Enrolling by invitationNo phase
Muscle Stimulation During DISE
Key facts
- Who runs it
- Vanderbilt University Medical Center
- Where
- Nashvile, United StatesSee the site
- Trial code
- Status
- Enrolling by invitation
- People taking part
- 60 people, planned
- Started
- 26 Jul 2018
- Expected to end
- Dec 2028
- Type of study
- Interventional
- Treatments tested
- Grass S88 Muscle Stimulator
- Record updated
- 21 August 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Adult patient (≥18 years old)
- A diagnosis of obstructive sleep apnea as determined by polysomnogram with an apnea-hypopnea index of ≥ 5.0/hr
- Intolerant of CPAP therapy due to physical or psychosocial limitations as determined by clinical history
- Scheduled to undergo DISE as part of routine clinical assessment for further evaluation of pharyngeal anatomy
Who cannot take part
- Unable to consent for research due to a pre-existing neurologic condition as determined by PI
- A history of egg allergy as determined by history or self-reports
- Cardiopulmonary or other medical conditions precluding safe propofol sedation as determined by pre-operative anesthesia evaluation
- History of palatal or pharyngeal airway surgery including tonsillectomy as determined by clinical history and exam
- History of radiation treatment to the head or neck as determined by history and/or physical exam
- Unable to consent for research due to language barriers
- Currently pregnant as determined by patient report or pre-operative anesthesia evaluation
Where in United States
- Vanderbilt University Medical CenterNashvile, United StatesNo longer taking part
About the trial
What the trial wants to find out
Drug-induced sleep endoscopy (DISE) is a widely used tool for assessing collapse patterns of the upper airway anatomy during sleep. Hypoglossal nerve stimulation therapy for obstructive sleep apnea suffers from variable response at the level of the soft palate. We propose a study examining the physiologic effect of palatoglossus and genioglossus muscle stimulation during DISE.
The group in the trial
- Muscle stimulationTreatment being tested
Consented participants who meet eligibility will have a drug induced sleep endoscopy (DISE) and the Grass S88 muscle stimulator.
Treatment: Grass S88 Muscle Stimulator
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effect of Palatoglossus and Genioglossus Stimulation During Drug-Induced Sleep Endoscopy
- Record updated
- 21 August 2026