The Impact of Oxidative Stress on Erythrocyte Biology
Reason given: Funding not renewed
Key facts
- Where
- Chapel Hill, United StatesSee the site
- Phase
- Phase 2
Where in United States
- University of North Carolina at Chapel HillChapel Hill, United StatesNo longer taking part
Trial details
- Who runs it
- University of North Carolina, Chapel Hill
- Trial code
- NCT04028700
- Record updated
- 3 June 2025
- Original description
This study will address if red blood cells transfused to a sickle cell patient from a donor with a glucose-6-phosphate-dehydrogenase (G6PD) enzyme deficiency have a different lifespan as measured by the percentage of red blood cells that survive post-transfusion compared to red blood cells transfused to a sickle cell patient from a donor without a G6PD enzyme deficiency.Read full original descriptionShow less
Red Blood Cell Survival Study: The Impact of Oxidative Stress on Erythrocyte Biology
This study will address if red blood cells transfused to a sickle cell patient from a donor with a glucose-6-phosphate-dehydrogenase (G6PD) enzyme deficiency have a different lifespan as measured by the percentage of red blood cells that survive post-transfusion compared to red blood cells transfused to a sickle cell patient from a donor without a G6PD enzyme deficiency.
Inclusion: Age 18-60 years; Has diagnosis of sickle cell disease; Steady state (no pain or baseline pain and ≥1 month from any hospital admission); Receiving chronic transfusions (i.e., regular transfusion every 4-8 weeks).
Exclusion: History of transfusion reactions not adequately managed by antihistamines; HIV positive; At investigator discretion for uncontrolled inter-current illness or social situation limiting compliance with study requirements; Does not have crossmatch compatible red cells; Known G6PD deficiency; Hepato- or splenomegaly; Participation in another therapeutic trial; Pregnant or nursing; Inability to speak and/or read English.