Studying Inherited Diabetes Risk and Blood Sugar Response in Non-Diabetic People
Compares blood sugar handling in people with high or low inherited diabetes risk.
Plain-language title generated from the registry record
Registry title: Phenotyping Genetic Risk for Type 2 Diabetes
Key facts
- Where
- Philadelphia, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 70 years old?
Source: NCT04024631, who can take part
Where in United States
- Childrens Hospital of PhiladelphiaPhiladelphia, United StatesNot yet recruiting
- University of PennsylvaniaPhiladelphia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Pennsylvania
- Trial code
- NCT04024631
- Record updated
- 21 September 2026
- Original description
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.Read full original descriptionShow less
Phenotyping Children and Adults With Possible High or Low Genetic Risk for Type 2 Diabetes
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Inclusion: Age 10-70 years; Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research; Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher.
Exclusion: prior diagnosis of type 1, type 2, or secondary diabetes; recent systemic chemotherapy use; hypothalamic obesity or related genetic disorder of metabolism; gastrointestinal impairment or surgery that may impact absorption; major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult; use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication; acute illness that may impact insulin and glucose dynamics; pregnancy; anemia; inability to comply with study protocol.