Tracks pregnancies in women with multiple sclerosis and their children
Follows women with multiple sclerosis through pregnancy and their children afterwards.
Plain-language title generated from the registry record
Registry title: French Registry for Monitoring Pregnancies for Multiple Sclerosis
Key facts
- Where
- Amiens, Annecy, Avignon, Besançon, Bordeaux, Brive-la-Gaillarde, Bron, Caen, Chambéry, Clermont-Ferrand, Créteil, Dijon, Épinal, Garches, Gonesse, Grenoble, Le Chesnay, Lille, Limoges, Lyon, Marseille, Montpellier, Mornant, Nancy, Nice, Nîmes, Paris, Poissy, Poitiers, Pontoise, Rennes, Rouen, Saint-Denis, Saint-Herblain, Saint-Lô, Saint-Priest-en-Jarez, Strasbourg, Suresnes, Toulouse, Tours, and Villeurbanne, FranceSee the 47 sites
Where in France
- CHU D'amiensAmiens, FranceTaking people
- Centre Hospitalier Annecy GenevoisAnnecy, FranceTaking people
- Centre Hospitalier d'AvignonAvignon, FranceTaking people
- Hopital Jean MinjozBesançon, FranceTaking people
- Hopital PellegrinBordeaux, FranceTaking people
- Hôpital de BriveBrive-la-Gaillarde, FranceTaking people
- Hôpital Neurologique Pierre WertheimerBron, FranceTaking people
- Hôpital Côte De NacreCaen, FranceTaking people
- Centre Hospitalier Métropole SavoieChambéry, FranceTaking people
- Hopital Gabriel MontpiedClermont-Ferrand, FranceTaking people
- Hopital Henri MondorCréteil, FranceTaking people
- Hopital Du BocageDijon, FranceTaking people
- Ch EpinalÉpinal, FranceTaking people
- Hôpital Raymond-PoincaréGarches, FranceTaking people
- Centre hospitalier Joséphine Baker GonesseGonesse, FranceTaking people
- CHU de GrenobleGrenoble, FranceTaking people
- Centre Hospitalier de Versailles Hôpital Andre MignotLe Chesnay, FranceTaking people
- CHRU de LilleLille, FranceTaking people
- Hôpital St Vincent de PaulLille, FranceTaking people
- Hopital DupuytrenLimoges, FranceTaking people
- Cabinet médical Dr C. CORNUT-CHAUVINCLyon, FranceTaking people
- Cabinet médical Dr Philippe NEUSCHWANDERLyon, FranceTaking people
- Centre Hospitalier Saint Joseph Saint LucLyon, FranceTaking people
- Hopital Timone AdultesMarseille, FranceTaking people
- Hôpital Gui de ChauliacMontpellier, FranceTaking people
- Cabinet médical Dr L. GUILLOTONMornant, FranceTaking people
- Hôpital Central,Nancy, FranceTaking people
- Hopital PASTEURNice, FranceTaking people
- Hopital CaremeauNîmes, FranceTaking people
- Fondation RotschildParis, FranceTaking people
- Hôpital national des Quinze-Vingt.Paris, FranceTaking people
- Hôpital Paris Saint JosephParis, FranceTaking people
- Hopital Pitie-SalpetriereParis, FranceTaking people
- CHI Poissy-Saint-Germain en LayePoissy, FranceTaking people
- Chr La MiletriePoitiers, FranceTaking people
- Hopital Rene DubosPontoise, FranceTaking people
- Hôpital PontchaillouRennes, FranceTaking people
- Hôpital Charles NicolleRouen, FranceTaking people
- Centre Hospitalier de Saint-DenisSaint-Denis, FranceTaking people
- Hopital G. Et R. LaennecSaint-Herblain, FranceTaking people
- Centre Hospitalier MémorialSaint-Lô, FranceTaking people
- Hopital NordSaint-Priest-en-Jarez, FranceTaking people
- Hopital HautepierreStrasbourg, FranceTaking people
- Hopital FochSuresnes, FranceTaking people
- Hopital PurpanToulouse, FranceTaking people
- CHRU de Tours- Hopital BretonneauTours, FranceTaking people
- Médipôle Lyon-VilleurbanneVilleurbanne, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospices Civils de Lyon
- Trial code
- NCT03900221
- Record updated
- 5 January 2026
- Original description
The influence of pregnancy on the course of multiple sclerosis (MS) has long been a controversial topic. After the publication of the first large prospective study of pregnancy and MS in 1998, counselling of women with MS has radically changed and many patients have been able to fulfill their desire of motherhood. However, there are still some challenges for the neurologist, who has to face old unanswered questions or new issues, regarding the use of disease modifying drugs (DMDs) in this period of life, effects on the short and long term outcome of the mother (in terms of relapses and disability) and the child, role of breast-feeding and locoregional analgesia.Read full original descriptionShow less
French Registry for Monitoring Pregnancies and Children of Women With Multiple Sclerosis Within The Observatoire Français de la Sclérose en Plaque (OFSEP) Cohort
The influence of pregnancy on the course of multiple sclerosis (MS) has long been a controversial topic. After the publication of the first large prospective study of pregnancy and MS in 1998, counselling of women with MS has radically changed and many patients have been able to fulfill their desire of motherhood. However, there are still some challenges for the neurologist, who has to face old unanswered questions or new issues, regarding the use of disease modifying drugs (DMDs) in this period of life, effects on the short and long term outcome of the mother (in terms of relapses and disability) and the child, role of breast-feeding and locoregional analgesia.
To set up a national prospective pregnancy registry for patients with MS, nested within the Observatoire Français de la Sclérose en Plaque (OFSEP) cohort, owing to a better knowledge of interactions between MS and pregnancy-related issues (pregnancy itself, locoregional analgesia, breastfeeding, impact of using or stopping DMDs on women/children…)
Inclusion: All groups of patients eligible to participate to the Observatoire Français de la Sclérose en Plaque (OFSEP), including :; Definite Multiple sclerosis (MS) according to McDonald criteria; Whatever the clinical course (single attack MS, relapsing-remitting MS, secondary progressive MS, primary progressive MS); Radiologically Isolated Syndromes (RIS) (will be validated by the RIS expert group); Clinically Isolated Syndromes (CIS); Neuromyelitis optica (NMO) and NMO spectrum disorders (will be validated by the "Neuro-optico-myélite aiguë de Devic et des syndromes neurologiques apparentés" (NOMADMUS) expert group); No age limit (patients under the age of 18 might be included, provided informed consent is obtained from the parents); Ongoing pregnancy: there will be no limit in the gestational age at inclusion. Women can be included at any time before delivery, but the gestational age at inclusion will be recorded and introduced in the analyses whenever pertinent. However, neurologists and patients will be encouraged to start the study as soon as pregnancy is diagnosed; Able to give informed consent; Able to read and/or understand French.
Exclusion: None.