Taking people in United StatesNo phase
Low muscle mass and chemotherapy side effects in older adults with colorectal cancer
Looks at low muscle mass and chemotherapy side effects in older adults with colorectal cancer.
Plain-language title generated from the registry record
Registry title: Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
Key facts
- Where
- Ankeny, Ann Arbor, Ashland, Baton Rouge, Bemidji, Bismarck, Bloomington, Boiling Springs, Brainerd, Brighton, Canton, Cape Girardeau, Carroll, Carterville, Cedar Rapids, Charlotte, Chelsea, Chicago, Chillicothe, Clemmons, Clive, Columbus, Concord, Coon Rapids, Danville, Decatur, Deer River, Des Moines, Detroit Lakes, Duluth, Easley, Eau Claire, Edina, Effingham, Fargo, Farmington, Findlay, Flint, Fort Dodge, Gaffney, Galesburg, Gastonia, Green Bay, Greenville, Greenwood, Greer, Hazleton, Hibbing, Houma, Iron Mountain, Lewisburg, Lewistown, Lexington, Livonia, Maplewood, Marshfield, Mattoon, Millville, Minneapolis, Minocqua, Mount Vernon, New Ulm, Newark, Normal, O'Fallon, Ottawa, Park Rapids, Pekin, Peoria, Peru, Pontiac, Portsmouth, Pottsville, Reed City, Rehoboth Beach, Rice Lake, Rolla, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, Sandstone, Scranton, Selinsgrove, Seneca, Shakopee, Sioux Falls, Spartanburg, Spooner, Springfield, St Louis, State College, Stevens Point, Sturgeon Bay, Sullivan, Sunset Hills, Union, Urbana, Virginia, Washington, Washington D.C., Weston, Wilkes-Barre, Wilkesboro, Willmar, Wilmington, Winston-Salem, Wyoming, Ypsilanti, and Zanesville, United StatesSee the 147 sites
Where in United States
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, United StatesTaking people
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, United StatesTaking people
- Duluth Clinic AshlandAshland, United StatesTaking people
- Louisiana Hematology Oncology Associates LLCBaton Rouge, United StatesTaking people
- Mary Bird Perkins Cancer CenterBaton Rouge, United StatesTaking people
- MBP Cancer Center - Baton Rouge GeneralBaton Rouge, United StatesTaking people
- Sanford Joe Lueken Cancer CenterBemidji, United StatesTaking people
- Sanford Bismarck Medical CenterBismarck, United StatesTaking people
- Illinois CancerCare-BloomingtonBloomington, United StatesTaking people
- Prisma Health Cancer Institute - SpartanburgBoiling Springs, United StatesTaking people
- Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
- Trinity Health Medical Center - BrightonBrighton, United StatesTaking people
- Illinois CancerCare-CantonCanton, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
- Trinity Health Medical Center - CantonCanton, United StatesTaking people
- Saint Francis Medical CenterCape Girardeau, United StatesTaking people
- Saint Anthony Regional HospitalCarroll, United StatesTaking people
- SIH Cancer InstituteCarterville, United StatesTaking people
- Oncology Associates at Mercy Medical CenterCedar Rapids, United StatesTaking people
- Physicians' Clinic of Iowa PCCedar Rapids, United StatesTaking people
- Atrium Health Pineville/LCI-PinevilleCharlotte, United StatesTaking people
- Atrium Health University City/LCI-UniversityCharlotte, United StatesTaking people
- Carolinas Medical Center/Levine Cancer InstituteCharlotte, United StatesTaking people
- Levine Cancer Institute-SouthParkCharlotte, United StatesTaking people
- Chelsea HospitalChelsea, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
- John H Stroger Jr Hospital of Cook CountyChicago, United StatesTaking people
- Adena Regional Medical CenterChillicothe, United StatesNo longer taking part
- Wake Forest University at ClemmonsClemmons, United StatesTaking people
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesTaking people
- John B Amos Cancer CenterColumbus, United StatesTaking people
- The Mark H Zangmeister CenterColumbus, United StatesNo longer taking part
- Atrium Health Cabarrus/LCI-ConcordConcord, United StatesTaking people
- Mercy HospitalCoon Rapids, United StatesTaking people
- Minnesota Oncology - Coon RapidsCoon Rapids, United StatesNo longer taking part
- Carle at The RiverfrontDanville, United StatesTaking people
- Geisinger Medical CenterDanville, United StatesTaking people
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
- Essentia Health - Deer River ClinicDeer River, United StatesTaking people
- Broadlawns Medical CenterDes Moines, United StatesTaking people
- Iowa Methodist Medical CenterDes Moines, United StatesTaking people
- Mercy Medical Center - Des MoinesDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesTaking people
- Essentia Health Saint Mary's - Detroit Lakes ClinicDetroit Lakes, United StatesTaking people
- Essentia Health Cancer CenterDuluth, United StatesTaking people
- Prisma Health Cancer Institute - EasleyEasley, United StatesTaking people
- Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesTaking people
- Fairview Southdale HospitalEdina, United StatesTaking people
- Crossroads Cancer CenterEffingham, United StatesTaking people
- Essentia Health Cancer Center-South University ClinicFargo, United StatesTaking people
- Sanford Broadway Medical CenterFargo, United StatesTaking people
- Sanford Roger Maris Cancer CenterFargo, United StatesTaking people
- Parkland Health Center - FarmingtonFarmington, United StatesTaking people
- Armes Family Cancer CenterFindlay, United StatesNo longer taking part
- Cancer Hematology Centers - FlintFlint, United StatesTaking people
- Genesee Hematology Oncology PCFlint, United StatesTaking people
- Genesys Hurley Cancer InstituteFlint, United StatesTaking people
- UI Healthcare Mission Cancer and Blood - Fort DodgeFort Dodge, United StatesTaking people
- Gibbs Cancer Center-GaffneyGaffney, United StatesTaking people
- Illinois CancerCare-GalesburgGalesburg, United StatesTaking people
- Levine Cancer Institute-GastonGastonia, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, United StatesTaking people
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, United StatesTaking people
- Prisma Health Cancer Institute - ButternutGreenville, United StatesTaking people
- Prisma Health Cancer Institute - EastsideGreenville, United StatesTaking people
- Prisma Health Cancer Institute - FarisGreenville, United StatesTaking people
- Self Regional HealthcareGreenwood, United StatesNo longer taking part
- Gibbs Cancer Center-PelhamGreer, United StatesTaking people
- Prisma Health Cancer Institute - GreerGreer, United StatesTaking people
- Geisinger Medical Center-Cancer Center HazletonHazleton, United StatesTaking people
- Essentia Health Hibbing ClinicHibbing, United StatesTaking people
- Terrebonne General Medical CenterHouma, United StatesTaking people
- Marshfield Medical Center DickinsonIron Mountain, United StatesTaking people
- Geisinger Medical Oncology-LewisburgLewisburg, United StatesTaking people
- Lewistown HospitalLewistown, United StatesTaking people
- Saint Joseph Hospital EastLexington, United StatesNo longer taking part
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, United StatesTaking people
- Saint John's Hospital - HealtheastMaplewood, United StatesTaking people
- Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesTaking people
- Beebe South Coastal Health CampusMillville, United StatesTaking people
- Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
- Health Partners IncMinneapolis, United StatesNo longer taking part
- Marshfield Medical Center - MinocquaMinocqua, United StatesTaking people
- SSM Health Good SamaritanMount Vernon, United StatesTaking people
- Knox Community HospitalMount Vernon, United StatesNo longer taking part
- New Ulm Medical CenterNew Ulm, United StatesTaking people
- Helen F Graham Cancer CenterNewark, United StatesTaking people
- Medical Oncology Hematology Consultants PANewark, United StatesTaking people
- Licking Memorial HospitalNewark, United StatesNo longer taking part
- Carle BroMenn Medical CenterNormal, United StatesTaking people
- Carle Cancer Institute NormalNormal, United StatesTaking people
- Cancer Care Center of O'FallonO'Fallon, United StatesTaking people
- Illinois CancerCare-Ottawa ClinicOttawa, United StatesTaking people
- Essentia Health - Park RapidsPark Rapids, United StatesTaking people
- Illinois CancerCare-PekinPekin, United StatesTaking people
- Illinois CancerCare-PeoriaPeoria, United StatesTaking people
- Illinois CancerCare-PeruPeru, United StatesTaking people
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesTaking people
- Southern Ohio Medical CenterPortsmouth, United StatesNo longer taking part
- Geisinger Cancer Services-PottsvillePottsville, United StatesTaking people
- Corewell Health Reed City HospitalReed City, United StatesTaking people
- Beebe Health CampusRehoboth Beach, United StatesTaking people
- Marshfield Medical Center-Rice LakeRice Lake, United StatesTaking people
- Mercy Clinic-Rolla-Cancer and HematologyRolla, United StatesNo longer taking part
- Heartland Regional Medical CenterSaint Joseph, United StatesTaking people
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
- Regions HospitalSaint Paul, United StatesTaking people
- United HospitalSaint Paul, United StatesTaking people
- Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesTaking people
- Essentia Health SandstoneSandstone, United StatesTaking people
- Community Medical CenterScranton, United StatesTaking people
- Geisinger Medical Oncology-SelinsgroveSelinsgrove, United StatesTaking people
- Prisma Health Cancer Institute - SenecaSeneca, United StatesTaking people
- Saint Francis Regional Medical CenterShakopee, United StatesTaking people
- Sanford Cancer Center Oncology ClinicSioux Falls, United StatesTaking people
- Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesTaking people
- Spartanburg Medical CenterSpartanburg, United StatesTaking people
- Essentia Health-Spooner ClinicSpooner, United StatesTaking people
- CoxHealth South HospitalSpringfield, United StatesTaking people
- Mercy Hospital SpringfieldSpringfield, United StatesTaking people
- Southern Illinois University School of MedicineSpringfield, United StatesTaking people
- Springfield ClinicSpringfield, United StatesTaking people
- Springfield Regional Cancer CenterSpringfield, United StatesNo longer taking part
- Missouri Baptist Medical CenterSt Louis, United StatesTaking people
- Geisinger Medical GroupState College, United StatesTaking people
- Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, United StatesTaking people
- Missouri Baptist Sullivan HospitalSullivan, United StatesTaking people
- BJC Outpatient Center at Sunset HillsSunset Hills, United StatesTaking people
- SMC Hematology Oncology-UnionUnion, United StatesTaking people
- Carle Cancer CenterUrbana, United StatesTaking people
- Essentia Health Virginia ClinicVirginia, United StatesTaking people
- Illinois CancerCare - WashingtonWashington, United StatesTaking people
- MedStar Georgetown University HospitalWashington D.C., United StatesTaking people
- Marshfield Medical Center - WestonWeston, United StatesTaking people
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, United StatesTaking people
- Wake Forest Baptist Health - Wilkes Medical CenterWilkesboro, United StatesTaking people
- Rice Memorial HospitalWillmar, United StatesTaking people
- Christiana Care Health System-Wilmington HospitalWilmington, United StatesTaking people
- Wake Forest University Health SciencesWinston-Salem, United StatesTaking people
- University of Michigan Health - WestWyoming, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology -Ann ArborYpsilanti, United StatesTaking people
- Genesis Healthcare System Cancer Care CenterZanesville, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Wake Forest University Health Sciences
- Trial code
- NCT03998202
- Record updated
- 5 November 2026
- Original description
This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.Read full original descriptionShow less
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer: The M&M Study
This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.
Inclusion: Newly diagnosed metastatic CRC or newly recognized metastatic recurrence of CRC >= to 3 months (12 weeks) from completion of treatment of non-metastatic CRC; Planning to or recently started to undergo undergo immunotherapy and/or 5-FU based chemotherapy as a first line of treatment. 5-FU chemotherapy can be 5-FU alone or in combination with oxaliplatin and/or irinotecan +/- immunotherapy. Capecitabine is also acceptable. If unable to engage patient before treatment starts, enrollment is allowed up to four weeks after the start of treatment but must be before Cycle 2 begins; Estimated life expectancy >= 6 months; Patients must be able to comprehend English or Spanish (for questionnaire completion); Ability to understand and the willingness to sign a written informed consent document; Patient eligibility is not dependent on BMI or weight. Patients with a significant (+- > 10%) body weight change in the previous 12 months are eligible for this study.
Exclusion: Prior systemic chemotherapy for metastatic colorectal cancer (ok if adjuvant chemotherapy completed >= 3 months (12 weeks) prior to this disease disease recurrence and treatment); Patients may not be receiving any other investigational agents. (For clarity, participants on the Alliance A021703 trial are also eligible for this study); Patients on or planned to undergo radiation therapy in near future; Patients enrolled on hospice; No untreated brain metastases. Patients with treated brain metastases are eligible.