Pain Relief Study After Prophylactic Femur Nailing in Cancer Patients
Compares ketorolac plus opioids against opioids alone for pain after femur nailing.
Plain-language title generated from the registry record
Registry title: Post-Op Pain Control for Prophylactic Intramedullary Nailing.
Key facts
- Where
- St Louis, United StatesSee the site
- Phase
- Phase 3
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a bone lesion in the thigh bone who plan to have a preventive metal rod placed in one femur. It compares pain control with and without ketorolac added to opioids.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- A bone lesion in the shaft or neck of the femur, with no fracture at the moment, and a plan for a preventive rod in one femur.
- Earlier treatment
- People using probenecid or pentoxifylline cannot join. People on a chemotherapy plan that rules out NSAIDs cannot join. People who need blood thinners or anti-platelet treatment during the study cannot join.
Main reasons for not taking part
- A fracture of the bone at the same time
- Advanced kidney problems (eGFR<30mL/min)
- A history of stomach ulcer with bleeding or hospital stay
- Allergy to NSAIDs, aspirin or acetaminophen with anaphylaxis, or aspirin-induced asthma
- Known opioid dependence, abuse or addiction, or pregnancy
Read by machine on 9 November 2026.
Where in United States
- Saint Louis UniversitySt Louis, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- St. Louis University
- Trial code
- NCT03823534
- Record updated
- 22 April 2026
- Original description
Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a unique subset of patients that undergo prophylactic placement of intramedullary femoral nails. Because no fracture is present, these patients do not rely on inflammatory healing factors, allowing for post-op NSAID use. This study sets out to determine the effect of post-op toradol use in addition to opioids compared to solely opioids in patients undergoing prophylactic nailing of the femur.Read full original descriptionShow less
Post-Op Pain Control for Prophylactic Intramedullary Nailing.
Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a unique subset of patients that undergo prophylactic placement of intramedullary femoral nails. Because no fracture is present, these patients do not rely on inflammatory healing factors, allowing for post-op NSAID use. This study sets out to determine the effect of post-op toradol use in addition to opioids compared to solely opioids in patients undergoing prophylactic nailing of the femur.
Inclusion: Femoral Shaft or Neck bone lesion; 18 years old or greater; Plan to undergo prophylactic intramedullary nailing of one femur.
Exclusion: Concurrent pathologic fracture; Concurrent chemotherapy regimen that prevents NSAID use; Current use of the medication probenecid; Current use of the medication Pentoxifylline; History of Peptic Ulcer Disease with bleeding or requiring hospitalization; History of NSAID or aspirin allergy; History of liver disease that precludes use of toradol; History of heart failure or cardiovascular disease that precludes toradol usage; History of narcotic allergy resulting in anaphylaxis; Patients with acetaminophen allergies resulting in anaphylaxis; History of aspirin induced asthma; Known history of opioid dependence, abuse, or addiction; History of advanced renal impairment (eGFR<30mL/min); Patients with coagulation disorders or those who require concomitant use of anticoagulant or anti- platelet therapy during the treatment phase of the study; Pregnancy; Bilateral IMN of the femurs.