Laser-guided corneal collagen cross-linking for keratoconus, using eye scans to set the laser
Tests scan-guided laser settings during cross-linking in adults with keratoconus.
Key facts
- Who runs it
- Oregon Health and Science University
- Where
- Portland, United StatesSee the site
- Trial code
- Registry title
- Collagen Cross-linking in Keratoconus
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 20 Jun 2018
- Expected to end
- Dec 2027
- Type of study
- Interventional
- Treatments tested
- Laser Custom Corneal Collagen Cross-Linking
- Record updated
- 9 September 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with keratoconus, an eye condition where the clear front of the eye (cornea) thins and bulges. They will have a laser procedure that strengthens the cornea, guided by OCT eye scans.
- Age
- 18 Years and older
- Sex
- All sexes can join
- Disease stage
- Keratoconus with a thinnest cornea thickness of at least 410 microns
Main reasons for not taking part
- Unable to keep the eye still for OCT scans
- Unable to attend the study visits or give consent
- Other eye diseases, such as retinal disease or glaucoma, that may limit vision after surgery
- Advanced (mature) cataract that limits vision to worse than 20/40
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Diagnosis of keratoconus
- Minimum corneal thickness of 410 microns
Who cannot take part
- Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery
- Inability to maintain fixation for OCT imaging
- Inability to commit to required study visits
- Inability to give informed consent
- Mature cataracts if found to limit visual potential to worse than 20/40
Where in United States
- Oregon Health Science UniversityPortland, United StatesContact: Denzil Romfh, ODTaking people
About the trial
What the trial wants to find out
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.
The group in the trial
- SurgeryTreatment being tested
OCT-guided custom laser CXL
Treatment: Laser Custom Corneal Collagen Cross-Linking
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Clinical Trial of Laser Custom Corneal Collagen Cross-Linking in Keratoconus
- Plain-language title
- Laser-guided corneal collagen cross-linking for keratoconus, using eye scans to set the laserGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 15 November 2026.
- Record updated
- 9 September 2025