Studies Recovery From Muscle Weakness After Severe Heart or Lung Failure
Observes patients with severe heart or lung failure to study factors affecting weakness recovery.
Key facts
- Who runs it
- Barts & The London NHS Trust
- Where
- London, United KingdomSee the site
- Trial code
- Registry title
- Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 9 Apr 2019
- Planned end
- 26 Sept 2026
- Type of study
- Observational
- Record updated
- 7 January 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with severe heart and lung failure who need ECMO (a machine that supports the heart and lungs). It studies how they recover from weakness gained in intensive care.
- Age
- Above 18 years
- Sex
- All sexes can join
- Disease stage
- Severe heart and lung failure that needs ECMO
Main reasons for not taking part
- Previous stroke
- Neuromuscular disease
- Cancer (malignancy)
- Children (paediatric patients)
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Above the age of 18
- Adults with severe cardio-respiratory failure requiring ECMO
- Adults who have had personal and professional consultees agree to enrol them in the trial
Who cannot take part
- Previous Stroke
- Neuromuscular disease
- Malignancy
- Underlying neuromuscular disease
- paediatrics
Where in United Kingdom
- St. Bartholomew's Hospital, Barts NHS TrustLondon, United KingdomContact: Griffiths, Mark Griffiths, FRRCP, PhDTaking people
About the trial
What the trial wants to find out
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO). Additionally, to discover the effects of ICUAW on physical function and health-related quality of life (HRQoL) after critical illness. CLEVERER is a clinical observational pilot study.
The group in the trial
- ICUAW ECMO group
The physical and psychological effects of ICUAW on patients receiving extracorporeal membrane oxygenation for severe cardiorespiratory failure will be observed. Physical function and HRQoL will be analysed and correlated with RFcsa. Additionally, biological markers will be used to understand molecular and genomic profiles.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Prospective Observational Study Regarding the Determinants of Functional Disability and Quality of Life in Patients Recovering From Severe Acute Cardiac or Respiratory Failure Considered for Mechanical Cardiorespiratory Support (CLEVERER)
- Plain-language title
- Studies Recovery From Muscle Weakness After Severe Heart or Lung FailureGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 7 January 2026