Atrial fibrillation trials in United States

In United States 146 Also abroad 724

146 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable
Where
Amarillo, Anderson, Atlanta, Bloomfield Hills, Brownsville, Concord, Dallas, Dothan, Farmington Hills, Flint, Fremont, Glendale, Houston, Huntington Beach, Indianapolis, Jackson, Jacksonville, Johns Creek, La Jolla, Little Rock, Lufkin, Marion, McKinney, Medley, Merrillville, Missouri City, Munster, Northridge, Olive Branch, Pasadena, Pensacola, Rapid City, Santa Maria, Sarasota, Staten Island, Tullahoma, Ventura, Vienna, West Hills, West Monroe, Winter Park
Age
18 years and over
People
2,628 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07430956 · EU 2025-521618-25-00
No phaseTaking people
Intracardiac Echocardiography Guided Watchman Device Implant
Where
Cleveland
Age
18 years and over
People
100
Run by
The Cleveland Clinic
See details and how to joinNCT06007872
No phaseNot yet taking people in United States
Evaluation of the Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal Atrial Fibrillation
Where
Bellevue, Jonesboro
Age
18 years and over
People
250
Run by
Kardium Inc.
See details and how to joinNCT07714876
Phase 2Taking people
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
Where
Amarillo, Atlanta, Boston, Clinton, Covina, Cutler Bay, Dothan, Encinitas, Fairhope, Farmington Hills, Flint, Fremont, Ft. Washington, Greensboro, Huntington Beach, Indianapolis, Jefferson City, Johns Creek, Maplewood, Marion, Maumee, McKinney, Medley, Merrillville, Miami Lakes, Missouri City, Odessa, Pasadena, Pomona, Rapid City, Redding, Richmond, Santa Rosa, Sarasota, Tyler, Ventura, West Hills, West Monroe, Winter Park
Age
18 years and over
People
1,200 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07175428
No phaseNot yet taking people in United States
Hummingbird ICE Study
Where
Camden, Detroit
Age
18 years and over
People
1,000
Run by
Philips Clinical & Medical Affairs Global
See details and how to joinNCT07552272
Phase 3Taking people
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation
Where
Alexander City, Amarillo, Atlanta, Bloomfield Hills, Boca Raton, Brownsville, Clinton, Concord, Covina, Cutler Bay, Dothan, Fairhope, Fargo, Farmington Hills, Flint, Foxborough, Fremont, Ft. Washington, Glendale, High Point, Hobart, Houston, Huntington Beach, Inglewood, Inverness, Johns Creek, La Jolla, Little Rock, Manassas, Marion, Maumee, Medley, Missouri City, Munster, Newport Beach, New Smyrna Beach, Northridge, Odessa, Pasadena, Pensacola, Rapid City, Saint Augustine, Santa Maria, Sarasota, Scottsdale, Staten Island, Tullahoma, Tyler, Ventura, Vienna, West Hills, West Monroe, Winter Park
Age
18 years and over
People
15,364 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07626411 · EU 2025-521617-97-00
No phaseTaking people
A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System
Where
Aurora, Austin, Cincinnati, Detroit, Fort Worth, Fountain Valley, Iowa City, Jacksonville, Janesville, Kansas City, Lake Success, Miami, Naperville, Orlando, Overland Park, Phoenix, Plano, Rochester, Springfield, The Bronx, Trenton, Tucson, Ventura, Winchester, Ypsilanti
Age
22 years and over
People
276
Run by
Biosense Webster, Inc.
See details and how to joinNCT07227532
Phase 3Taking people
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
Where
Albuquerque, Atlanta, Aurora, Austin, Baltimore, Boston, Buffalo, Burlington, Chapel Hill, Charleston, Charlottesville, Chicago, Cincinnati, Clearwater, Columbia, Columbus, Dallas, Detroit, Duluth, Elk Grove Village, Evanston, Flemington, Gainesville, Grand Rapids, Hackensack, Houston, Indianapolis, Iowa City, Jacksonville, Kansas City, Littleton, Los Angeles, Madison, Miami, Milwaukee, Minneapolis, Naperville, New York, Oklahoma City, Paoli, Philadelphia, Phoenix, Piscataway, Pittsburgh, Providence, Queens, Richmond, Ridgewood, Royal Oak, Sacramento, Salt Lake City, San Diego, San Francisco, Sarasota, Scarborough, Stanford, Staten Island, St Louis, Stony Brook, Stuart, Tacoma, Valhalla, Warner Robins, Washington D.C., White Plains, Winston-Salem, Winter Haven, Wooster, Worcester, Wyomissing, Ypsilanti
Age
22 years to 85 years
People
5,350
Run by
Johns Hopkins University
See details and how to joinNCT05836987
No phaseTaking people
A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation
Where
Atlanta, Austin, Boston, Fountain Valley, Jacksonville, Jonesboro, Lexington, Miami, Murray, Naples, New Brunswick, New York, Plano, Raleigh, Rochester, Savannah, The Bronx, Ventura, Ypsilanti
Age
18 years to 80 years
People
566
Run by
Biosense Webster, Inc.
See details and how to joinNCT07523750
No phaseTaking people
A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation
Where
Atlantis, Aurora, Birmingham, Edgewood, Hartford, Janesville, Jonesboro, Oklahoma City, Philadelphia, Santa Monica, The Bronx, Traverse City, Tucson
Age
18 years to 80 years
People
1,070
Run by
Biosense Webster, Inc.
See details and how to joinNCT07527299
No phaseTaking people
Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
Where
Bethesda
Age
18 years to 110 years
People
135
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT05724121
No phaseTaking people
PULSED AF Post-Approval Study
Where
Anderson, Atlanta, Charleston, Charlottesville, Chicago, Cincinnati, Columbus, Dallas, Doylestown, Durham, Fall River, Grove City, New York, Omaha, Royal Oak, Tampa, Wenatchee, Whitesburg
Age
18 years and over
People
580 worldwide
Run by
Medtronic Cardiac Ablation Solutions
See details and how to joinNCT06578104
Phase 2Taking people
A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation
Where
Camden, Durham, Murray, New York, Seattle, Tupelo
Age
18 years and over
People
165 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07217067
No phaseTaking people
BOdygUardian MOnitoriNg for ReCurrencE of AF
Where
Delray Beach, Iowa City, Miami, Pittsburgh, Salt Lake City
Age
18 years and over
People
100
Run by
Heart Rhythm Clinical and Research Solutions, LLC
See details and how to joinNCT07671677
No phaseNot yet taking people in United States
Exclusion of Left Atrial Appendage Thrombus in Emergency Department Patients With Atrial Fibrillation Undergoing CT to Assess for Pulmonary Embolus: A Feasibility Study
Where
Manhasset
Age
18 years and over
People
60
Run by
Northwell Health
See details and how to joinNCT07647939
No phaseTaking people
Globe Registry: Globe® Pulsed Field System Registry Study for Treating Patients With Symptomatic Atrial Fibrillation
Where
Bellevue, Jonesboro
Age
18 years and over
People
500
Run by
Kardium Inc.
See details and how to joinNCT07651852
No phaseEnrolling by invitation
Intracardiac Echocardiography Catheter Supply-Chain Reliability and Clinical Access Study
Where
New York
Age
18 years and over
People
200
Run by
Truway Health, Inc.
See details and how to joinNCT07788040
No phaseTaking people
Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation
Where
Atlanta, Austin, Boston, Charleston, Columbus, Jonesboro, Mechanicsburg, New York, Tyler, West Des Moines
Age
18 years and over
People
571 worldwide
Run by
Boston Scientific Corporation
See details and how to joinNCT07575269
No phaseTaking people
Pericardiotomy in Cardiac Surgery
Where
Houston, Louisville, New York
Age
18 years and over
People
1,400 worldwide
Run by
Population Health Research Institute
See details and how to joinNCT06486636
No phaseTaking people
Repeatable Evaluation of Functional Intra-procedural Signals for Effect in Pulsed Field Ablation REFINE-PFA
Where
Paramus, Ypsilanti
Age
21 years and over
People
40
Run by
CathVision ApS
See details and how to joinNCT07275151
No phaseTaking people
Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.
Where
New Orleans
Age
18 years to 79 years
People
98
Run by
Tulane University School of Medicine
See details and how to joinNCT04703166
Phase 2Taking people
A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation
Where
Aurora, Boston, Detroit, Durham, Fort Worth, Maplewood, San Francisco, Tyler
Age
18 years to 85 years
People
360 worldwide
Run by
Bayer
See details and how to joinNCT07625215 · EU 2025-523807-31-00
No phaseTaking people
Comparison of Two Pulse Field Ablation Systems for AF Ablation
Where
Pittsburgh
Age
18 years to 89 years
People
120
Run by
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
See details and how to joinNCT07883629
No phaseTaking people
Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
Where
Atlanta, Birmingham, Boston, Cleveland, Columbus, Dallas, Falls Church, Fort Worth, Kansas City, La Jolla, Los Angeles, Lynchburg, Naples, Nashville, New Hyde Park, Newport News, New York, Orlando, Philadelphia, Pittsburgh, Savannah, The Bronx
Age
18 years and over
People
400 worldwide
Run by
Medtronic Cardiac Ablation Solutions
See details and how to joinNCT07298473
No phaseTaking people
Elite AF IDE Trial (Elite AF)
Where
Charlotte, Jonesboro
Age
18 years and over
People
400
Run by
Boston Scientific Corporation
See details and how to joinNCT07287436