Measuring Light Sensitivity Using Devices in Adults With Headache or Brain Injury
Tests devices that measure eye and facial responses to light in adults with light sensitivity.
Plain-language title generated from the registry record
Registry title: Objectively Diagnose and Monitor Treatment of Light Sensitivity
Key facts
- Where
- Iowa City, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT03694626, who can take part
Where in United States
- University of Iowa Health CareIowa City, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Randy Kardon
- Trial code
- NCT03694626
- Record updated
- 8 September 2026
- Original description
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.Read full original descriptionShow less
Use of Facial Feature to Objectively Diagnose and Monitor Treatment of Light Sensitivity
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.
Inclusion: Healthy individuals with normal eye exam in the previous year; Age 18-80; Age 18-80; Traumatic Brain Injury (TBI).
Exclusion: Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics; Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics - Must not be light sensitive or get migraine headaches (use headache criteria from Ana if we are including headaches); Patients with photosensitivity from non-TBI causes Inclusion Criteria; Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics; TBI patients with photosensitivity Inclusion Criteria; History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury/surgery; History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled; Photosensitivity: determined by patient reporting symptoms and there may or may not be an identified cause associated with their light sensitivity (i.e. history of uveitis, childhood exotropia, meningitis, radiation, tumor); History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury/surgery; History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled; Age 18-80; Age 18-80; Must not be light sensitive or get migraine headaches; TBI patients without photosensitivity or headache:; Photosensitivity: determined by patient reporting symptoms and cause associated with their light sensitivity is post TBI; TBI.
Healthy Control subjects:.