Colorectal cancer trials in United States

In United States 556 Also abroad 1929

556 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Where
Boston, Grand Rapids, Houston, Los Angeles, Nashville, New Haven, Newton, Trumbull
Age
18 years and over
People
430 worldwide
Run by
Pfizer
See details and how to joinNCT04557449 · EU 2024-512120-11-00
No phaseTaking people
Role of Diet on the Microbiome of the Digestive System
Where
Houston
Age
45 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04666727
Phase 1/2Taking people
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Where
Ann Arbor, Baltimore, Boston, Charlottesville, Fairfax, Houston, Los Angeles, Nashville, New York, Philadelphia, Salt Lake City, Seattle, St Louis
Age
18 years and over
People
616 worldwide
Run by
Verastem, Inc.
See details and how to joinNCT07020221
No phaseEnrolling by invitation
Natural History Study of Early Life Exposures in Agriculture (ELEA)
Where
Bethesda
Age
18 years to 99 years
People
64,277
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07328516
Phase 1Taking people
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Where
Austin, Celebration, Denver, Detroit, Duarte, East Brunswick, Fairfax, Fort Worth, Houston, Irvine, Irving, Lake Success, Nashville, New Haven, New York, Plantation, San Antonio, Sarasota, Spokane, West Valley City
Age
18 years and over
People
150 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07503808 · EU 2026-526299-21-00
Phase 1Not yet taking people in United States
Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy
Where
Bethesda
Age
18 years to 120 years
People
20
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07715903
No phaseNot yet taking people in United States
Symptomatic FIT for Colon Cancer Detection, a Pilot Study
Where
La Jolla
Age
18 years and over
People
40
Run by
University of California, San Diego
See details and how to joinNCT07927270
No phaseNot yet taking people in United States
SCREEN Yourself for Cancer
Where
Hershey
Age
30 years to 75 years
People
852
Run by
Milton S. Hershey Medical Center
See details and how to joinNCT07927686
No phaseTaking people
Evaluation for NCI Surgery Branch Clinical Research Protocols
Where
Bethesda
Age
18 years and over
People
7,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00001823
No phaseTaking people
Collection of Blood From Patients With Cancer
Where
Bethesda
Age
18 years and over
People
1,750
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00034216
No phaseTaking people
Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies
Where
Bethesda
Age
18 years and over
People
750
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00451022
Phase 2Taking people
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer
Where
Bethesda
Age
18 years to 72 years
People
332
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01174121
No phaseTaking people
Genomic Services Research Program
Where
Bethesda
Age
1 month to 105 years
People
5,000
Run by
National Human Genome Research Institute (NHGRI)
See details and how to joinNCT02595957
Phase 1Taking people
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Where
Bethesda, Fairway
Age
12 years to 120 years
People
116
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04222413
Phase 1Taking people
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Where
Bethesda
Age
18 years to 120 years
People
60
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04847063
Phase 1Taking people
Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer
Where
Aurora, Charlottesville, Columbus, Costa Mesa, Fairway, Houston, Irvine, Kansas City, Los Angeles, New Orleans, Oklahoma City, Orange, Overland Park, Richmond, Westwood
Age
18 years and over
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06102902
Phase 1/2Taking people
Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)
Where
Bethesda
Age
18 years to 120 years
People
60
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06149481
Phase 1Taking people
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Where
Arlington Heights, Aurora, Baton Rouge, Birmingham, Boston, Denton, Detroit, Duarte, Durham, Encinitas, Jacksonville, Kingwood, Lone Tree, Los Angeles, Nashville, New Haven, New Hyde Park, Newport Beach, New York, Norwich, Phoenix, Pittsburgh, Port Jefferson Station, Rochester, Salem, Seattle, Spokane, Stanford, Tampa, The Bronx, Webster
Age
18 years and over
People
542 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT04929223 · EU 2023-505163-37-00
Phase 2Taking people
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Where
Grand Forks, Jacksonville
Age
18 years and over
People
220
Run by
Mayo Clinic
See details and how to joinNCT05969860
Phase 2Not yet taking people in United States
SAMe in Prevention of Oxaliplatin-associated Liver Injury
Where
Los Angeles
Age
18 years and over
People
30
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT06258525
Phase 2Taking people
Tislelizumab in People With Colorectal Cancer
Where
New York
Age
18 years and over
People
40 worldwide
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06529523
Phase 1Taking people
A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors
Where
Atlanta, Aurora, Boston, Fairfax, Houston, New York, Santa Rosa, Sarasota, Tampa, Tyler
Age
18 years to 99 years
People
600 worldwide
Run by
Erasca, Inc.
See details and how to joinNCT06983743 · EU 2026-525794-39-00
No phaseTaking people
The Vanguard Study: Testing a New Way to Screen for Cancer
Where
Bethesda, Brownstown, Chapel Hill, Charlottesville, Chesterfield, Cheyenne Wells, Cleveland, Clinton Township, Dearborn, Denver, Detroit, Durham, Fairfax, Fort Collins, Greeley, Grosse Pointe Farms, Honolulu, Kansas City, Lafayette, Livonia, Lone Tree, Loveland, Milwaukee, Minneapolis, Norfolk, Novi, Oklahoma City, Pleasanton, Plymouth, Portsmouth, Richmond, Royal Oak, San Diego, South Hill, Springfield, Sterling Heights, St Louis, Tacoma, Troy, West Bloomfield, Wyandotte
Age
45 years to 75 years
People
24,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06995898
Phase 3Taking people
Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
Where
Aberdeen, ‘Aiea, Aitkin, Allentown, Alma, Alpena, Alton, Anaconda, Anchorage, Ankeny, Ann Arbor, Appleton, Arroyo Grande, Asheboro, Ashland, Augusta, Baker City, Ballwin, Bardstown, Battle Creek, Baxter, Belfast, Bellingham, Bend, Bethlehem, Billings, Bloomington, Boiling Springs, Boise, Bolivar, Bonita Springs, Bozeman, Brainerd, Branson, Braselton, Brighton, Brunswick, Burbank, Burlington, Burnsville, Caldwell, Canton, Cape Girardeau, Carbondale, Carmichael, Carroll, Carterville, Carthage, Cedar Rapids, Centralia, Chadds Ford, Charleston, Chelsea, Cheyenne, Cincinnati, Clackamas, Clarkston, Clive, Cody, Coeur d'Alene, Colorado Springs, Coon Rapids, Coos Bay, Corbin, Creston, Crosslake, Damariscotta, Danville, Decatur, Deer River, Des Moines, Detroit, Detroit Lakes, Dixon, Duluth, Durango, Easley, East China, East Stroudsburg, Edina, Edmonds, Effingham, Elk Grove, Elkton, Ely, Escanaba, Eureka, Everett, ‘Ewa Beach, Fargo, Farmington, Flint, Fort Dodge, Fort Lauderdale, Fort Myers, Fort Smith, Fosston, Fruitland, Gaffney, Gainesville, Galesburg, Garden City, Georgetown, Gladwin, Grand Island, Grand Rapids, Great Bend, Great Falls, Green Bay, Greensboro, Greenville, Greenwood, Greer, Grosse Pointe Woods, Havre, Hayward, Hazleton, Helena, Hendersonville, Hibbing, Honolulu, Hood River, International Falls, Issaquah, Jamestown, Joplin, Kalamazoo, Kalispell, Kearney, Kennewick, Kewanee, Lacey, Lakewood, Lansing, Lewes, Lexington, Little Rock, Livonia, London, Longmont, Longview, Lynchburg, Macomb, Maple Grove, Maplewood, Martinsville, Mattoon, Merced, Meridian, Midland, Millville, Minneapolis, Missoula, Monroe, Monticello, Moose Lake, Mount Pleasant, Mount Sterling, Mount Vernon, Muskegon, Nampa, Napa, Neenah, Newark, Newberg, New London, New Richmond, New Ulm, New York, Niles, Normal, Norton Shores, Oconto Falls, O'Fallon, Oklahoma City, Omaha, Ontario, Oregon City, Osage Beach, Oshkosh, Ottawa, Park Rapids, Pekin, Pella, Peoria, Pequot Lakes, Peru, Phoenix, Pine River, Pittsburg, Pontiac, Portland, Post Falls, Princeton, Pueblo, Redmond, Reed City, Rehoboth Beach, Reidsville, Richmond, Roanoke, Robbinsdale, Rocklin, Rockport, Rolla, Sacramento, Saginaw, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Sandpoint, Sandstone, Sanford, San Luis Obispo, Santa Maria, Santa Rosa, Savannah, Seattle, Sedro-Woolley, Seneca, Shakopee, Shawano, Sheboygan, Shreveport, Silverdale, South Hill, South Portland, Spartanburg, Spokane, Spooner, Springfield, Staples, Stillwater, St Louis, Stockton, Sturgeon Bay, Sullivan, Sunset Hills, Superior, Tawas City, Traverse City, Twin Falls, Union, Urbana, Vancouver, Virginia, Waconia, Walla Walla, Warren, Washington, Waukee, Waupaca, West Des Moines, Westminster, Willmar, Wilmington, Woodbury, Woodland, Wyoming, Ypsilanti
Age
18 years and over
People
1,057 worldwide
Run by
SWOG Cancer Research Network
See details and how to joinNCT07018869
No phaseTaking people
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
Where
Ankeny, Ann Arbor, Ashland, Baton Rouge, Bemidji, Bismarck, Bloomington, Boiling Springs, Brainerd, Brighton, Canton, Cape Girardeau, Carroll, Carterville, Cedar Rapids, Charlotte, Chelsea, Chicago, Chillicothe, Clemmons, Clive, Columbus, Concord, Coon Rapids, Danville, Decatur, Deer River, Des Moines, Detroit Lakes, Duluth, Easley, Eau Claire, Edina, Effingham, Fargo, Farmington, Findlay, Flint, Fort Dodge, Gaffney, Galesburg, Gastonia, Green Bay, Greenville, Greenwood, Greer, Hazleton, Hibbing, Houma, Iron Mountain, Lewisburg, Lewistown, Lexington, Livonia, Maplewood, Marshfield, Mattoon, Millville, Minneapolis, Minocqua, Mount Vernon, Newark, New Ulm, Normal, O'Fallon, Ottawa, Park Rapids, Pekin, Peoria, Peru, Pontiac, Portsmouth, Pottsville, Reed City, Rehoboth Beach, Rice Lake, Rolla, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Sandstone, Scranton, Selinsgrove, Seneca, Shakopee, Sioux Falls, Spartanburg, Spooner, Springfield, State College, Stevens Point, St Louis, Sturgeon Bay, Sullivan, Sunset Hills, Union, Urbana, Virginia, Washington, Washington D.C., Weston, Wilkes-Barre, Wilkesboro, Willmar, Wilmington, Winston-Salem, Wyoming, Ypsilanti, Zanesville
Age
60 years and over
People
300
Run by
Wake Forest University Health Sciences
See details and how to joinNCT03998202