBT)Existing treatment, for comparison

    Cognitive-Behavioral Therapy: 12 sessions with child

    Treatment: Cognitive-Behavioral Therapy

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Record updated
22 April 2026