Taking people in United StatesPhase 3

Tests apixaban against aspirin in people with brain bleeding and atrial fibrillation

Compares apixaban with aspirin in adults with recent brain bleeding and atrial fibrillation.

Plain-language title generated from the registry record
Registry title: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Key facts

Where: Abington, Akron, Albany, Albuquerque, Allentown, Ann Arbor, Arlington Heights, Atlanta, Augusta, Aurora, Austin, Bangor, Birmingham, Boise, Boston, Brooklyn, Buffalo, Burlington, Carmichael, Castro Valley, Chandler, Chapel Hill, Charleston, Charlotte, Charlottesville, Chattanooga, Chicago, Cincinnati, Clearwater, Cleveland, Colton, Columbia, Columbus, Dallas, Danbury, Danville, Detroit, Downey, Durham, Edison, Elmhurst, Evanston, Falls Church, Flint, Fontana, Fort Lauderdale, Fresno, Fullerton, Grand Junction, Grand Rapids, Greensboro, Greenville, Hackensack, Hartford, Hershey, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kansas City, Knoxville, Lexington, Little Rock, Livingston, Long Beach, Los Alamitos, Los Angeles, Louisville, Manhasset, Marietta, Maywood, Memphis, Miami, Milwaukee, Minneapolis, Mobile, Modesto, Morgantown, Mount Clemens, Nashville, Neptune City, New Haven, New Orleans, New York, Newport Beach, Oklahoma City, Omaha, Orange, Palm Springs, Pasadena, Pensacola, Peoria, Philadelphia, Phoenix, Pittsburgh, Port Saint Lucie, Portland, Poughkeepsie, Providence, Redwood City, Richmond, Rochester, Rockford, Sacramento, Saint Cloud, Saint Louis Park, Saint Paul, Salt Lake City, San Antonio, San Francisco, Santa Barbara, Seattle, Sioux Falls, Springfield, St Louis, Stanford, Staten Island, Stony Brook, Summit, Syracuse, Tampa, The Bronx, Traverse City, Trenton, Tucson, Tulsa, Valhalla, Washington D.C., White Plains, Whittier, Wilmington, Winfield, Winston-Salem, Worcester, and Wyoming, United StatesSee the 185 sites
Phase: Phase 3

Where in United States

Jefferson Abington HospitalAbington, United StatesTaking people
Cleveland Clinic Akron GeneralAkron, United StatesTaking people
Albany Medical CenterAlbany, United StatesTaking people
University of New Mexico HospitalAlbuquerque, United StatesNo longer taking part
Lehigh Valley Hospital-Cedar CrestAllentown, United StatesNo longer taking part
University of Michigan University HospitalAnn Arbor, United StatesNo longer taking part
NCH Hospital, Arlington HeightsArlington Heights, United StatesTaking people
Emory University HospitalAtlanta, United StatesTaking people
Grady Memorial HospitalAtlanta, United StatesTaking people
Augusta University Medical CenterAugusta, United StatesTaking people
University of Colorado HospitalAurora, United StatesTaking people
St. David's Medical CenterAustin, United StatesNo longer taking part
Eastern Maine Medical CenterBangor, United StatesNo longer taking part
University of Alabama HospitalBirmingham, United StatesTaking people
Saint Alphonsus Regional Medical Center - BoiseBoise, United StatesTaking people
Beth Israel Deaconess Medical CenterBoston, United StatesTaking people
Boston Medical CenterBoston, United StatesTaking people
Massachusetts General HospitalBoston, United StatesTaking people
Tufts Medical CenterBoston, United StatesTaking people
Kings County Hospital CenterBrooklyn, United StatesTaking people
NYU Langone Hospital - BrooklynBrooklyn, United StatesTaking people
Maimonides Medical CenterBrooklyn, United StatesNo longer taking part
NewYork-Presbyterian Brooklyn Methodist HospitalBrooklyn, United StatesNo longer taking part
Buffalo General Medical CenterBuffalo, United StatesNo longer taking part
Lahey Hospital & Medical CenterBurlington, United StatesTaking people
The University of Vermont Medical CenterBurlington, United StatesTaking people
Mercy San Juan Medical CenterCarmichael, United StatesTaking people
Eden Medical Center, Castro ValleyCastro Valley, United StatesNo longer taking part
Chandler Regional Medical CenterChandler, United StatesNo longer taking part
University of North Carolina Medical CenterChapel Hill, United StatesTaking people
Medical University of South Carolina- University HospitalCharleston, United StatesTaking people
Presbyterian Medical CenterCharlotte, United StatesTaking people
Carolinas Medical CenterCharlotte, United StatesNo longer taking part
UVA Medical CenterCharlottesville, United StatesTaking people
Erlanger Health SystemChattanooga, United StatesNo longer taking part
Rush University Medical CenterChicago, United StatesTaking people
University of Chicago Medical CenterChicago, United StatesTaking people
University of Illinois HospitalChicago, United StatesTaking people
Good Samaritan HospitalCincinnati, United StatesTaking people
University of Cincinnati Medical CenterCincinnati, United StatesTaking people
Morton Plant HospitalClearwater, United StatesTaking people
Cleveland ClinicCleveland, United StatesTaking people
MetroHealth Medical CenterCleveland, United StatesTaking people
UH Cleveland Medical CenterCleveland, United StatesTaking people
Arrowhead Regional Medical CenterColton, United StatesTaking people
University of Missouri Health CareColumbia, United StatesTaking people
OSU Wexner Medical CenterColumbus, United StatesTaking people
Riverside Methodist HospitalColumbus, United StatesTaking people
UT Southwestern Medical CenterDallas, United StatesNo longer taking part
Danbury HospitalDanbury, United StatesNo longer taking part
Geisinger Medical CenterDanville, United StatesNo longer taking part
Henry Ford HospitalDetroit, United StatesNo longer taking part
Rancho Los Amigos National Rehabilitation CenterDowney, United StatesNo longer taking part
Duke University HospitalDurham, United StatesTaking people
JFK Medical CenterEdison, United StatesTaking people
NYC Health + Hospitals/ElmhurstElmhurst, United StatesTaking people
Evanston HospitalEvanston, United StatesTaking people
Inova Fairfax HospitalFalls Church, United StatesTaking people
McLaren-FlintFlint, United StatesNo longer taking part
Kaiser Permanente Fontana Medical CenterFontana, United StatesTaking people
Broward Health Medical CenterFort Lauderdale, United StatesTaking people
Community Regional Medical Center of FresnoFresno, United StatesTaking people
St. Jude Medical CenterFullerton, United StatesTaking people
St. Mary's Medical CenterGrand Junction, United StatesNo longer taking part
Trinity Health Saint Mary'sGrand Rapids, United StatesNo longer taking part
Moses H Cone Memorial HospitalGreensboro, United StatesTaking people
ECU Health Medical CenterGreenville, United StatesTaking people
Greenville Hospital SystemGreenville, United StatesTaking people
Hackensack University Medical CenterHackensack, United StatesTaking people
Hartford HospitalHartford, United StatesTaking people
Penn State Hershey Medical CenterHershey, United StatesTaking people
The Queen's Medical CenterHonolulu, United StatesTaking people
Houston Methodist HospitalHouston, United StatesTaking people
Memorial Hermann Texas Medical CenterHouston, United StatesTaking people
Baylor College of Medicine Medical CenterHouston, United StatesNo longer taking part
IU Health Methodist HospitalIndianapolis, United StatesTaking people
University of Iowa Medical CenterIowa City, United StatesTaking people
University of Mississippi Medical CenterJackson, United StatesNo longer taking part
UF Health JacksonvilleJacksonville, United StatesTaking people
Mayo ClinicJacksonville, United StatesNo longer taking part
University of Kansas HospitalKansas City, United StatesTaking people
Fort Sanders Regional Medical CenterKnoxville, United StatesTaking people
Baptist Health LexingtonLexington, United StatesTaking people
University of Kentucky HospitalLexington, United StatesTaking people
UAMS Medical CenterLittle Rock, United StatesNo longer taking part
Cooperman Barnabas Medical CenterLivingston, United StatesTaking people
Long Beach Memorial Medical CenterLong Beach, United StatesNo longer taking part
Los Alamitos Medical CenterLos Alamitos, United StatesTaking people
Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
Kaiser Permanente Los Angeles Medical CenterLos Angeles, United StatesTaking people
Ronald Reagan UCLA Medical CenterLos Angeles, United StatesTaking people
University of Louisville HospitalLouisville, United StatesTaking people
North Shore University HospitalManhasset, United StatesTaking people
Wellstar Kennestone HospitalMarietta, United StatesTaking people
Loyola University Medical CenterMaywood, United StatesTaking people
Methodist University HospitalMemphis, United StatesTaking people
Semmes Murphey Main CampusMemphis, United StatesTaking people
Jackson Memorial HospitalMiami, United StatesTaking people
Froedtert HospitalMilwaukee, United StatesNo longer taking part
Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
M Health Fairview University of Minnesota Medical CenterMinneapolis, United StatesTaking people
University of South Alabama University HospitalMobile, United StatesTaking people
Doctors Medical Center Modesto, Modesto, CAModesto, United StatesTaking people
J.W. Ruby Memorial HospitalMorgantown, United StatesTaking people
McLaren-MacombMount Clemens, United StatesNo longer taking part
Vanderbilt University HospitalNashville, United StatesTaking people
Jersey Shore University Medical CenterNeptune City, United StatesTaking people
Yale New Haven HospitalNew Haven, United StatesTaking people
Ochsner Medical Center - Main CampusNew Orleans, United StatesTaking people
Mount Sinai WestNew York, United StatesTaking people
NYP Columbia University Medical CenterNew York, United StatesTaking people
NYP/Weill Cornell Medical CenterNew York, United StatesTaking people
The Mount Sinai HospitalNew York, United StatesTaking people
Hoag Hospital Newport BeachNewport Beach, United StatesNo longer taking part
Mercy Hospital Oklahoma CityOklahoma City, United StatesTaking people
OU Medical CenterOklahoma City, United StatesTaking people
University of Nebraska Medical CenterOmaha, United StatesTaking people
UC Irvine Medical CenterOrange, United StatesTaking people
Desert Regional Medical CenterPalm Springs, United StatesTaking people
Huntington Memorial HospitalPasadena, United StatesNo longer taking part
Ascension Sacred Heart PensacolaPensacola, United StatesTaking people
OSF St Francis Medical CenterPeoria, United StatesTaking people
Hospital of the University of PennsylvaniaPhiladelphia, United StatesTaking people
Temple University HospitalPhiladelphia, United StatesTaking people
Thomas Jefferson University HospitalPhiladelphia, United StatesNo longer taking part
St. Joseph's Hospital and Medical CenterPhoenix, United StatesNo longer taking part
UPMC Presbyterian HospitalPittsburgh, United StatesTaking people
Cleveland Clinic Tradition HospitalPort Saint Lucie, United StatesTaking people
Maine Medical CenterPortland, United StatesTaking people
Oregon Health & Science University HospitalPortland, United StatesTaking people
Providence St. Vincent Medical CenterPortland, United StatesTaking people
Vassar Brothers Medical CenterPoughkeepsie, United StatesNo longer taking part
Rhode Island HospitalProvidence, United StatesNo longer taking part
Kaiser Permanente Redwood City Medical Center, Redwood City, CARedwood City, United StatesTaking people
Bon Secours St. Mary's HospitalRichmond, United StatesTaking people
VCU Medical CenterRichmond, United StatesNo longer taking part
Strong Memorial HospitalRochester, United StatesTaking people
Javon Bea Hospital - RiversideRockford, United StatesNo longer taking part
Kaiser Permanente Sacramento Medical CenterSacramento, United StatesTaking people
UC Davis Medical CenterSacramento, United StatesTaking people
St. Cloud HospitalSaint Cloud, United StatesTaking people
HealthPartners Methodist HospitalSaint Louis Park, United StatesNo longer taking part
Regions HospitalSaint Paul, United StatesNo longer taking part
United Hospital, St. PaulSaint Paul, United StatesNo longer taking part
University of Utah HealthcareSalt Lake City, United StatesTaking people
University of Texas Health Science Center San AntonioSan Antonio, United StatesTaking people
San Francisco General HospitalSan Francisco, United StatesTaking people
Santa Barbara Cottage HospitalSanta Barbara, United StatesTaking people
Harborview Medical CenterSeattle, United StatesTaking people
Swedish Medical Center - Cherry Hill CampusSeattle, United StatesNo longer taking part
Virginia Mason Medical CenterSeattle, United StatesNo longer taking part
Avera Research InstituteSioux Falls, United StatesTaking people
Baystate Medical CenterSpringfield, United StatesTaking people
Cox Medical Center SouthSpringfield, United StatesTaking people
Mercy Hospital SpringfieldSpringfield, United StatesTaking people
PeaceHealth Sacred Heart Medical Center - RiverBendSpringfield, United StatesTaking people
St. John's HospitalSpringfield, United StatesNo longer taking part
Barnes-Jewish HospitalSt Louis, United StatesTaking people
Mercy Hospital SouthSt Louis, United StatesTaking people
Mercy Hospital St. LouisSt Louis, United StatesTaking people
Stanford University Medical CenterStanford, United StatesTaking people
Staten Island University Hospital - North CampusStaten Island, United StatesNo longer taking part
Stony Brook University HospitalStony Brook, United StatesTaking people
Overlook Medical CenterSummit, United StatesTaking people
SUNY Upstate Medical UniversitySyracuse, United StatesTaking people
St. Joseph's HospitalTampa, United StatesTaking people
Tampa General HospitalTampa, United StatesTaking people
Montefiore Medical CenterThe Bronx, United StatesTaking people
Munson Medical CenterTraverse City, United StatesTaking people
Capital Health Regional Medical CenterTrenton, United StatesNo longer taking part
Banner University Medical CenterTucson, United StatesTaking people
Ascension St. John Medical CenterTulsa, United StatesTaking people
St. John Medical CenterTulsa, United StatesTaking people
Westchester Medical CenterValhalla, United StatesTaking people
George Washington University HospitalWashington D.C., United StatesTaking people
MedStar Georgetown University HospitalWashington D.C., United StatesTaking people
MedStar Washington Hospital CenterWashington D.C., United StatesNo longer taking part
Burke Rehabilitation CenterWhite Plains, United StatesTaking people
PIH Health Hospital WhittierWhittier, United StatesTaking people
New Hanover Regional Medical CenterWilmington, United StatesTaking people
Central DuPage HospitalWinfield, United StatesTaking people
Forsyth Medical CenterWinston-Salem, United StatesTaking people
Wake Forest Baptist Medical CenterWinston-Salem, United StatesTaking people
Umass Memorial Medical CenterWorcester, United StatesTaking people
Metro Health HospitalWyoming, United StatesNo longer taking part

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Print a page for my doctor

Trial details

Who runs it: Yale University
Trial code: NCT03907046
Record updated: 8 May 2026
Original description: Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF).Read full original descriptionShow less
Anticoagulation in Intracerebral Hemorrhage (ICH) Survivors for Stroke Prevention and Recovery
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF).
Secondary Aim: To determine if apixaban, compared with aspirin, results in better functional outcomes as measured by the modified Rankin Scale.
Inclusion: Age at least 18 years; Intracerebral hemorrhage (ICH) (including primary intraventricular hemorrhage) confirmed by brain CT or MRI; Can be randomized within 14-180 days after ICH onset; Non-valvular AF (defined as atrial fibrillation or atrial flutter), documented by electrocardiography or a physician-confirmed history of prior AF; Provision of signed and dated informed consent form by patient or legally authorized representative; For females of reproductive potential: use of highly effective contraception.
Exclusion: Previous or planned left atrial appendage closure; Concomitant participation in a competing trial; Index event is hemorrhagic transformation of a brain infarction or hemorrhage into a tumor; History of earlier ICH within 12 months preceding index event; Clear indication for anticoagulant drugs (e.g., requires anticoagulation for deep vein thrombosis or pulmonary embolism) or antiplatelet drugs (e.g., requires aspirin or clopidogrel for recent coronary stent); Clinically significant bleeding diathesis; Active hepatitis or hepatic insufficiency with Child-Pugh score B or C; Known allergy to aspirin or apixaban; Considered by the investigator to have a condition that precludes safe or active participation in the trial; Serum creatinine ≥2.5 mg/dL; Anemia (hemoglobin <8 g/dL) or thrombocytopenia (<100 x 10\^9/L) that is chronic in the judgment of the investigator; Active infective endocarditis; Pregnant or breastfeeding; Persistent, uncontrolled systolic blood pressure (≥180 mm Hg); ICH caused by an arteriovenous malformation (AVM) that has not yet been secured.
ClinicalTrials.gov NCT03907046