Studies gut bacteria in Crohn's disease with and without spondyloarthritis
Compares gut microbes in adults with Crohn's disease, spondyloarthritis, or both.
Plain-language title generated from the registry record
Registry title: Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.
Key facts
- Where
- Nancy and Paris, FranceSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with Crohn's disease, axial spondyloarthritis, or both. It compares their gut bacteria and blood markers with healthy controls.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Crohn's disease diagnosed at least 3 months ago, axial spondyloarthritis, or both. Patients with only one of the two must not have the other disease.
- Earlier treatment
- No antibiotics or bowel preparation for colonoscopy in the 8 weeks before the stool sample.
Main reasons for not taking part
- Past removal of part of the colon
- Antibiotics or colon preparation in the 8 weeks before stool collection
- Ostomy at the time of sampling
- BMI above 30
- Extreme diet, unbalanced diabetes, or pregnancy
Read by machine on 12 November 2026.
Where in France
- Central HospitalNancy, FranceContact: Laurent MD PEYRIN-BIROULET, PhDTaking people
- Saint-Antoine HospitalParis, FranceContact: Harry SOKOL, MD, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Central Hospital, Nancy, France
- Trial code
- NCT03983473
- Record updated
- 18 June 2026
- Original description
The MICROSPA project aims to compare gut microbiota, serum cytokines, and PBMC of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA). 3 groups of patients will be analyzed: patients suffering from CD alone, patients suffering from SpA alone, patients suffering from CD and SpA. One group of healthy controls will be analysed as a comparator. Fecal microbiota will be determined by bacteriome, virome and fungome NGS sequencingRead full original descriptionShow less
Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease. Identification de Biomarqueurs de SPondylArthrite Chez Les Patients Atteints de Maladie de CROhn présents Dans le MICrobiote fécal.
The MICROSPA project aims to compare gut microbiota, serum cytokines, and PBMC of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA). 3 groups of patients will be analyzed: patients suffering from CD alone, patients suffering from SpA alone, patients suffering from CD and SpA. One group of healthy controls will be analysed as a comparator. Fecal microbiota will be determined by bacteriome, virome and fungome NGS sequencing
Inclusion: Age ≥ 18 years; Patients will be recruited according to 3 groups:; Patients with Crohn's disease and axial spondyloarthritis according to the criteria below; Patients with Crohn's disease (MC patients) with a diagnosis established according to clinical, biological criteria, radiological, endoscopic and / or histological studies for 3 months. With diagnosis of exclusion of a spondyloarthritis on criteria ASAS and / or New York modified; Patients with axial spondyloarthritis (SpA patients) with a diagnosis based on modified ASAS and / or New York criteria with exclusion diagnosis of Crohn's disease; Patient with the ability to give free and express informed consent.
Exclusion: Taking antibiotics or colon preparation for colonoscopy within 8 weeks before stool collection (Temporary contraindication = removal possible before colic or first bowel preparation after the start of colonic preparation); History of colonic resection; unbalanced diabetes; Ostomy at the time of sampling; BMI> 30; extreme diet; Pregnant woman; Patient under guardianship, under curatorship or under the protection of justice Contacts/Locations Central Contact.