Low-dose radiotherapy for painful bone spread in multiple myeloma
Tests low-dose radiation for bone pain in adults with myeloma spread to bone.
Plain-language title generated from the registry record
Registry title: Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma
Key facts
- Where
- Atlanta, Boston, Duarte, Los Angeles, Minneapolis, New York, and Philadelphia, United StatesSee the 9 sites
Where in United States
- Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesTaking people
- Dana-Farber Cancer InstituteBoston, United StatesTaking people
- City of HopeDuarte, United StatesTaking people
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Los Angeles General Medical CenterLos Angeles, United StatesTaking people
- USC / Norris Comprehensive Cancer CenterLos Angeles, United StatesTaking people
- University of Minnesota/Masonic Cancer CenterMinneapolis, United StatesTaking people
- Icahn School of Medicine at Mount SinaiNew York, United StatesTaking people
- University of Pennsylvania/Abramson Cancer CenterPhiladelphia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Southern California
- Trial code
- NCT03858205
- Record updated
- 5 June 2026
- Original description
This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more convenient for patients and their families, may not interfere as much with the timing of chemotherapy, and may have less chance for short term or long-term side effects from the radiation.Read full original descriptionShow less
Phase II Multi-Institutional Study of Low-Dose (2Gy) Palliative Radiotherapy in the Treatment of Symptomatic Bone Metastases From Multiple Myeloma
This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more convenient for patients and their families, may not interfere as much with the timing of chemotherapy, and may have less chance for short term or long-term side effects from the radiation.
Inclusion: Histologic diagnosis of multiple myeloma; Painful bone metastasis (index lesion) that has a radiographic correlate; Patient may have had any number of prior chemotherapy/immunotherapy regimens (changes to systemic therapy or use of bisphosphonates for 4 weeks before and after RT are allowed, but recording of these changes must be made so it can be accounted for); Eastern Cooperative Oncology Group (ECOG) 0-2; Brief Pain Inventory (BPI) score >= 2; Ability to understand and the willingness to sign a written informed consent.
Exclusion: Patients will be ineligible if the index lesion has received prior radiation therapy or prior palliative surgery. Patients may have received prior palliative or primary radiotherapy or surgery to other parts of the body, as long as the index lesion was not in the prior radiation fields and has not received prior palliative surgery; Patients will also be ineligible if there is pathologic fracture or impending fracture at the site of the index lesion or planned surgical fixation of the bone at the index lesion; Patients with clinical or radiographic evidence of spinal cord or cauda equina compression/effacement from the index lesion, and/or with index lesions located at the skull base or orbital lesions; Patients must not be pregnant.