Predicting Who Benefits From Gastric Bypass Surgery for Type 2 Diabetes
Studies adults with type 2 diabetes and obesity after gastric bypass surgery.
Plain-language title generated from the registry record
Registry title: Who Will Benefit From Bariatric Surgery for Diabetes?
Key facts
- Where
- London, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT03842475, who can take part
Where in United Kingdom
- Imperial College Healthcare NHS TrustLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Imperial College London
- Trial code
- NCT03842475
- Record updated
- 19 April 2023
- Original description
A study investigating the influence of fat distribution, genetic susceptibility markers for type 2 diabetes (T2DM) and fat distribution, epigenetic and transcriptomic changes and gut hormone responses to a mixed meal on diabetes remission following bariatric surgery.Read full original descriptionShow less
Who Will Benefit From Bariatric Surgery for Diabetes? Using Fat Distribution Measurement, Gut Hormone Profiles and Genetic Data to Predict Diabetes Remission
A study investigating the influence of fat distribution, genetic susceptibility markers for type 2 diabetes (T2DM) and fat distribution, epigenetic and transcriptomic changes and gut hormone responses to a mixed meal on diabetes remission following bariatric surgery.
Inclusion: Males and females planning to undergo RYGB; 18-80 years; Type 2 diabetes mellitus or prediabetes; Stable weight for at least 3 months; Obese (BMI ≥30kg/m2); Eligible for surgery on the National Health Service (NHS) under The National Institute for Health and Care Excellence (NICE) 2014 criteria; Aged 18-80 years; Male or female; Body mass index 19 - 25 kg/m2; Stable weight for at least three months.
Exclusion: Type 1 diabetes; Secondary diabetes or absence of β-cell function; Unable to undergo DEXA, cirrhosis, ascites, or other condition that may modify body fat composition e.g. underlying malignancy; History of any medical, or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study; Abnormal glucose tolerance and fasting glucose; Current pregnancy; Inability to give informed consent; Low fasting C-peptide; Current smoker; Participation in another (interventional) trial within the last 3 months; Unable to understand English; Healthy volunteers; Without access at home to a telephone, or other factor likely to interfere with ability to participate reliably in the study; Pregnancy or breastfeeding; Unable to maintain adequate contraception for the duration of the study; Donated blood during the preceding 3 months or intention to do so before the end of the study; Current smoker; Participation in another trial within the last 3 months; Unable to understand English.
Bariatric surgery group.